12763 Results for: "CPC+COLDER&pageNo=48"

Supplier: Bioss

Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilisation and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells.

Supplier: Avantor Fluid Handling

Masterflex L/S Drive with Easy-Load II High-Performance Pump Head, 100 rpm - Delivered with Masterflex Power Cord, 230 VAC, European Plug Type-F 180 cm long 1 * 1 items

Supplier: Avantor Fluid Handling

Masterflex L/S Drive with Easy-Load II High-Performance Pump Head, 100 rpm - Delivered with Masterflex Power Cord, 230 VAC, British Plug Type-G 180 cm long 1 * 1 items

Supplier: Abnova

Mouse monoclonal antibody raised against partial recombinant rat Kcnk3. 1 * 100 µG

Supplier: Abnova

Mouse monoclonal antibody raised against partial recombinant rat Kcnk3. 1 * 100 µG

Supplier: Abnova

Mouse monoclonal antibody raised against partial recombinant rat Kcnk3. 1 * 100 µG

Supplier: Abnova

Mouse monoclonal antibody raised against partial recombinant rat Kcnk3. 1 * 100 µG

Supplier: Abnova

Mouse MAB raised against partial recombinant rat Kcnk3. 1 * 100 µG

Supplier: Abnova

Mouse monoclonal antibody raised against partial recombinant rat Kcnk3. 1 * 100 µG

Supplier: ERLAB CAPTAIRE

PREFILTER PARTICULATE FOR CAPTAIR 483 1 * 1 items

Supplier: Abnova

Mouse MAB raised against partial recombinant rat Kcnk3. 1 * 100 µG

Supplier: Abnova

Mouse monoclonal antibody raised against partial recombinant rat Kcnk3. 1 * 100 µG

Supplier: Abnova

Mouse monoclonal antibody raised against partial recombinant rat Kcnk3. 1 * 100 µG

Supplier: GRAVIS

BOTTLE 250ML ROUND W/PP BLACK CAP 48MM 1 * 42 items

Supplier: Abnova

Mouse monoclonal antibody raised against partial recombinant rat Kcnk3. 1 * 100 µG

Supplier: Rockland Immunochemicals

Protein Tat, Transactivating regulatory protein, Human immunodeficiency virus type 1 (HIV-1), control peptide, blocking peptide 1 * 1 mg

Supplier: UVEX

SHOE 6571.7 O2 FO SRC W10 SIZE48 1 * 1 PAIR

Supplier: Cole Parmer

Melting point apparatus, complete with IQOQ documentation and pack of 100 melting point tubes, open at one end. 1 * 1 items

Supplier: UVEX

SHOE 6571.8 O2 FO SRC W11 SIZE48 1 * 1 PAIR

Supplier: UVEX

SHOE 65708 O1 FO SRC W11 SIZE48 1 * 1 PAIR

Supplier: Avantor Fluid Handling

FTNG PLG 1/8 PVDF 1 * 1 items

Supplier: Avantor Fluid Handling

1/2 X 3/4 PT TBNG 1 * 25 items

Supplier: Biosensis

BDNF belongs to the neurotrophin family and regulates the survival and differentiation of neurons during development. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. Microglia release BDNF that may contribute to neuroinflammation and neuropathic pain.FUNCTION: Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. SUBCELLULAR LOCATION: Secreted protein. POst translation modification: Converted into mature BDNF by plasmin (PLG). SIMILARITY: Belongs to the NGF-beta family.

Supplier: OMEGA BIO-TEK

E.Z.N.A.® Fastfilter® Plasmid kits rapidly purify plasmid DNA utilising lysate clearance filter syringes, whilst E-Z 96® Fastfilter Plasmid kits employ lysate clearance plates in a 96-well format. Fastfilter® kits allow midi- and maxi-scale plasmid isolation in less than 40 m.

Supplier: Avantor Fluid Handling

Repair kit for EZB11D1-PE 1 * 1 items

Supplier: UVEX

SHOE 65707 O1 FO SRC W10 SIZE48 1 * 1 PAIR

Supplier: UVEX

SHOE 6571.9 O2 FO SRC W12 SIZE48 1 * 1 PAIR

Supplier: US Biological

Interleukin 4 Induced Protein 1, Recombinant, Human (IL­4I1, FIG­1, L-amino acid oxidase) 1 * 20 µG

Supplier: BROTHER

PAPER, WHITE, LENGTH 30,48 M (BANDWIDTH 50 MM) 1 * 1 Roll

Supplier: GILSON

Inlet Tubing Assembly,3.2X4.8X2500 mm,Fep,H3 1 * 1 items