145746 Results for: "5-Cyclopropylpicolinic+acid+hydrochloride&pageNo=10&view=list"

Supplier: BANDELIN-ELECTRONIC

SONOREX SUPER RK 512 H, ULTRASONIC BATH, 35 KHZ, 230 V~ 50/60 HZ, ID 300X240X200 MM 13 L, S/S TIMER 1-15 MIN AND CONTINUOUS, HEAT ING 30-80°C (86-176°F), DRAIN BALL COCK 1/2 , ULTRASONIC PEAK OUTPUT 860 W, HF-OUTPUT: 215 WEFF. 1 * 1 items

Supplier: Corning

10µl Pre-Sterilized Hamilton CO-RE Style Liquid Level Sensing Filter Tip. 96 Tips per Rack, 5 Racks/pack, 12 packs/case 1 * 5.760 items

Supplier: SARSTEDT

MICRO CAPILLARY 1?L 1 * 1 Each

Supplier: AGILENT

The StrataPrep PCR purification kits provide a rapid method to simultaneously purify PCR products from PCR primers, unincorporated nucleotides, buffer components, and enzymes.

Supplier: Bioss

Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. GRB14 is a potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.

Supplier: Bioss

Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. GRB14 is a potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.

Supplier: Bioss

Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. GRB14 is a potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.

Supplier: BANDELIN-ELECTRONIC

SONOREX SUPER RK 1028 C, ULTRASONIC BATH, 35 KHZ, 230 V 50/60 HZ, ID 500X300X300 MM 45 L, S/S AISI 316 TI TIMER 1-15 MIN AND CON TINUOUS, DRAIN BALL COCK 1/2 , ULTRASONIC PEAK OUTPUT 2000 W, HF-OUTPUT: 500 WEFF. 1 * 1 items

Supplier: BANDELIN-ELECTRONIC

SONOREX SUPER RK 514 H, ULTRASONIC BATH, 35 KHZ, 230 V~ 50/60 HZ, ID 325X300X150 MM 13,5 L, S/S TIMER 1-15 MIN AND CONTINUOUS, HE ATING 30-80°C (86-176°F), DRAIN BALL COCK 1/2 , ULTRASONIC PEAK OUTPUT 860 W, HF-OUTPUT: 215 WEFF. 1 * 1 items

Supplier: IBI SCIENTIFIC

QS710 CASTING SYSTEM (TRAY AND FIXTURE) 1 * 1 Each

Supplier: VWR Chemicals

VWR® dehydrated culture media that has been granulated offers both convenience and safety benefits. The correct dissolution of culture media is critical to achieving the best performance. Granulated culture media saves time in the preparation of ready to use culture media. In addition, granulation reduces dust generation, so handling the product is more pleasant and safer for the user, making it a much cleaner and safer working environment.

Supplier: PURITAN MEDICAL

SWAB NON-STERILE COTTON TIP 15.2CM LENGT 1 * 10.000 items

Supplier: Amarell

Density hydrometer, 1,100-1,200:0,001g/cm , ref. temp. 20C, with therm., 0+40:1C, 350mm long, special liquid 1 * 1 items

Supplier: Orflo

The Moxi V™ provides a combination of volumetric cell sizing (particle sizer) with simultaneous fluorescence (flow cytometer) to provide the most accurate cell counts, size, and viability in the industry. Specifically, the Moxi V™ employs the Coulter Principle to precisely measure the volumetric particle size of each particle for exact size measurements down to 3 µm in diameter (14 fl volume), easily distinguishing between cells and debris. The system is also equipped with a 532 nm laser and a 561 nm/LP detection channel for robust cell viability analysis.

Supplier: ProSci Inc.

PECAM-1, or platelet endothelial cell adhesion molecule-1, also called CD31, is made up of six extracellular immunoglobulin-like domains, a single transmembrane domain, and a cytoplasmic domain containing serine and tyrosine residues that when phosphorylated, activate the molecules signaling function. It is expressed on platelets, monocytes, neutrophils, bone marrow macrophage and dendritic cells precursors, and at the intracellular junction of endothelial cells. PECAM-1, on the endothelial lining of blood vessels, helps maintain the vascular barrier. In response to inflammatory mediators, the endothelial pull away from each other allowing fluid, inflammatory cells and proteins into the extravascular space. The inflammatory response fades as adhesion of neighboring cells increase. PECAM-1 also plays an important role in angiogenesis, promoting endothelial cell motility, junctional development and capillary morphogenesis.

Supplier: ProSci Inc.

The transcription factor Forkhead-box A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha, is a member of the FOX class of transcription factors. HNF-1 (alpha and beta), HNF-3 (alpha, beta and gamma), HNF-4 (alpha and gamma), and HNF-6 compose, in part, a homeoprotein family designated the hepatocyte nuclear factor family. The various HNF-1 isoforms regulate transcription of genes in the liver as well as in other tissues such as kidney, small intestine and thymus. FOXA1 is expressed in normal breast ductal epithelium and other epithelium in different organs, such as lung, pancreas, bladder, prostate, and colon. Recently, FOXA1 has been shown to be a major determinant of estrogen-ER activity and endocrine response in breast cancer cells. FOXA1 expression correlates with estrogen receptor (ER)-positivity, especially in luminal subtype A breast cancers, which is associated with favorable prognosis. FOXA1 is useful in the sub-classification of breast carcinomas.

Supplier: ProSci Inc.

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.

Supplier: ProSci Inc.

