6217 Results for: "Comparator+Kits&pageNo=31&view=list"

Supplier: Bioss

The KCTD11 gene encodes a protein that has been identified as a suppressor of Hedgehog Signalling. Its inactivation might lead to a deregulation of the tumour promoting Hedgehog pathway in medulloblastoma. Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumour repressor and inhibits cell growth and tumourigenicity of medulloblastoma (MDB). Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state.

Supplier: Bioss

E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.

Supplier: Bioss

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism.

Supplier: Bioss

Nck is a highly conserved, oncogenic protein. It is a common target for the action of different surface receptors, encoding one SH2 and three SH3 domains, the Src homology motifs found in nonreceptor tyrosine kinases, Ras GTPase activating protein, phosphatidylinositol 3 kinase, and phospholipase Cg. Nck is widely expressed in various tissues and in cell lines from human, murine, and rat origins. Nck is phosphorylated on tyrosine, serine, and threonine residues in response to stimulation of EGF and PDGF in A431 and NIH 3T3 cells respectively. Like other SH2 containing proteins, Nck is associated with tyrosine autophosphorylated EGF or PDGF receptors via its SH2 domain. Overexpression of Nck leads to transformation of NIH 3T3 cells.

Supplier: JULABO GmbH

The MAGIO™ series of heating circulators operate with a working temperature range of 20 to +300 °C and heating capacity of up to 3 kW. With their powerful pressure/suction pump the MAGIO™ units are ideal for external temperature applications. An extensive range of accessories and excellent dynamics mean that the MAGIO™ circulators can be modularly and individually adapted to applications.

Supplier: Bioss

Ubiquitin is an abundant, highly conserved protein found in all eukaryotic cells either free or covalently attached to cellular proteins. The primary function of ubiquitin in mammalian systems is to clear abnormal, foreign, and improperly folded proteins by targeting them for proteosome degradation. UBE2D proteins, including UBE2D1 (ubiquitin-conjugating enzyme E2D1 or UBC5A), UBE2D2 (ubiquitin-conjugating enzyme E2D2 or UBC5B) and UBE2D3 (ubiquitin-conjugating enzyme E2D3 or UBC5C), are E2 ubiquitin-conjugating enzymes that catalyze the ubiquitination of I˚Bå in a phosphorylation and SCFB-TRCP-dependent manner. Specifically, E1 first transfers a ubiquitin residue to the E2 component (a UBE2D protein), and the UBE2D protein then associates with an E3 ubiquitin-protein ligase, which immediately transfers that residue to a protein that is targeted for degradation.

Supplier: Bioss

14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic Signalling and cell-cycle checkpoints. Seven isoforms comprise this family of Signalling intermediates, denoted 14-3-3 b, g, e, z, h, q and s. 14-3-3 proteins form dimers that present two binding sites for ligand proteins, thereby bringing together two proteins that may not otherwise associate. These ligands largely share a 14-3-3 consensus binding motif and exhibit serine/threonine phosphorylation. 14-3-3 proteins function in broad regulation of these ligand proteins; by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation, activation/repression of enzymatic activity, and facilitation of protein modification. Loss of expression contributes to a vast array of pathogenic cellular activities.

Supplier: Bioss

The Ca²⁺/calmodulin-dependent protein kinases (CaMKs) comprise a structurally related subfamily of serine/threonine kinases. CaMKI Beta (Ca²⁺/calmodulin-dependent protein kinase type 1B), also known as PNCK (pregnancy up-regulated non-ubiquitously expressed CaM kinase) or BSTK3, is a 343 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one protein kinase domain. Existing as multiple alternatively spliced isoforms, CaMKI Beta functions to catalyse the ATP-dependent phosphorylation of CaMKI, an event that activates CaMKI activity and may be important for Ca²⁺-triggered Signalling cascades within the cell. The gene encoding CaMKI Beta maps to human chromosome X, which contains nearly 153 million base pairs and houses over 1000 genes.

Supplier: Bioss

Aurora related kinase-1 (ARK-1) is a centrosome-associated serine/threonine kinase that regulates centrosome separation, bipolar spindle assembly and chromosome segregation during mitosis. Bora (protein aurora borealis) is a 559 amino acid protein that activates ARK-1. Bora is localised to the nucleus until mitosis is initiated, when it then translocates to the cytoplasm. This translocation is dependent on activated Cdc2, which releases Bora to bind and activate ARK-1 in the cytoplasm. Plk (polo-like kinase) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation on its N-terminus by ARK-1. It is through this mechanism that Bora and ARK-1 control cellular mitotic entry. Downregulation of the gene encoding Bora results in multipolar spindles in mitosis, a phenomenon that is also observed when ARK-1 function is blocked.

