48200 Results for: "6-Bromo-2,3-difluorobenzylamine&pageNo=8"

A cell-permeable cGMP antagonist which is resistant to hydrolysis by cyclic nucleotide phosphodiesterases (Ki=0.5 µM). No metabolic side effects. Significantly more lipophilic and membrane permeant as compared to Rp-cGMPS or Rp-8-Br-cGMPS

Expand 1 Items

AM-630 ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Cannabinoid receptor ligand.

Expand 1 Items

trans-7-Hydroxy-PIPAT maleate ≥98%, white solid

Supplier: ENZO LIFE SCIENCES

Dopamine receptor ligand.

Expand 1 Items

N-(6-Aminohexyl)-5-chloro-1-naphthalenesulphonamide hydrochloride ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Binds to calmodulin, inhibiting Ca²⁺-calmodulin-regulated enzyme activity. It inhibits the Ca²⁺/calmodulin-induced activation of myosin light chain kinase in a concentration dependent manner (IC50=25 µM). Cell permeable.

Expand 1 Items

PK 11195 ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Benzodiazepine receptor ligand.

Expand 1 Items

H-9 HCl ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

An excellent affinity ligand for chromatographic purification of protein kinases. Inhibits protein kinases (Ki's: PKA=1.9 µM; PKC=18 µM; PKG=0.87 µM; MLCK=70 µM).

Expand 2 Items

Phloretin ≥98%

Supplier: ENZO LIFE SCIENCES

PKC inhibitor

Expand 1 Items

Erbstatin analog ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

EGFR inhibitor

Expand 1 Items

Calyculin A ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Inhibitor of PP1 and PP2A

Expand 1 Items

(±)-Blebbistatin ≥98%

Supplier: ENZO LIFE SCIENCES

Inhibitor of non-muscle myosin II

Expand 2 Items

1,9-Pyrazoloanthrone ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Potent, cell permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50=40nM for JNK-1 and JNK-2 and 90nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun, induction of c-Jun transcription and anti CD3-induced apoptosis of CD4+ CD8+ thymocytes.

Expand 2 Items

SB-3CT ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Competitive, mechanism-based inhibitor of matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9). It possesses Ki values in the nanomolar range against the gelatinases (14nM for MMP-2; 600nM for MMP-9), but in the micromolar range against other metalloproteinases (206µM for MMP-1, 15µM for MMP-3, 96µM for MMP-7, and 4µM for ADAM17/TACE). This inhibitor has also been used in vitro, in vivo, and in tissue culture. In vivo, it is metabolized to an even more potent gelatinase inhibitor.

Expand 2 Items

GW 9508 ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

High potency synthetic agonist at GPR40.

Expand 2 Items

Eicosapentaenoyl ethanolamide ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Eicosapentaenoyl ethanolamide ≥98% (by TLC)

Expand 1 Items

α-Hydroxyfarnesylphosphonic acid (synthetic) ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Potent inhibitor of farnesyltransferase in isolated enzyme assays (IC50=30 nM) and in whole cells. Inhibition of farnesyltransferase is selective over geranylgeranyltransferase I and II (IC50=35.8 µM and 67 µM respectively). α-Hydroxyfarnesylphosphonic acid inhibited (1 µM) Ras processing in Ha-ras-transformed NIH 3T3 fibroblasts.

Expand 1 Items

AAL-993 ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES

Highly potent inhibitor of VEGFR-1 (IC50=130nM), VEGFR-2 (IC50=23nM) and VEGFR-3 (IC50=18nM). At higher concentrations it inhibits PDGFR-β (640nM), c-Kit (236nM) and CSF-1R (380nM).