The activating transcription factor ATF-2 (also called CRE-BP1) binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins. ATF-2 has been implicated in the transcriptional regulation of a number of genes including cytokines, cell cycle control and apoptosis. Various forms of cellular stress, including inflammatory cytokines and UV irradiation, stimulate the transcriptional activity of ATF-2. Stress induced ATF-dependent transcription is dependent on phosphorylation of ATF. Serine 490 and serine 498 are novel phosphorylation sites on ATF that have recently been identified. In addition, ATF2 is particularly abundant in the brain and the ATF2 family of transcription factors is considered important substrates of signals upstream of the activation of genes associated with neuronal growth and differentiation. ATF expression has also been linked to the depression in humans.

Supplier: ProSci Inc.

14-3-3 proteins are a family of highly conserved proteins that appear to have multiple roles in cell signaling (Bridges and Moorhead, 2005). The proteins are abundantly expressed in the brain and have been detected in the cerebrospinal fluid of patients with different neurological disorders (Berg et al., 2003). 14-3-3 proteins bind protein ligands that are typically phosphorylated on
serine or threonine residues and regulate the functions of these binding partners by a number of different mechanisms (Silhan et al., 2004; Dougherty and Morrison, 2004). The14-3-3 proteins affect a diverse array of cellular processes including the cell cycle and transcription, signal transduction and intracellular trafficking. These functions of 14-3-3 proteins are facilitated by, if not dependent on, its dimeric structure. Recent work has demonstrated that the dimeric status of the 14-3-3 protein is regulated by site-specific serine phosphorylation (Woodcock et al., 2003).

Supplier: Sartorius

Arium® pro Type I water purification systems are designed for sophisticated users to meet all their requirements for reagent grade water, needed both for critical applications and routine analyses. Different versions are available for reliable and optimal analytical results.

Supplier: BANDELIN-ELECTRONIC

SONOREX SUPER RK 103 H, ULTRASONIC BATH, 35 KHZ, 230 V~ 50/60 HZ, ID 240X140X150 MM 4 L, S/S TIMER 1-15 MIN AND CONTINUOUS, HEATI NG 30-80°C (86-176°F), DRAIN BALL COCK 1/4 , ULTRASONIC PEAK OUTPUT 560 W, HF-OUTPUT: 140 WEFF. 1 * 1 items

Supplier: BANDELIN-ELECTRONIC

SONOREX SUPER RK 156 BH, ULTRASONIC BATH, 35 KHZ, 230 V~ 50/60 HZ, ID 500X140X150 MM 9 L, S/S TIMER 1-15 MIN AND CONTINUOUS, HEAT ING 30-80°C (86-176°F), DRAIN BALL COCK 1/4 , ULTRASONIC PEAK OUTPUT 860 W, HF-OUTPUT: 215 WEFF. 1 * 1 items

Supplier: BANDELIN-ELECTRONIC

SONOREX SUPER RK 514 BH, ULTRASONIC BATH, 35 KHZ, 230 V~ 50/60 HZ, ID 325X300X200 MM 18,7 L, S/S TIMER 1-15 MIN AND CONTINUOUS, H EATING 30-80°C (86-176°F), DRAIN BALL COCK 1/2 , ULTRASONIC PEAK OUTPUT 860 W, HF-OUTPUT: 215 WEFF. 1 * 1 items

Supplier: BANDELIN-ELECTRONIC

SONOREX SUPER RK 1028 H, ULTRASONIC BATH, 35 KHZ, 230 V~ 50/60 HZ, ID 500X300X200 MM 28 L, S/S TIMER 1-15 MIN AND CONTINUOUS, HEA TING 30-80°C (86-176°F), DRAIN BALL COCK 1/2 , ULTRASONIC PEAK OUTPUT 1200 W, HF-OUTPUT: 300 WEFF. 1 * 1 items

Supplier: LGC Standards PROMOCHEM

CRM VAPOUR PRESSURE ASTM D5191 104.4 KPA 1 * 100 mL

Supplier: Thermo Scientific

ANGLE 1 * 1 items

Supplier: Thermo Fisher Scientific

CYLINDER 1 * 1 items

Supplier: BANDELIN-ELECTRONIC

SONOREX SUPER RK 1040, ULTRASONIC BATH, 35 KHZ, 230 V 50/60 HZ, ID DIA. 540 MM, 500 MM HIGH, 38 L, S/S TIMER 1-15 MIN AND CONTINU OUS, DRAIN BALL COCK 1/2 , ULTRASONIC PEAK OUTPUT 1200 W, HF-OUTPUT: 300 WEFF. 1 * 1 items

Supplier: BANDELIN-ELECTRONIC

SONOREX SUPER RK 255 H, ULTRASONIC BATH, 35 KHZ, 230 V~ 50/60 HZ, ID 300X150X150 MM 5,5 L, S/S TIMER 1-15 MIN AND CONTINUOUS, HEA TING 30-80°C (86-176°F), DRAIN BALL COCK 1/4 , ULTRASONIC PEAK OUTPUT 640 W, HF-OUTPUT: 160 WEFF. 1 * 1 items

Supplier: BANDELIN-ELECTRONIC

SONOREX SUPER RK 510 H, ULTRASONIC BATH, 35 KHZ, 230 V~ 50/60 HZ, ID 300X240X150 MM 9,7 L, S/S TIMER 1-15 MIN AND CONTINUOUS, HEA TING 30-80°C (86-176°F), DRAIN BALL COCK 1/2 , ULTRASONIC PEAK OUTPUT 640 W, HF-OUTPUT: 160 WEFF. 1 * 1 items