145746 Results for: "Chromatography+Software&pageNo=10&view=easy"

Supplier: BANDELIN-ELECTRONIC

SONOREX SUPER RK 1040, ULTRASONIC BATH, 35 KHZ, 230 V 50/60 HZ, ID DIA. 540 MM, 500 MM HIGH, 38 L, S/S TIMER 1-15 MIN AND CONTINU OUS, DRAIN BALL COCK 1/2 , ULTRASONIC PEAK OUTPUT 1200 W, HF-OUTPUT: 300 WEFF. 1 * 1 items

Supplier: BANDELIN-ELECTRONIC

SONOREX SUPER RK 255 H, ULTRASONIC BATH, 35 KHZ, 230 V~ 50/60 HZ, ID 300X150X150 MM 5,5 L, S/S TIMER 1-15 MIN AND CONTINUOUS, HEA TING 30-80°C (86-176°F), DRAIN BALL COCK 1/4 , ULTRASONIC PEAK OUTPUT 640 W, HF-OUTPUT: 160 WEFF. 1 * 1 items

Supplier: BANDELIN-ELECTRONIC

SONOREX SUPER RK 510 H, ULTRASONIC BATH, 35 KHZ, 230 V~ 50/60 HZ, ID 300X240X150 MM 9,7 L, S/S TIMER 1-15 MIN AND CONTINUOUS, HEA TING 30-80°C (86-176°F), DRAIN BALL COCK 1/2 , ULTRASONIC PEAK OUTPUT 640 W, HF-OUTPUT: 160 WEFF. 1 * 1 items

Supplier: TECHNI GLOVE

Nitrile GL30cmTechniGlove TN1204Wtacky 1 * 1.000 items

Supplier: Quantabio

Ultra-Plex™ 1-Step ToughMix® is a ready-to-use, 4X-concentrated master mix for reverse transcription quantitative PCR (RT-qPCR) of RNA templates using hybridisation probe detection chemistries such as TaqMan® 5’-hydrolysis probes on Real-Time PCR systems that utilise ROX passive reference with 490 nM excitation. First-strand cDNA synthesis and PCR amplification are carried out in the same tube without opening between procedures. It is ideal for highly sensitive quantification of RNA viruses or low abundance RNA targets in uni- or multiplexed RT-qPCR applications as well as high throughput gene-expression studies. The system has been optimised to deliver maximum RT-qPCR efficiency, sensitivity, and specificity in reduced reaction volumes and fast cycle times. Ultra-Plex™ 1-Step ToughMix® contains all required components for RT-qPCR except RNA template and probe. It is compatible with all dual-labeled probe chemistries.

Supplier: Bioss

Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. GRB14 is a potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.

Supplier: Bioss

Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. GRB14 is a potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.

Supplier: MACHEREY-NAGEL

TLC precoated plates CEL 300-25 size: 10x20 cm pack of 50 1 * 50 items

Supplier: OMEGA BIO-TEK

Plasmid isolated with traditional purification procedures normally contain high levels of endotoxins that can significantly interfere with transfection experiments downstream. The E.Z.N.A.® Endo-Free Plasmid kits integrate an efficient endotoxin removal step into the plasmid purification procedure to produce high quality transfection grade plasmid.

Supplier: MEMMERT

This steriliser complies with all relevant standards and regulations for medical products and guarantees reliable programme sequences, irrespective of the load and chamber volume. Especially due to the SetpointWAIT function the validation of this hot air steriliser is possible anytime. The SetpointWAIT function ensures that the programme is only continued when the setpoint temperature has been reached. Precisely maintaining the sterilisation time and thus completely killing off even highly resistant microorganisms is therefore guaranteed at all times, irrespective of the sterilisation load and chamber volume. This feature can also be used with additional, freely positionable Pt100 temperature sensors. In this case, sterilisation only begins when the setpoint temperature has been reached at all measurement points – that is, in the load. For the special application of depyrogenisation, the hot-air steriliser is absolutely ideal. The SF models are equipped with single display.

Supplier: ProSci Inc.

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.

Supplier: ProSci Inc.

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.

Supplier: Portwest

This jacket offers exceptional weather protection, comfort, and warmth while utilising the latest innovations in recycled fabrics. The outer shell, lining, and wadding are certified recycled polyester, and the packaging is derived from sugarcane, allowing the wearer to champion sustainability without compromising on performance.

Supplier: Portwest

These multi use high visible bodywarmer vests are specially designed for those who will not compromise on style, comfort, protection and performance. These garments are designed to keep warm, dry and visible in all conditions. The 300D Oxford Industry High Visibility provides comprehensive range of single and combination garments in a highly durable and cleverly designed innovative styles.

Supplier: EPPENDORF

This centrifuge features a superior capacity of up to 4×1000 ml which makes it the ideal instrument for high-throughput and large volume applications. It has a powerful refrigeration system with advanced temperature management to keep samples safe.

