145764 Results for: "5-Cyclopropylpicolinic+acid+hydrochloride&pageNo=10&view=list"

Supplier: ProSci Inc.

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gamma;s, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. It has recently been suggested that PKCepsilon regulates the sensitivity of GABAA alpha1beta2gamma2 receptors to ethanol and benzodiazepines through phosphorylation of serine 327 in the large intracellular loop of gamma2 (Qi et al., 2007)

Supplier: ProSci Inc.

Clone MTC02 antibody recognises a unique 60 kDa antigen that is present only on mitochondria in human cells. It is a part of a panel of reagents which recognises subcellular organelles or compartments. These markers may be useful in identification of these organelles in cells, tissues, and biochemical preparations. This antibody recognises an antigen associated with the mitochondria specific to human cells alone. MTC02 mAb can be used to stain the mitochondria in cell or tissue preparations and can be used as a marker in subcellular fractions. The antibody produces a spaghetti-like pattern in normal and malignant cells and may be used to stain mitochondria of cells in fixed or frozen tissue sections. It can also be used with paraformaldehyde fixed frozen tissue or cell preparations. MTC02 antibody is an excellent marker for human cells in xenographic model research. It reacts specifically with human cells, including neurons and embryonic stem cells.

Supplier: CHIRAL TECHNOLOGIES

COLUMN CHIRALPAK WH 250X4.6MM 10µM 1 * 1 items

Supplier: CHIRAL TECHNOLOGIES

COLUMN CHIRALPAK WH 50X4.6MM 10µM 1 * 1 items

Supplier: OMNIFIT

Frits, ptfe, 40 micron for 10mm endpieces 1 * 20 items

Supplier: Hospidex

Microsyringe 10µl with plunger and interchangeable needle 1 * 1 items

Supplier: LABTECH

The POLARstar Omega is high speed full spectrum absorbance multidetection microplate reader with simultaneous dual emission detection and fluorescence polarisation. Modes include standard fluorescence, time-resolved fluorescence, fluorescence polarisation (anisotropy), UV/Vis absorbance (OD) measurement of complete spectra or individual wavelengths and high performance luminescence.

Supplier: Amarell

Viscometer-Therm., similar Vogel-Ossag, similar DIN 12785, +90+150:0,2C, enclosed scale, capillary tube specially coated inside, w ith non-wetting blue special liquid, 470mm long, lower part solid stem 200x5mm, 208mm immersion, Richter-top finish, null

Supplier: SARSTEDT

HOLDER TUBE WITH CLIP 10CM 1 * 15 items

Supplier: SAMCO

PASTEUR PIPETTE 7,7 mL, POLYETHYLENE 1 * 500 items

Supplier: HIRSCHMANN

Suction tube . 400 mm for em-dispenser up to 10ml 1 * 1 items

Supplier: TRESTON

Middle plate 90-130/100 L=100 1 * 1 items

Supplier: Poulten & Graf

BURETTE PTFE S/COCK CLASS A 10MLX0.02ML 1 * 1 items

Supplier: CERTOCLAV

Chamber with handles, base MC 12 L 1 * 1 items

Supplier: ProSci Inc.

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. [UniProt].

Supplier: ProSci Inc.

ACTH (or Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This mAb is specific to CLIP (aa 25-39) and does not react with Synacthen (aa 1-24). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.

Supplier: ProSci Inc.

Villin (VIL1) is an epithelial cell-specific Ca2+-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination. [UniProt].

Supplier: Portwest

This superb 5-in-1 jacket system is adaptable for any work situation. Outer jacket features 2 large roomy pockets, stud adjustable cuffs and concealed attached roll-away hood. Inner jacket has fluorescent fleece sleeves, comfortable knitted cuffs and 2 side pockets. Both the inner and outer jacket have full EN ISO 20471 Class 3 certification for maximum high visibility protection and safety.

