Supplier: Biotium

This MAb reacts with an N-terminal epitope (aa 16-25) of both wild type and mutated p53. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. In most transformed and tumor cells the concentration of p53 is increased 51000 fold over the minute concentrations (1000 molecules cell) in normal cells, principally due to the increased half-life (4 h) compared to that of the wild-type (20 min). p53 Localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution. Mutations arise with an average frequency of 70% but incidence varies from zero in carcinoid lung tumors to 97% in primary melanomas. High concentrations of p53 protein are transiently expressed in human epidermis and superficial dermal fibroblasts following mild ultraviolet irradiation. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia.

Supplier: Thermo Fisher Scientific

Dibromo(1,5-cyclooctadiene)palladium(II) (28,4% Pd)

Supplier: Abcam

Rabbit polyclonal to b4Gal-T6.

Supplier: Abcam

Mouse monoclonal [10] to SRPP.

Supplier: Abcam

Rabbit monoclonal [EP5828(2)] to Galactosidase alpha.

Supplier: Abcam

Rabbit monoclonal [EPR10043(2)] to Orai2 - C-terminal.

Supplier: Abcam

Rabbit monoclonal [EPR11226] to HLA-DPB1.

Supplier: Apollo Scientific

6,7-Dihydro-1,7-naphthyridin-8(5H)-one 98%

Supplier: Apollo Scientific

2-(1,3,5-Trimethyl-1H-pyrazol-4-yl)ethanol 95%

Supplier: Apollo Scientific

7-Chloro-5-methyl[1,2,4]triazolo[1,5-a]pyrimidine 95%

Supplier: Apollo Scientific

1-(1H-1,2,3-Benzotriazol-1-yl)propan-2-one 95%

Supplier: Apollo Scientific

Ethyl 2-(2-oxo-1,2-dihydroquinoxalin-1-yl)acetate, tech

Supplier: Apollo Scientific

1'-(tert-Butoxycarbonyl)-1,4'-bipiperidine-4-carboxylic acid 97%

Supplier: Apollo Scientific

8-Methyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine 95%

Supplier: Apollo Scientific

5-Iodo-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine 95%

Supplier: Apollo Scientific

4,5-Dichloro-1,2,3-dithiazol-2-ylium chloride, tech

Supplier: Apollo Scientific

6-(2-Chloroacetyl)-2H-1,4-benzoxazin-3(4H)-one 95%

Supplier: Apollo Scientific

6-Bromo-1H-[1,2,3]triazolo[4,5-b]pyridine 98%

Supplier: Apollo Scientific

6-Fluoro-4-methyl-2,3-dihydro-1,4-benzoxazine 98%

Supplier: Apollo Scientific

Methyl 2-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate 98%

Supplier: Apollo Scientific

4-Chloro-3H-[1,2,3]triazolo[4,5-c]pyridine 95%

Supplier: Apollo Scientific

tert-Butyl-2-(2-chloroacetyl)-1,2-diazepane-1-carboxylate 95%

Supplier: Apollo Scientific

7-Methyl-2,4-dihydro-1,4-benzoxazin-3-one 98%

Supplier: Apollo Scientific

1,1-Difluoro-5-azaspiro[2.3]hexane hydrochloride 97%

Supplier: Apollo Scientific

Ethyl-4-bromo-1,5-dimethyl-1H-pyrazole-3-carboxylate

Supplier: Apollo Scientific

tert-Butyl-5-oxo-1,4-diazepane-1-carboxylate 95%

Supplier: Apollo Scientific

3-Acetyl-1-benzyl-4-hydroxy-1,2-dihydroquinolin-2-one, tech

Supplier: Apollo Scientific

3-Acetyl-1-ethyl-4-hydroxy-1,2-dihydroquinolin-2-one 95%

Supplier: Apollo Scientific

Methyl-1-oxo-2-(3-pyridinylmethyl)-1,2-dihydro-4-isoquinolinecarboxylate 95%

Supplier: Apollo Scientific

1,2-Dihydronaphtho[2,1-b]furan-2-carboxylic acid 95%