6223 Results for: "Comparator+Kits&pageNo=31&view=list"

Supplier: Bioss

MSK1 is a mitogen and stress activated protein kinase 1 which belongs to the AGC family of kinases and is related in structure to the ribosomal p70 S6 kinase subfamily. MSK1 can be activated by ERK1/2 and SAPK2/p38 MAP kinase. It is also known to be required for the phosphorylation of CREB, ATF1 H3 and HMG14 in response to mitogen and stress. Similar to RSK, MSK1 contains two kinase domains (N term and a C term). Once phosphorylated on Thr581 and Ser360 by ERK1/2 and SAPK2/p38, MSK1 autophosphorylate on at least 5 sites. Of these autophosphorylation sites Ser212 and Ser376 get phosphorylated by the C terminal kinase domain of MSK1 which is essential for the catalytic activity of the N terminal kinase domain. MSK2 plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.

Supplier: Bioss

MSK1 is a mitogen and stress activated protein kinase 1 which belongs to the AGC family of kinases and is related in structure to the ribosomal p70 S6 kinase subfamily. MSK1 can be activated by ERK1/2 and SAPK2/p38 MAP kinase. It is also known to be required for the phosphorylation of CREB, ATF1 H3 and HMG14 in response to mitogen and stress. Similar to RSK, MSK1 contains two kinase domains (N term and a C term). Once phosphorylated on Thr581 and Ser360 by ERK1/2 and SAPK2/p38, MSK1 autophosphorylate on at least 5 sites. Of these autophosphorylation sites Ser212 and Ser376 get phosphorylated by the C terminal kinase domain of MSK1 which is essential for the catalytic activity of the N terminal kinase domain. MSK2 plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.

Supplier: VARIAN

LOWER RACK 12 PL. - 50ML COLL. TUBES 1 * 1 items

Supplier: Hettich

The HettCube range of cooled incubators provide functionality and customised features. The inner chamber is made from acid-proof stainless steel (DIN 1.4301). Units only heat and cool as necessary, ensuring lower power consumption, operating costs and environmental impact. At an operating temperature of 37 °C the units consume less than 0,05 kWh. The fan is located outside the usable space, so there is a low air flow inside the chamber and a low noise level.

Supplier: HAMILTON BONADUZ

The 1000 series is a mid volume Gastight® syringe. Gastight® syringes are ideal for dispensing both liquids and gases. They have a precision machined PTFE plunger tip which creates a leak-free seal. With the tight fit, the tip essentially wipes the interior of the syringe barrel free of sample. This feature is particularly useful with heterogeneous samples as it reduces the chance that a deposit will occur and cause the plunger to freeze.

Supplier: LAUDA

CONNECTOR BOARD 31POLE FLANGE PRI 1 * 1 items

Supplier: MEMMERT

Usb-ethernet adapter for sfplus 1 * 1 items

Supplier: MEMMERT

Usb-ethernet adapter for inplus 1 * 1 items

Supplier: MEMMERT

Usb-ethernet adapter for snplus 1 * 1 items

Supplier: MEMMERT

Usb-ethernet adapter for unplus 1 * 1 items

Supplier: MEMMERT

Usb-ethernet adapter for ifplus 1 * 1 items

Supplier: MEMMERT

Usb-ethernet adapter for inplus 1 * 1 items

Supplier: MEMMERT

Usb-ethernet adapter for ifplus 1 * 1 items

Supplier: MEMMERT

Usb-ethernet adapter for sfplus 1 * 1 items

Supplier: MEMMERT

Usb-ethernet adapter for snplus 1 * 1 items

Supplier: MEMMERT

Usb-ethernet adapter for unplus 1 * 1 items

Supplier: MEMMERT

Usb-ethernet adapter for unplus 1 * 1 items

Supplier: MEMMERT

Usb-ethernet adapter for ifplus 1 * 1 items

Supplier: MEMMERT

Usb-ethernet adapter for ifplus 1 * 1 items

Supplier: MEMMERT

Usb-ethernet adapter for ifplus 1 * 1 items

Supplier: MEMMERT

Usb-ethernet adapter for inplus 1 * 1 items

Supplier: MEMMERT

Usb-ethernet adapter for ufplus 1 * 1 items

Supplier: MEMMERT

Usb-ethernet adapter for ufplus 1 * 1 items

Supplier: MEMMERT

Usb-ethernet adapter for ufplus 1 * 1 items

Supplier: MEMMERT

Usb-ethernet adapter for sfplus 1 * 1 items

Supplier: MEMMERT

Usb-ethernet adapter for snplus 1 * 1 items

Supplier: MEMMERT

Usb-ethernet adapter for sfplus 1 * 1 items

Supplier: MEMMERT

Usb-ethernet adapter for inplus 1 * 1 items

Supplier: MEMMERT

Usb-ethernet adapter for sfplus 1 * 1 items

Supplier: MEMMERT

Usb-ethernet adapter for sfplus 1 * 1 items