97383 Results for: "6-Cyclobutoxypyridine-2-carboxylic+acid&pageNo=25"

Supplier: HUPFER METALLWERKE

Stainless Steel, E-polished Stainless steel wire shelf, electropolished, consisting of 35 × 10 × 3.0 mm 1 * 1 items

Supplier: Cytiva

illustra™ Hot Start Mix, Ready-To-Go™ is a pre-formulated and pre-dispensed, freeze-dried PCR reagent mix, including high quality PuReTaq™ DNA polymerase and a hot start activator protein, for increased specificity and reproducibility of PCR amplifications. The Ready-To-Go™ beads are provided in either 0,5 or 0,2 ml tubes that are compatible with most thermal cyclers.

Supplier: ProSci Inc.

ORAI3 Monoclonal Antibody: Antigen stimulation of immune cells triggers Ca++ entry t hrough Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2. Larger molecular weight bands are sometimes seen in SDS-PAGE; these may represent post-translationally modified ORAI 3.

Supplier: Thermo Fisher Scientific

Heratherm™ large capacity incubators were designed to prevent samples drying out. All models have a large, easy to view, vacuum fluorescence display and simple to use touch button operation which is controlled by a microprocessor and automatic over-temperature alarm system to protect samples.

Supplier: Thermo Fisher Scientific

Thermo Scientific Pierce EDC is a carboxyl- and amine-reactive zero-length crosslinker. EDC reacts with a carboxyl group first and forms an amine-reactive O-acylisourea intermediate that quickly reacts with an amino group to form an amide bond with release of an isourea by-product. The intermediate is unstable in aqueous solutions and so two-step conjugation procedures rely on N-hydroxysuccinimide (NHS) for stabilization. Failure to react with an amine will result in hydrolysis of the intermediate, regeneration of the carboxyl, and release of an N-substituted urea. A side reaction is the formation of an N-acylurea, which is usually restricted to carboxyls located in hydrophobic regions of proteins.

Supplier: Brand

Volumetric flask PMP (TPX) clear, 50 ml, NS 12/21, PP-stopper 1 * 2 items

Supplier: ProSci Inc.

SLC25A20 is one of several closely related mitochondrial-membrane carrier proteins that shuttle substrates between cytosol and the intramitochondrial matrix space.It mediates the transport of acylcarnitines into mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway. Mutations in this gene are associated with carnitine-acylcarnitine translocase deficiency, which can cause a variety of pathological conditions such as hypoglycemia, cardiac arrest, hepatomegaly, hepatic dysfunction and muscle weakness, and is usually lethal in new born and infants.This gene product is one of several closely related mitochondrial-membrane carrier proteins that shuttle substrates between cytosol and the intramitochondrial matrix space. This protein mediates the transport of acylcarnitines into mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway. Mutations in this gene are associated with carnitine-acylcarnitine translocase deficiency, which can cause a variety of pathological conditions such as hypoglycemia, cardiac arrest, hepatomegaly, hepatic dysfunction and muscle weakness, and is usually lethal in new born and infants. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Supplier: Cytiva

rProtein A Sepharose™ 4 Fast Flow is a well established antibody affinity medium is designed for the purification of monoclonal and polyclonal antibodies based on Sepharose™ Fast Flow platform. The recombinant protein A is produced in E.coli and engineered for an oriented coupling to giving a matrix with enhanced binding capacity. The epoxy-based coupling ensures low ligand leakage. The specificity of the recombinant protein A for the Fc region of IgG is similar to native protein A and provides excellent purification in one step. The high capacity, low ligand leakage and a well established base matrix makes rProtein A Sepharose™ Fast Flow ideal for purification of monoclonal antibodies at both laboratory and process scale.

Supplier: TIGER-VAC

New generation cleanroom vacuum cleaners available in dry recovery. Designed specifically for the pharmaceutical, semiconductor and microelectronics industry.

