48200 Results for: "5-Cyclopropylpicolinic+acid+hydrochloride&pageNo=8"

Supplier: ENZO LIFE SCIENCES

Inhibitor of PPARα activation. Inhibits 5-lipoxygenase-activating protein (FLAP) and leukotriene biosynthesis. Binds to FLAP with high affinity and prevents the activation of 5-lipoxygenase. IC50’s for leukotriene biosynthesis: 2.5 nM in intact leukocytes; 1.1 µM in whole blood. Induces apoptosis through the mitochondrial pathway.

Supplier: ENZO LIFE SCIENCES

Potent and selective inhibitor of GSK-3β (IC50=34nM). Stimulates glycogen synthesis in human liver cells and mimics other actions of insulin. Protects primary neurons from death induced by PI-3 kinase pathway inhibition suggesting therapeutic potential in neurodegenerative diseases and stroke. Reduces pulmonary inflammation and fibrosis in a mouse model.

Supplier: ENZO LIFE SCIENCES

Weak histone deacetylase (HDAC) inhibitor. Induces differentiation, growth arrest and apoptosis in a number of cell lines. Protects against cerebral ischemic injury and displays neuroprotective effect in a mouse model of Huntington’s disease. Anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation. Shows chemical chaperone activity.

Supplier: ENZO LIFE SCIENCES

A potent and selective inhibitor of Cdc25 phosphatase (Ki's for Cdc25A, B and C are 32, 96 and 40 nM respectively). NSC-95397 inhibits the growth of several human tumor cell lines and blocks G2/M cell cycle transition.

Supplier: ENZO LIFE SCIENCES

GPR119 activator.

Supplier: ENZO LIFE SCIENCES

Blocks lipid peroxidation

Supplier: ENZO LIFE SCIENCES

Potent inhibitor of farnesyltransferase in isolated enzyme assays (IC50=55nM) but is inactive in whole cells. Inhibition of farnesyltransferase is selective over geranylgeranyltransferase I and II (IC50=92µM and 34µM respectively).

Supplier: ENZO LIFE SCIENCES

HMG-CoA reductase inhibitor

Supplier: ENZO LIFE SCIENCES

A novel geldanamycin fluorescent probe that may be used in a fluorescence polarization assay for HSP90 inhibitors. May also be used for detection of cell surface HSP90.

Supplier: ENZO LIFE SCIENCES

Inhibitor of a variety of serine/threonine and tyrosine kinases, like protein kinase C (PKC), cyclic AMP-dependent protein kinase (PKA), S6 kinase, Akt (protein kinase B; PKB), epidermal growth factor receptor (EGFR) tyrosine kinase activity and others including KDR, VEGFR, PDGFR, c-kit and other receptor tyrosine kinases. Potently inhibits FLT-3 kinase including mutant forms found in acute myeloid leukemia in vitro and in vivo. Apoptosis inducer. Showed broad antiproliferative activity against various tumor cell lines. Selectively inhibits T lymphocyte production of TNF-α. Upregulates endothelial nitric oxide synthase (eNOS; NOS III). Abrogates tumor angiogenesis in vivo.

Supplier: Apollo Scientific

6,8-Dichloro-9H-purin-2-amine 250mg pack 1 * 250 mg

Supplier: Apollo Scientific

3,3'-Di-tert-butyl-2'-((4,8-di-tert-butyl-2,10-dimethoxydibenzo[d,f][1,3,2]dioxaphosphepin-6-yl)oxy)-5,5'-dimethoxy-[1,1'-biphenyl]- 2-ol 1g pack 1 * 1 g

Supplier: Apollo Scientific

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-((2,2,10,10-tetramethyl-4,8-dioxo-3,9-dioxa-5,7-diazaundecan-6-ylidene)amino)pen tanoic acid 250mg pack 1 * 250 mg

Supplier: ENZO LIFE SCIENCES

Mixture of alamethicin homologs. Membrane permeabilizing antibiotic. Applications include increasing [32P] incorporation into phosphatidylinositol 4-phosphate and permeabilization of sarcoplasmic reticulum vesicles. Causes fusion of lipid vesicles.

Supplier: Thermo Fisher Scientific

1-Ethyl-1,3-dihydro-2H-benzimidazol-2-one 98%

Supplier: MIELE

Injector module A 301/4 for optimum loading of laboratory glassware – can be equipped with 18 nozzles 1 * 1 items

Supplier: Apollo Scientific

Benzyl 3,8-diazabicyclo[3.2.1]octane-8-carboxylate 100mg pack 1 * 100 mg

Supplier: Apollo Scientific

1,8-Naphthalimide 250g pack 1 * 250 g

Supplier: Apollo Scientific

1,8-Naphthalimide 25g pack 1 * 25 g

Supplier: Apollo Scientific

1,8-Dihydroxyanthracen-9(10H)-One 25g pack 1 * 25 g

Supplier: Apollo Scientific

1,8-Bis(Methylamino)-3,6-Dioxaoctane 100mg pack 1 * 100 mg

Supplier: Apollo Scientific

2,6-Dibromo-4,8-Bis[(2-Ethylhexyl)Oxy]-Benzo[1,2-B:4,5-B’]Dithiophene 5g pack 1 * 5 g

Supplier: Apollo Scientific

2,6-Dibromo-4,8-Bis[(2-Ethylhexyl)Oxy]-Benzo[1,2-B:4,5-B’]Dithiophene 100mg pack 1 * 100 mg

Supplier: Apollo Scientific

6,8-Dimethyl-3,4-dihydro-2H-benzo[b][1,4]oxazine 100mg pack 1 * 100 mg

Supplier: Apollo Scientific

8-Ethyl-2-methanethio-8H-pyrido[2,3-d]pyrimidin-7-one 50mg pack 1 * 50 mg

Supplier: Apollo Scientific

(R)-4-Benzyl-2-(1,8-naphthyridin-2-yl)-4,5-dihydrooxazole 250mg pack 1 * 250 mg

Supplier: ENZO LIFE SCIENCES

Selective inhibitor of cGMP-specific phosphodiesterase (PDE V, IC50=19 nM).

Supplier: ENZO LIFE SCIENCES

Selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III, IC50=0.6µM).

Supplier: ENZO LIFE SCIENCES

Prostanoid receptor ligand.

Supplier: ENZO LIFE SCIENCES

A highly potent, cell-permeable inhibitor of cathepsin K (IC50=51 nM).