Supplier: BANDELIN-ELECTRONIC

SONOREX LONGLIFE RK 1050 CH, ULTRASONIC BATH, 35 KHZ, 230 V~ 50/60 HZ, ID 600X500X300 MM 90 L, OSCILLATING TANK OF 2 MM S/S AISI 3 16 TI TIMER 1-15 MIN AND CONTINUOUS, HEATING 30-80°C (86-176°F), DRAIN BALL COCK 1/2 , ULTRASONIC PEAK OUTPUT 2400 1 * 1 items

Supplier: Amarell

Hydrometer, DIN 12791/similar to BS 718, L20, 0,9000-0,9200:0,0002g/cm , ref. temp. 20C, without therm., 430mm long, suitable for g overnment verification 1 * 1 items

Supplier: ProSci Inc.

The transcription factor Forkhead-box A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha, is a member of the FOX class of transcription factors. HNF-1 (alpha and beta), HNF-3 (alpha, beta and gamma), HNF-4 (alpha and gamma), and HNF-6 compose, in part, a homeoprotein family designated the hepatocyte nuclear factor family. The various HNF-1 isoforms regulate transcription of genes in the liver as well as in other tissues such as kidney, small intestine and thymus. FOXA1 is expressed in normal breast ductal epithelium and other epithelium in different organs, such as lung, pancreas, bladder, prostate, and colon. Recently, FOXA1 has been shown to be a major determinant of estrogen-ER activity and endocrine response in breast cancer cells. FOXA1 expression correlates with estrogen receptor (ER)-positivity, especially in luminal subtype A breast cancers, which is associated with favorable prognosis. FOXA1 is useful in the sub-classification of breast carcinomas.

Supplier: ProSci Inc.

The transcription factor Forkhead-box A1, also known as hepatocyte nuclear factor 3-alpha, is a member of the FOX class of transcription factors. HNF-1 (alpha and beta), HNF-3 (alpha, beta and gamma), HNF-4 (alpha and gamma), and HNF-6 compose, in part, a homeoprotein family designated the hepatocyte nuclear factor family. The various HNF-1 isoforms regulate transcription of genes in the liver as well as in other tissues such as kidney, small intestine and thymus. FOXA1 is expressed in normal breast ductal epithelium and other epithelium in different organs, such as lung, pancreas, bladder, prostate, and colon. Recently, FOXA1 has been shown to be a major determinant of estrogen-ER activity and endocrine response in breast cancer cells. Its expression correlates with estrogen receptor (ER)-positivity, especially in luminal subtype A breast cancers, which is associated with favorable prognosis. FOXA1 is useful in the sub-classification of breast carcinomas.

Supplier: ProSci Inc.

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene; all three variants encode the same protein.

Supplier: SCOTSMAN

ACM ice cubers:
The ACM series self contained ice cube makers are air cooled, electronically controlled and manufactured from 304 stainless steel. They produce standard medium thimble shaped super cubes that are very hard and crystal clear. Thimble shaped cubes have a large surface area so that they melt slower than a standard cube and makes them better for chilling. It also means that they are less likely to stick together in the integral storage bin or in an ice bucket. The ice cubers require a 19 mm (0,75") ‘washing machine' type tapped mains water supply, a correctly rated power supply and a 38 mm (1,5") vented drain (ideally no higher than the base of the machine) within one metre of the machines intended position before delivery.
With integral ice cube storage bin.

Supplier: Ahlstrom-Munksjö

Ahlstrom AutoCollect™ specimen collection cards for high-throughput environments work efficiently in both DBS punch and direct elution. They are designed for microvolume sampling, transport and storage of dried blood spot (DBS) at ambient temperature.

Supplier: ProSci Inc.

EphrinB proteins are thought to play key roles in cellular functions as diverse as neuronal migration and blood vessel development (Flanagan and Vancerhaeghen, 1998; Dufour et al., 2003; Oike et al., 2002). EphrinB molecules expressed at the membrane surface bind to the EphB family receptors on target cells during cellto cell contact. This interaction leads to cell signaling in the target cell but also generates a reverse signal in the cell expressing EphrinB on its surface. This reverse signaling event is thought to be critical for vessel maturation and neuronal development. Importantly, tyrosine phosphorylation of EphrinB is thought to be a critical component of this reverse signaling event (Palmer et al., 2002). Recent work suggests that phosphorylation of a specific EphrinB residue (Tyr298) plays a key role in EphrinB signaling (Kalo, et al., 2001).

Supplier: ProSci Inc.

PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids). Recombinant murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two B chains (218 total amino acids).

Supplier: Portwest

The anti-static Modaflame multi norm arc softshell jacket is constructed from a highly protective three-layer softshell fabric. Using modacrylic and carbon fibre elements, the softshell provides flame, chemical, anti-static, and high visibility protection. An interactive zipper allows this softshell to be zipped into an outer jacket for additional insulation if required.

Supplier: Portwest

The stylish and functional rain jacket will ensure you stand out from the crowd. Made from 300D Oxford PU coated durable stain resistant fabric, this jacket features the new Insulatex heat reflective lining panel, which reflects heat back into the body ensuring maximum warmth and comfort.

Supplier: Thermo Fisher Scientific

Thermo Scientific Pierce Sulfo-SMCC, No-Weigh Format is a water-soluble, amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length cyclohexane spacer arm (8.3 angstroms).

Supplier: ENVIROFALK PHARMAWATERSYSTEMS

FILTER ACTIVE CARBON 20'' ELEMENT 10UM 1 * 1 items

Supplier: Testo

FILTER 325 1 * 1 items

Supplier: Honeywell Safety

SLEEVES HYPALON 1 * 1 items