Supplier: GERHARDT

MAINS CABLE AKE 3X1MM 1.5M 1 * 1 items

Supplier: Honeywell Safety

SLEEVES HYPALON 1 * 1 items

Supplier: MOINEAU

MULTIMETER DIGITAL 932SI TRUE RMS 1 * 1 items

Supplier: VACUUBRAND

Pirani-Controller CVC 3000 Set with KF DN 16, for example for RE/RZ 2.5 and RE/RZ 6 with VSP 3000, Vacuum-Valve VV-B 15C, T-Connection, SW DN 15 and more connection parts 1 * 1 SET

Supplier: TECHNI GLOVE

Nitrile GL30cmTechniGlove TN1201W tacky Size S 1 * 1.000 items

Supplier: Amarell

Thermometer similar to IP 44 C, solid stem, white backed, 15+121:0,5C, red special liquid, durable pigment, suitable for government calibration 1 * 1 items

Supplier: SMEG

SINGLE-PHASE ELECTRIC CONNECTION 1 * 1 items

Supplier: MEMMERT

This steriliser complies with all relevant standards and regulations for medical products and guarantees reliable programme sequences, irrespective of the load and chamber volume. Especially due to the SetpointWAIT function the validation of this hot air steriliser is possible anytime. The SetpointWAIT function ensures that the programme is only continued when the setpoint temperature has been reached. Precisely maintaining the sterilisation time and completely killing off even highly resistant microorganisms is therefore guaranteed at all times, irrespective of the sterilisation load and chamber volume. This feature can also be used with additional, freely positionable PT100 temperature sensors. In this case, sterilisation only begins when the setpoint temperature has been reached at all measurement points – that is, in the load. For the special application of depyrogenisation, the hot-air steriliser is ideal.

Supplier: Biotium

Viability PCR With PMA and PMAxx™ dyes

Supplier: ZWIEBEL

BRASS MASS 10G WITH CERTIFICATE 1 * 1 items

Supplier: DELTALAB

VACUUM PIPETTE GREEN 1 * 1 items

Supplier: EPPENDORF

PISTON 0,5-10UL 1 * 1 items

Supplier: ProSci Inc.

CAPN10 is the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and located within the NIDDM1 region. Multiple alternative transcript variants encoding different isoforms have been described for this gene.

Supplier: ProSci Inc.

EphrinB proteins are thought to play key roles in cellular functions as diverse as neuronal migration and blood vessel development (Flanagan and Vanderhaeghen, 1998; Dufour et al., 2003; Oike et al., 2002). EphrinB molecules expressed at the membrane surface bind to the EphB family receptors on target cells during cell-to cell contact. This interaction leads to cell signaling in the target cell but also generates a reverse signal in the cell expressing EphrinB on its surface. This reverse signaling event is thought to be critical for vessel maturation and neuronal development. Importantly, tyrosine phosphorylation of EphrinB is thought to be a critical component of this reverse signaling event (Palmer et al., 2002). Recent work demonstrated that Tyr331 of EphrinB was phosphorylated in HEK293 cells after stimulation by the soluble EphB2 receptor tyrosine kinase (Kalo et al., 2001).

Supplier: Thermo Orion

The Orion™ Star™ A112 conductivity benchtop meter is ideal for a wide range of applications and advanced conductivity analysis in the lab. It reliably measures conductivity, total dissolved solids, salinity, resistivity and temperature values.

Supplier: Thermo Orion

This portable conductivity meter is designed for a wide range of conductivity, total dissolved solids (TDS), salinity, resistivity and temperature testing and field applications. The meter is suitable for use in the most demanding locations thanks to its IP 67-rated housing.

Supplier: SIOEN

This multifunctional, water- and wind-proof garment consists of a light rain jacket in a very breathable material and a smart softshell jacket with detachable sleeves. Made from highly breathable Siopor® Ultra fabric consisting of 100% polyester with 100% PU coating, with fixed mesh lining and knitted wind cuffs in the sleeves.

Supplier: Bioss

Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. GRB14 is a potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.

Supplier: OMEGA BIO-TEK

E-Z® 96 DNA plates are silica glass fibre plates can bind up to 50 μg of genomic DNA or 20 μg of plasmid DNA per prep. Each well has a capacity of 1 ml and the plates are semi skirted. E-Z 96 DNA plates can be processed in vacuum manifolds and/or by centrifugation.

Supplier: ProSci Inc.

T-Cell Intracellular Antigen-1 is a cytoplasmic granule-associated protein expressed in lymphocytes processing cytolytic potential. It is a member of an RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognises poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15 kDa protein thought to be derived from the carboxyl terminus of the 40 kDa product by proteolytic processing. TIA-1 antibody labels cytotoxic T cells and natural killer cells (NK cells). It is also expressed in T-cell lymphoma, large granular lymphocyte (LGL) leukemia and hairy cell leukemia. TIA1 expression in T-cell malignancies may help in differentiating LGL leukemia (high expression) from T-cell lymphocytosis and other T-cell diseases (low expression). TIA1 may also be used to label tumor-infiltrating lymphocytes in the study of immune response to malignancies.

Supplier: FRISTADS KANSAS

These high visibility trousers are made of 54% modacrylic, 44% cotton and 2% anti-static fibre. Reinforced with 79% cotton FR, 20% polyamide, 1% anti-static fibre. They provide protection against chemicals, heat, flames and electric arcs.

Supplier: WATERS

COLUMN ORB SAX 80Å 10µM 4.6M 1 * 1 items

Supplier: FRITSCH

Test Sieve 400/65 mm, mesh = 0.16 mm ISO 3310-1 1 * 1 items

Supplier: Bioss

Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. GRB14 is a potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.

Supplier: MEMMERT

These sterilisers comply with all relevant standards and regulations for medical products, and guarantee reliable program sequences, irrespective of the load and chamber volume. With the SetpointWAIT function validation of this hot air steriliser is possible anytime. The SetpointWAIT function ensures that the program only continues when the set point temperature has been reached. Precisely maintaining the sterilisation time and thus completely killing off even highly resistant microorganisms is, therefore, guaranteed at all times, irrespective of the sterilisation load and chamber volume. This feature can also be used with additional, freely positionable PT100 temperature sensors. In this case, sterilisation only begins when the set point temperature has been reached at all measurement points – that is, in the load. For special applications such as depyrogenisation, this hot air steriliser is absolutely ideal. SFplus models are equipped with TwinDISPLAY.

Supplier: LABCONCO

FLUORESCENT LAMP REPLACEMENT 1 * 1 items

Supplier: Agilent

Syringe 10Ul Rn 23Ga. 1 * 1 items

Supplier: ProSci Inc.

The antibody recognises a single chain glycoprotein of 105/120 kDa, identified as CD30/Ki-1. CD30 is synthesised as a 90 kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120 kDa glycoprotein. In Hodgkin’s disease, CD30 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. It is also expressed by the tumor cells of a majority of anaplastic large cell lymphomas as well as by a varying proportion of activated T and B cells. This antibody distinguishes large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the CD30 positive lymphomas lack the leukocyte common antigen (CD45).

Supplier: ProSci Inc.

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.

Supplier: Thermo Fisher Scientific

Thermo Scientific Pierce Sulfo-SMCC, No-Weigh Format is a water-soluble, amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length cyclohexane spacer arm (8.3 angstroms).