Supplier: Thermo Fisher Scientific

Thermo Scientific Pierce EDC is a carboxyl- and amine-reactive zero-length crosslinker. EDC reacts with a carboxyl group first and forms an amine-reactive O-acylisourea intermediate that quickly reacts with an amino group to form an amide bond with release of an isourea by-product. The intermediate is unstable in aqueous solutions and so two-step conjugation procedures rely on N-hydroxysuccinimide (NHS) for stabilization. Failure to react with an amine will result in hydrolysis of the intermediate, regeneration of the carboxyl, and release of an N-substituted urea. A side reaction is the formation of an N-acylurea, which is usually restricted to carboxyls located in hydrophobic regions of proteins.

Supplier: BIOPREMIER

Food safe kits provide a simple, reliable, and rapid procedure for detecting the presence of a specific pathogenic bacteria. The assay is based on 5’ nuclease Real-Time PCR reactions to amplify a unique genomic sequence in the target microorganism. PCR is a method used to amplify a specific DNA sequence which is typically amplified in a reaction containing a thermostable DNA polymerase, nucleotides, and primers complementary to the target sequence. When this solution is heated, the DNA molecule denatures, separating into two strands. As the solution cools, the primers anneal to the target sequences in the separated DNA strands and the DNA polymerase synthesises a new strand by extending the primers with nucleotides, creating a copy of the DNA sequence (amplicons). When repeated, this cycle of denaturing, annealing, and extending exponentially increases the number of target amplicons. In Real-Time PCR, specific fluorescent probes are used to detect the amplified DNA by hybridising with amplicons. These probes are linked to a fluorophore on one end and a quencher that suppresses fluorescence on the other. If the target sequence is present during the PCR, amplification occurs and the probe is degraded, resulting in fluorescence increase. Fluorescence is measured by a detector and the associated software plots the fluorescence intensity versus number of cycles, allowing the determination of the presence or absence of the target organism.

Supplier: GERING

HYDROMETER BAUME 40-50 0,1 20C 1 * 1 items

Supplier: MEMMERT

Controller module EXCELLENT with blind for model 500-800 1 * 1 items

Supplier: Corning

Corning® Synthegel™ 3D matrices are chemically defined peptides that self assemble into nanofibers which crosslink to form tuneable hydrogels. These hydrogels provide a robust and reproducible microenvironment for 3D culture of physiological spheroids and hiPS cells. The Synthegel™ matrix kits provide negligible variability and a more controlled substrate for in vivo-like 3D cell culture. Such a platform is needed for cancer research, stem cell research, and drug screening in a 3D format.

Supplier: BTX

The High Throughput ECM™ 830 system offers a multi-well electroporation technology for processing multiple samples in seconds. Using the HT multi-well plates instead of traditional cuvettes, the researcher can transition from a single cuvette to either a 25-well or 96-well electroporation plate by using one simple plate handler. This increases yields and the number of experiments run in a single day. Experiments take seconds to run, allowing for quick and efficient optimisation of the electrical and biological parameters. Once optimised, samples are rapidly processed increasing yields and saving valuable time and money.

Supplier: RPB SAFETY

The RPB PX5 is a battery powered air purifying respirator fan unit which draws in contaminated air from the wearer's immediate vicinity, passing it through internal filters, and supplying the filtered air to an approved RPB loose fitting respirator head top.

Supplier: SciLabware

BOTTLE REAGENT WIDE NECK 10L 1 * 1 items

Supplier: Alla France

THERMOMETER WO PROT SLEEVE -50/+50 1C 1 * 1 items

Supplier: DEUTSCH NEUMANN

HOSE PVC 10MM THICKN 2MM 1 * 100 m

Supplier: TRESTON

Hook R1, L50 /20kg (5pcs),L50 /20kg (5pcs) 1 * 1 items

Supplier: Abnova

Recombinant protein, birc1( np_004527, 1294 a.a. - 1403 a.a.) partial recombinant protein with gst tag. 1 * 2 µG