68475 Results for: "6-Amino-6-deoxy-D-glucopyranose,+hydrochloride"

Supplier: ProSci Inc.

MEK5 (also known as MKK5) is a dual specificity serine/threonine protein kinase belonging to the MAP kinase kinase family. MEK5 has been shown to specifically activate ERK5 (Zhou et al., 1995) whereas MEK5 itself is regulated by MEKK3 (Chao et al., 1999). An important link between MEK5 and metastatic prostrate cancer has been demonstrated (Mehta et.al., 2003). Dual phosphorylation of Ser311 and Thr315 have been implicated in cell proliferation (Cameron et al., 2004).

Supplier: ProSci Inc.

Arginine methylation is an irreversible post translational modification which has only recently been linked to protein activity. At least three types of PRMT enzymes have been identified in mammalian cells. These enzymes have been shown to have essential regulatory functions by methylation of key proteins in several fundamental areas. These protein include nuclear proteins, IL enhancer binding factor, nuclear factors, cell cycle proteins, signal transduction proteins, apoptosis proteins, and viral proteins. The mammalian PRMT family currently consists of 7 members that share two large domains of homology. Outside of these domains, epitopes were identified and antibodies against all 7 PRMT members have been developed.

Supplier: MP Biomedicals

Soluble in distilled water. Soluble in 0,1 M potassium phosphate buffer, pH 6,0 (monobasic potassium phosphate adjusted to pH 6,0 with 1,0 M potassium hydroxide) (10 mg/ml yields a clear, red-brown solution). Solutions of HRP can be kept refrigerated for up to a year while maintaining practically undiminished activity. Optimal pH is 6,0 to 6,5 (activity at pH 7,5 is 84% of the maximum). The enzyme is most stable in the pH range of 5,0 to 9,0 (Lit.).

Supplier: Thermo Fisher Scientific

Thermo Scientific Pierce DSS, also called disuccinimidyl suberate, is noncleavable and membrane permeable crosslinker that contains an amine-reactive N-hydroxysuccinimide (NHS) ester at each end of an 8-carbon spacer arm.

Supplier: Boster Bio

Rabbit IgG polyclonal antibody for Ataxin-3(ATXN3) detection. Tested with WB, IHC-P in Human;Rat.

Supplier: Boster Bio

Rabbit IgG polyclonal antibody for Transcription factor A, mitochondrial(TFAM) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

Supplier: Boster Bio

Rabbit IgG polyclonal antibody for Programmed cell death 1 ligand 1(CD274) detection. Tested with WB in Human;Mouse;Rat.

Supplier: MP Biomedicals

Purity: 98% 1 * 1 g

Supplier: MP Biomedicals

Anti-bacterial Agent 1 * 5 g

Supplier: MP Biomedicals

UN2811III 1 * 50 mg

Supplier: MP Biomedicals

Purity: 98% 1 * 25 g

Supplier: MP Biomedicals

Purity: 98% 1 * 5 g

Supplier: MP Biomedicals

Anti-bacterial Agent 1 * 25 g

Supplier: MP Biomedicals

Anti-bacterial Agent 1 * 50 g

Supplier: LGC Standards PROMOCHEM

(2S,3S)-5-[2-(Dimethylamino)ethyl]-3- hydroxy-2-(4-methoxyphenyl)-2,3- dihydro-1,5-benzothiazepin-4(5H)-one 1 * 25 mg

Supplier: LGC Standards PROMOCHEM

(2S,3S)-3-Hydroxy-2-(4- methoxyphenyl)-2,3-dihydro-1,5- benzothiazepin-4(5H)-one 1 * 25 mg

Supplier: Cayman Chemical

Rauwolscine is a natural alkaloid that acts as a selective and reversible 2-adregenergic receptor antagonist (Ki = 12 nM).{25653} I t is a stereoisomer of yohimbine, which potently antagonizes both 1- and 2-adrenergic receptors.{25653} Rauwolscine 1 * 100 mg