Supplier: Bioss

Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. PCDH17 is a 1159 amino acid single-pass type I membrane protein that contains six cadherin domains. Expressed as multiple alternatively spliced isoforms, PCDH17 is thought to function as a calcium-dependent cell adhesion protein that may play a role in establishing cell-cell connections within brain tissue. The gene encoding PCDH17 maps to human chromosome 13, which houses over 400 genes, such as BRCA2 and RB1, and comprises nearly 4% of the human genome.

Supplier: HELLMA

Hellma® high precision quartz glass macro cells for fluorescence measurements in the UV/Vis range, 10 mm and 10×10 mm path length, with transition nozzle from Quartz/Duran.

Supplier: S.C.A.T.

The SCAT SafetyCaps provide maximum safety for your HPLC solvent supply. Extract your solvents safely from bottles and reservoirs without being exposed to hazardous gases and solvent vapours. Complete with integrated air valve for pressure equalisation.

Supplier: SCHOTT AG Lighting and imaging

The SCHOTT EasyLED portfolio for stereo microscopy delivers precise LED light for a wide variety of applications, such as laboratory and diagnostics, industrial applications, education, or forensic science. The series offers robust design and easy handling in a compact device, with a range of accessories for specific requirements.

Supplier: Avantor Fluid Handling

Monitor transfer of delicate biological fluids with EtherNet/IP™ control capability.

Supplier: VWR Collection

These trousers are manufactured from 99% polyester fibres and 1% Hydro-Tec fibres. The special fabric, with Hydro-Tec nanotechnology finish, makes the trousers extremly durable and provides anti-static features as well as protection against dirt, oil, chemicals and water.

Supplier: Thermo Fisher Scientific

Suitable for even the most demanding and sensitive applications, the family of Thermo Scientific™ Barnstead™ GenPure™ water purification systems deliver ultrapure 18,2 MΩ.cm water with consistent quality.

Supplier: Whatman products (Cytiva)

Whatman non-sterile mixed cellulose ester (MCE) filters from Cytiva are suitable for E. coli culturing, enumeration of bacteria, and other culturing and cell counting methods.

Supplier: FRISTADS KANSAS

Short trousers made of 65% polyester and 35% cotton, with soft nap on reverse side.

Supplier: FRISTADS KANSAS

Gilets made from 65% polyester and 35% cotton; napped inner.

Supplier: FRISTADS KANSAS

Overalls made from 65% polyester, 35% cotton, with soft nap on reverse side.

Supplier: ERGOMAT

The Ergomat Softline is made from nitrile rubber and is designed to increase comfort while reducing tripping hazards, body aches, quality issues, and sick leaves. It is designed for areas where resistance to oil, petrochemicals and heat is important. Ideal for wet environments, in case of excessive volumes of fluids, the Softline can be die-cut to allow for drainage.

Supplier: FRISTADS KANSAS

Tubular knit T-shirts made from 100% ring-spun cotton (single jersey). The grey melange shirt is made from 85% cotton and 15% viscose, while the yellow version is made from 65% polyester and 35% cotton.

Supplier: Corning

Corning® Nu-Serum™ IV is a growth medium supplement that provides a low-protein alternative to newborn calf, fetal bovine, and other sera routinely used for cell culture.

Supplier: Sartorius

These filter papers are used for routine analyses like clarification, determination of substances, but also as discs with a center hole for technical applications. Grades with a wet burst resistance >30 kPa are referred to as wet-strengthened and are therefore
suitable for pressure or vacuum filtration.

Supplier: Corning

The robust organoid counting software package is designed to meet the unique needs of customers as 3D populations are known to vary in
morphologies dependent on numerous environmental factors or protocols.

Supplier: EUTECH

This water- and dust-proof tester is ideal for quick and accurate pH checks in pools and spas, aquariums and hydroponics operations, cooling towers, food processing water and process/wastewater. The double junction electrode makes the tester ideal for dirty water and solutions with heavy metals or contaminants, while increased reference gel volume offers significantly longer electrode life. Also suitable for educational purposes in schools.

Supplier: EUTECH

This waterproof tester is designed with advanced microprocessor technology to give you up to ±2 mV of accuracy across a wide measuring range. User-replaceable double-junction sensor with a wide platinum band provides highly accurate results even in wet and rugged environments. Ideal for measurements in electroplating rinse tanks, swimming pools, drinking water, waste water, chemical processing, cyanide destruction and chromate reduction.

Supplier: ANTIBODIES.COM

Human C1orf31 ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human C1orf31 in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: Thermo Fisher Scientific

ClipTip™ pipette tips provide security with a unique and innovative interlocking technology that ensures a complete seal on every channel with minimal tip attachment and ejection force.

Supplier: FRISTADS KANSAS

Double-face sweatshirt made from 80% cotton and 20% polyester. Doubleface means that the outside of the fabric looks the same as the inside. The fabric is slightly stronger with an exclusive finish and long-lasting fit.