145766 Results for: "Bismuth+vanadium+tetraoxide&pageNo=10&view=list"

Supplier: Thermo Fisher Scientific

Pierce silver stain for mass spectrometry is a complete kit for rapid and ultra-sensitive silver staining of proteins in polyacrylamide gels and efficient destaining of excised gel pieces for mass spectrometry analysis. This kit enables both first-time and experienced users to achieve consistent and reliable staining using high, low, and gradient-percentage gels in 1D and 2D formats. The optimised staining method ensures extremely sensitive staining while minimizsing covalent crosslinking of protein to the gel matrix, which can inhibit protein recovery. The destaining reagents facilitate complete removal of silver from stained protein bands and maximum protein recovery for subsequent mass spectrometry analysis.

Supplier: VACUUBRAND

The VacuuCenter BVC professional serves for aspiration and disposal of biological fluids, providing outstanding levels of comfort and safety for working with biological and biohazardous materials. A non contact sensor monitors the liquid level in the collection bottle electronically and prevents overfilling. A disinfection routine allows the suction of disinfectants through an aspiration hand set and tubing after switching off the pump, and so supports demanding safety protocols. The BVC professional with 4 litre PP bottle that has self-closing quick couplings minimises risk in transporting hazardous waste and of contamination in the workplace. The version with coated 2 litre borosilicate glass bottle allows the user to work with aggressive disinfectants like chlorine bleach.

Supplier: Thermo Fisher Scientific

Thermo Scientific Pierce TCEP-HCl is a potent, versatile, odorless, thiol-free reducing agent with broad application to protein and other research involving reduction of disulfide bonds. The unique compound is easily soluble and very stable in many aqueous solutions. TCEP reduces disulfide bonds as effectively as dithiothreitol (DTT), but unlike DTT and other thiol-containing reducing agents, TCEP does not have to be removed before certain sulfhydryl-reactive crosslinking reactions.

Supplier: VISION ENGINEERING

The Makrolite 4K digital microscope simplifies your visual inspection, image capture and measurement tasks with the exceptional quality of Ultra High Definition image resolution.

Supplier: ProSci Inc.

Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins. Eight members of HDAC family have been identified in the past several years. These HDAC family members are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8, each of which contains a deacetylase domain exhibiting from 45 to 93% identity in amino acid sequence. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about twofold larger than those of the class I members, and the deacetylase domains are present within the C-terminal regions, except that HDAC-6 contains two copies of the domain, one within each of the N-terminal and C-terminal regions. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns. These results suggested that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo.

Supplier: ProSci Inc.

ACTH (or Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This mAb is specific to CLIP (aa 25-39) and does not react with Synacthen (aa 1-24). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.

Supplier: Biosensis

The capsaicin receptor (VR1, TRPV1) is a ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. The receptor seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. It is involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca2+-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH less than 6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis (Ref: uniprot.org).

Supplier: BANDELIN-ELECTRONIC

titanium probe TS 106, titanium probe, dia. 6 mm, for HD 4050/4100/4200 1 * 1 items

Supplier: VITLAB

Volumetric flask, PMP, class B, with stopper NS 12/21, PP, 50 mL 1 * 2 items

Supplier: HAAKE

VISCOTESTER IQ PACK FOR PASTES TM-PE-P 1 * 1 SET

Supplier: HIRSCHMANN

VOL.FLASK 20ML NS10/19 AMBER POLYSTOPP A 1 * 1 items

Supplier: USA SCIENTIFIC PLASTICS

Tip pipette 10µl hinged rack certified sterile 1 * 960 items

Supplier: MERCK PRODUCTION CHEMICALS

L-Arginine hydrochloride 98.5-101.0% (by perchloric acid titration), EMPROVE® EXPERT Ph. Eur., BP, JP, USP suitable for use as excipient, SAFC®

Supplier: TOSOH BIOSCIENCE

TSKgel® SW size exclusion columns are widely used for aqueous analysis and isolation of proteins, antibodies, enzymes, nucleic acids and other biological macromolecules.

Supplier: Mettler - Toledo

These instruments with two or three channels are modularly expandable with additional measurement parameters at any time.

Supplier: ProSci Inc.

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA-Receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha and beta subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha subunits of the receptor. Lastly, phosphorylation of beta subunits of the receptor has been shown to modulate GABAA-R function.