Supplier: Sartorius Balances

The Cubis® II laboratory balances are modular, therefore they allow to choose between applications and configurations which suit the best to the needs. These balances can be configured at the level of display, draftshields, software applications and hardware functions.

Supplier: Thermo Fisher Scientific

Pierce silver stain for mass spectrometry is a complete kit for rapid and ultra-sensitive silver staining of proteins in polyacrylamide gels and efficient destaining of excised gel pieces for mass spectrometry analysis. This kit enables both first-time and experienced users to achieve consistent and reliable staining using high, low, and gradient-percentage gels in 1D and 2D formats. The optimised staining method ensures extremely sensitive staining while minimizsing covalent crosslinking of protein to the gel matrix, which can inhibit protein recovery. The destaining reagents facilitate complete removal of silver from stained protein bands and maximum protein recovery for subsequent mass spectrometry analysis.

Supplier: Thermo Fisher Scientific

Thermo Scientific Pierce TCEP-HCl is a potent, versatile, odorless, thiol-free reducing agent with broad application to protein and other research involving reduction of disulfide bonds. The unique compound is easily soluble and very stable in many aqueous solutions. TCEP reduces disulfide bonds as effectively as dithiothreitol (DTT), but unlike DTT and other thiol-containing reducing agents, TCEP does not have to be removed before certain sulfhydryl-reactive crosslinking reactions.

Supplier: GRANT INSTRUMENTS

Grant low temperature circulators provide a source of precision cooling for most low temperature applications.

Supplier: ProSci Inc.

MyD88 Monoclonal Antibody: The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. MyD88 has been identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-κB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor, which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.

Supplier: WATERS

XTERRA IS COLUMN 2.1X20MM 25µM HPLC 1 * 1 items

Supplier: 3M Food Safety

3M™ Clean-Trace™ Surface Protein (Allergen) Test Swab ALLTEC60 is a rapid, simple, and reliable solution to monitor the presence of allergens on surfaces to effectively manage cleaning.

Supplier: ProSci Inc.

Principal Names: SnoN; SNO; SKI-like; Ski-related Oncogene; SnoA; SKIL Official Gene Symbol- SKIL Gen Bank Accession Number- NP_005405 Gene ID- 6498(Human) 20482 (mouse)Gene Map Locus- 3q26 (human) SnoN, an 80 kDa protein, is a member of ski family of nuclear proto-oncogenes involved in regulation of cellular transformation and differentiation. Primarily expressed in two isoforms, SnoN is localized in cytoplasm in normal tissues and non-tumorigenic primary epithelial cells. In cancer tissues or cells, SnoN is exclusively localized in the nucleus. It plays a vital role in inhibition of cell cycle arrest induced by TGF-. Upon morphological differentiation or cell-cycle arrest, SnoN translocates into the nucleus, binds to Smad2, Smad3, and Smad4 on TGF- -responsive promoters and represses their ability to activate expression of TGF- target genes. It has also been found to mediate transcriptional repression of thyroid hormone receptor, Mad and pRb. Increased expression of SnoN has been detected in many human tumor cell lines suggesting a clinical significance.

Supplier: VWR Collection

The housing and tank are constructed from high-quality SUS 304 stainless steel, providing durability and longevity. Equipped with user-friendly interface display which offers intuitive function selection and real-time parameter setting. Units also feature intelligent detection on startup, promptly alerting users to any potential issues via buzzer and alarm. Additionally, they continuously monitor the power supply voltage in real-time to ensure optimal operating conditions. The automatic heating stirring function ensures uniform liquid temperature throughout the tank. The anti-leakage tray prevents damage to electrical components and avoids the risk of hazard in case of leakage.

Supplier: Stirling Ultracold

Ultra-low temperature freezer featuring the free-piston Stirling engine. This next generation of environmentally sustainable ULT freezers achieve stable storage conditions over a wide temperature range. The freezer uses 70 to 75% less energy than standard compressor-based ULT freezers, with the industry's best ultra-low cooling performance.