Supplier: Cayman Chemical

Rauwolscine is a natural alkaloid that acts as a selective and reversible 2-adregenergic receptor antagonist (Ki = 12 nM).{25653} I t is a stereoisomer of yohimbine, which potently antagonizes both 1- and 2-adrenergic receptors.{25653} Rauwolscine 1 * 250 mg

Supplier: Cayman Chemical

Atipamezole is an imidazole that potently antagonizes the 2-adrenoceptor (Ki = 1.6 nM).{25705,25706} It shows selectivity over the 1-adrenoceptor (Ki = 13,300 nM) and is a poor antagonist at a wide variety of other receptors and channels.{25706} Th 1 * 5 mg

Supplier: G-Biosciences

Tetracycline is a bacteriostatic antibiotic with activity against both gram-positive and gram-negative bacteria. Within the cell tet racycline binds reversibly to the 30S subunit of the ribosome, preventing the binding of aminoacyl tRNA and inhibitin 1 * 25 g

Supplier: Cayman Chemical

Rauwolscine is a natural alkaloid that acts as a selective and reversible 2-adregenergic receptor antagonist (Ki = 12 nM).{25653} I t is a stereoisomer of yohimbine, which potently antagonizes both 1- and 2-adrenergic receptors.{25653} Rauwolscine 1 * 50 mg

Supplier: Cayman Chemical

Atipamezole is an imidazole that potently antagonizes the 2-adrenoceptor (Ki = 1.6 nM).{25705,25706} It shows selectivity over the 1-adrenoceptor (Ki = 13,300 nM) and is a poor antagonist at a wide variety of other receptors and channels.{25706} Th 1 * 25 mg

Supplier: Cayman Chemical

Atipamezole is an imidazole that potently antagonizes the 2-adrenoceptor (Ki = 1.6 nM).{25705,25706} It shows selectivity over the 1-adrenoceptor (Ki = 13,300 nM) and is a poor antagonist at a wide variety of other receptors and channels.{25706} Th 1 * 10 mg

Supplier: Cayman Chemical

Atipamezole is an imidazole that potently antagonizes the 2-adrenoceptor (Ki = 1.6 nM).{25705,25706} It shows selectivity over the 1-adrenoceptor (Ki = 13,300 nM) and is a poor antagonist at a wide variety of other receptors and channels.{25706} Th 1 * 50 mg

Supplier: ProSci Inc.

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-2 is found in a wide range of neuronal and non-neuronal cells including dendrites and axon terminals as well as epithelial cells and cells forming the pia and arachnoid complex (Conti et al., 1999).

Supplier: ProSci Inc.

DR4 Antibody: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4). The ligand for this novel death receptor has been identified and termed TRAIL2, 3, which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF-kappa B activation in many tissues and cells.

Supplier: LGC Standards PROMOCHEM

(2S,3S)-2-(4-Methoxyphenyl)-4-oxo-2,3,4,5- tetrahydro-1,5-benzothiazepin-3-yl Acetate 1 * 25 mg

Supplier: LGC Standards PROMOCHEM

(2S,3S)-2-(4-Methoxyphenyl)-5-[2-(methylamino)ethyl]-4-oxo-2,3,4 ,5-tetrahydro-1,5-benzothiazepin-3-yl Acetate 1 * 25 mg

Supplier: ProSci Inc.

The Ras pathway is a critical signal transduction cascade involved in regulating cellular proliferation, differentiation, survival, and oncogenic transformation. Members of the Raf serine/threonine kinase family are key intermediates in this cascade, functioning to relay signals from activated Ras to the downstream protein kinases MEK and ERK (Marshall, 1996). Previous studies have shown that phosphorylation is required for Raf-1 activation (Dhillon and Kolch, 2002; Chong et al., 2003). Recent work has demonstrated that phosphorylation also regulates the downregulation of Raf (Dougherty et al., 2005) with two sites participating: Ser301 and Ser642.

Supplier: ProSci Inc.

Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors, TRalpha1, TRalpha2, TRbeta1 and TRbeta2. TRalpha1, TRbeta1 and TRbeta2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).