Supplier: ProSci Inc.

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA-Receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha and beta subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha subunits of the receptor. Lastly, phosphorylation of beta subunits of the receptor has been shown to modulate GABAA-R function.

Supplier: GRANT INSTRUMENTS

A range of eco-friendly, refrigerated/heating circulating baths with an intuitive user-interface and sleek design. Units offer significant running cost savings whilst delivering powerful cooling when needed. Choice of 2 models with temperature range of –25 to +150 °C (model dependent*). Ideal for applications in pharmaceutical, education, industrial and life science areas for use with mini pilot plant reactors, cooling rotary evaporators, replacing running tap water cooling, immersing small samples, photometry, chromatography systems, sample preparation, general cooling, reaction chemistry, temperature control, semi-conductor manufacturing, rheometry, refractometry and electrophoresis cooling.

Supplier: OMEGA BIO-TEK

The MicroElute RNA clean-up kit is designed to purify and concentrate RNA (from 50 μg down to picogram amounts) from enzymatic reactions or for desalting RNA samples (e.g. following phenol extraction and ethanol precipitation). The procedure uses lower elution volumes, making it well suited for applications require highly concentrated RNA sample.

Supplier: Sartorius Balances

The Cubis® II laboratory balances are modular, therefore they allow to choose between applications and configurations which suit the best to the needs. These balances can be configured at the level of display, draftshields, software applications and hardware functions.

Supplier: LGC Standards PROMOCHEM

ESTRIOL IMP. F (EP):16-EPI-ESTRIOL 1 * 100 mg

Supplier: BD Medical

Syringe 10ml 20Gx1 inch Luer-Lok 1 * 400 items

Supplier: witeg Labortechnik

WHM12019,Aℓ-case Heating Mantles with Controller, 450℃, for 10,000ml Spherical flask(DU) 1 * 1 items

Supplier: DWK Life Sciences

Valve discharge for DURAN Group dispenser PRO 2,5/5/10ml (PFA/Borosilicate glass/Platin-Iridium) 1 * 1 items

Supplier: VITLAB

Volumetric flask, PP, class B, with screw cap, PP, 100 mL 1 * 2 items

Supplier: Testo

The testo 868s thermal imager, which makes work quicker and easier without foregoing professional thermal imaging technology. Generates error-free and objectively comparable infrared images using its handy functions. The IFOV warner, testo ɛ-Assist and testo ScaleAssist mean you can avoid measurement errors and not only effortlessly achieve optimum setting of emissivity (ɛ) and reflected temperature (RTC) for building thermography, but also of colour scale. This characterised by its professional measuring performance and its easy handling. It has the best thermal image quality in its class, an integrated digital camera and impressive smart functions. The case supplied with the thermal imager means it can be conveniently transported.

Supplier: bimos

Apart from special hygiene features, a laboratory chair must always be ready for use at changing places of work. It should take up a minimum of space yet still offer maximum ergonomics and seating comfort so as to guarantee precise and concentrated work over longer periods of time. Labster is ideal for everyday use in the laboratory.

Supplier: MP Biomedicals

Storage: Store at -20 °C.
Brefeldin A is a fungal metabolite which is a macrocyclic lactone exhibiting a wide range of antibiotic activity. Produced by Penicillium brefeldianum. Blocks binding of the cytosolic coat protein b-COP and ARF to Golgi membranes mediated by protein G. Also blocks protein transportation into post-Golgi compartments. It activates the sphingomyelin cycle. Brefeldin A mediated apoptosis has been observed in human tumor cells.
Brefeldin A reversibly inhibits the intracellular translocation of proteins in eukaryotes, e.g., during transport of proteins to the cell surface for secretion or expression. It has been reported to block the response of cultured cells to cholera toxin. In HepG2 cells, BFA induces two blocks in the secretory pathway; one at the level of the endoplasmic reticulum-Golgi juncture and the other in the trans-Golgi network. Brefeldin A is used in the studies of Brefeldin A-inhibited Guanine Nucleotide-exchange Protein, BIG2, Regulates the Constitutive Release of TNFR1 Exosome-like Vesicles.
Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.

Supplier: ProSci Inc.

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pöltl et al., 2003).

Supplier: Greiner Bio-One

PIPET 5ML SER. PLAS/PLAS TRIPLE PACKING 1 * 100 items