Supplier: SARSTEDT

CONTAINER CATHETER PRODUCTS WITH COVER 1 * 1 items

Supplier: Brand

PP. Eight connected 0,2 or 0,15 ml PCR tubes with attached, flat individual caps.

Supplier: PRECISION DYNAMICS TIMEM

LABELLING TAPE CHARTR.25MMX12,7M 1 * 1 Roll

Supplier: ProSci Inc.

DDX25 is a member of DEAD box proteins family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis,spermatogenesis, and cellular growth and division. DDX25 is a gonadotropin-regulated and developmentally expressed testicular RNA helicase. It may serve to maintain testicular functions related to steroidogenesis and spermatogenesis.DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The encoded protein is a gonadotropin-regulated and developmentally expressed testicular RNA helicase. It may serve to maintain testicular functions related to steroidogenesis and spermatogenesis.

Supplier: EPPENDORF

This convenient set offers safe, ergonomic and lightweight pipettes along with an abundance of high-quality filter tips made from bio-based material (except filter). Package includes 4 Eppendorf Research® plus pipettes and 3840 matching ep Dualfilter T.I.P.S.® BioBased tips, covering a volume range of 0,1 to 1000 μl.

Supplier: MP Biomedicals

MP EcoChrom™ SILICA is used as a suspending and thickening agent in pharmaceutical.A silica-based aerogel was used in the Stardust spacecraft to collect extraterrestrial particles. Silica is also used in the extraction of DNA and RNA due to its ability to bind to the nucleic acids under the presence of chaotropes. As hydrophobic silica it is used as a defoamer component. In hydrated form, it is used in toothpaste as a hard abrasive to remove tooth plaque. SiO2 has a number of distinct crystalline forms (polymorphs) in addition to amorphous forms. In the majority of silicates, the Si atom shows tetrahedral coordination, with 4 oxygen atoms surrounding a central Si atom.

MP EcoChrom™ Silica, the chemical compound silicon dioxide, also known as silica (from the Latin silex), is an oxide of silicon with the chemical formula SiO2 with a mean pore size of 60Å and particles size of 200-500μm. MP silica are free of particles outside the standard range. The irregular shape of MP Silica permits the easy packing of column permeability and plate number. They allow easy switching from one sieve cut to another, offering an easy way to change the chromatographic methods. It has been known for its hardness since ancient times. Silica is most commonly found in nature as sand or quartz, as well as in the cell walls of diatoms.

Supplier: MP Biomedicals

Applications
Taurocholic Acid Sodium Salt is an anionic detergent used for protein solubilization.
Product Description
Taurocholic Acid Sodium Salt is the conjugation product of cholic acid with taurine and the principal constituent of the bile of carnivorous animals.
Biochem/physiol Actions
Non-sulfated bile salt, physiological transport substrate for the bile salt export pump/sister of Pgp (BSEP/spgp), Na(+)/taurocholate cotransporter (NTCP) and MRP3 into the hepatic carnalicular.

Melting Point: 230 °C (decomposes)(Lit.)
Presentation: White Powder
Format: Powder
pH: 6 - 7.5(1% aq soln)
Aggregation Number: 4
Critical Micelle Concentration (CMC): 3-11 mM
Heavy Metals: =20 ppm
Loss on Drying: =7.0%
NOTES: Sodium Cholate : =3.0%
Solubility: Soluble in water (100 mg/mL).
Storage & Handling: Store at Room Temperature (15-30 °C).

Supplier: GERING

HYDROMETER 0,940-1,000 25C 160MM 1 * 1 items

Supplier: GERING

HYDROMETER 1,280-1,340 25C 160MM 1 * 1 items

Supplier: CAMAG

Seal for 25ml and 50ml syringes 1 * 1 items

Supplier: PRECISION DYNAMICS TIMEM

LABELLING TAPE AQUA 25MMX12,7M 1 * 1 Roll