136900 Results for: "5-Chloro-2-methylpyrimidine-4-carboxylic+acid"

Supplier: Bioss

Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.

Supplier: Cytiva

Amersham™ Protran® membranes are manufactured from 100% pure nitrocellulose to ensure the highest binding capacity possible. They are compatible with a variety of detection methods, including isotopic, chemiluminescent, colorimetric and fluorescent. No methanol pre-wetting step is required, making this the membrane of choice for proteins which prefer aqueous environments. Prior to transfer the membrane is simply wetted with water, and then placed in the transfer buffer. No other pretreatment steps are necessary.

Supplier: ProSci Inc.

AIF Antibody: Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins. A novel gene, the product of which causes chromatin condensation and DNA fragmentation, was recently identified, cloned, and designated apoptosis inducing factor (AIF). Like the critical molecules, cytochrome c and caspase-9, in apoptosis, AIF localizes in mitochondria. AIF translocates to the nucleus when apoptosis is induced and induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. AIF induces chromatin condensation and large scale DNA fragmentation, which are the hallmarks of apoptosis, of the isolated nucleus and the nucleus in live cells by microinjection and apoptosis stimuli. AIF is highly conserved between human and mouse and widely expressed.

Supplier: Antibodies.com

Human alpha smooth muscle Actin ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human alpha smooth muscle Actin in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: Antibodies.com

Human Insulin degrading enzyme/IDE ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human Insulin degrading enzyme/IDE in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: Antibodies.com

Human ZO1 Tight Junction Protein ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human ZO1 Tight Junction Protein in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: Antibodies.com

Monkey beta Nerve Growth Factor ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of monkey beta Nerve Growth Factor in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: Antibodies.com

Human Fc Fragment of IgA Receptor ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human Fc Fragment of IgA Receptor in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: Antibodies.com

Human non-muscle Myosin IIA ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human non-muscle Myosin IIA in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: Antibodies.com

Rat CaMKII beta ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of rat CaMKII beta in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: Antibodies.com

Rat alpha smooth muscle Actin ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of rat alpha smooth muscle Actin in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: Antibodies.com

Porcine beta Nerve Growth Factor ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of porcine beta Nerve Growth Factor in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: Antibodies.com

Rat Angiotensin II Type 2 Receptor ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of rat Angiotensin II Type 2 Receptor in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: Antibodies.com

Human NF-kB p65 ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human NF-kB p65 in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: Ahlstrom-Munksjö

This LeafSaver is ideal for simple collection, transportation and ambient-temperature storage of plants, fungi, insects and parasites.

Supplier: ProSci Inc.

Aquaporin 2 (AQP2) is a hormonally regulated water channel located in the renal collecting duct. Mutations in the AQP2 gene cause hereditary nephrogenic diabetes insipidus in humans (Iolascon et al.,2007). A vasopressin induced cAMP increase results in the phosphorylation of AQP2 at serine-256 and its translocation from the intracellular vesicles to the apical membrane of principal cells (van Balkom et al., 2002). Recently, serine-261 has been identified as a novel phosphorylation site on AQP2 and levels of phosphorylated S261 have been shown to decrease with vasopressin treatment suggesting its involvement in vasopressin-dependent AQP2 trafficking (Hoffert et al., 2007).

Supplier: ProSci Inc.

PDL-1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. PDL-1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PDL-1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts. At least two isoforms of PDL-1 are known to exist; this antibody is specific to the larger isoform. PDL-1 antibody has no cross-reactivity to PDL-2.

Supplier: Thermo Fisher Scientific

Thermo Scientific Pierce Sulfo-LC-SDA (Sulfo-NHS-LC-Diazirine) combines proven NHS-ester and diazirine-based photoreaction chemistries with conjugate amine-containing molecules with nearly any other functional group via long-wave UV-light activation. A 12.5Å spacer arm separates the two photoreactive groups.

Supplier: Thermo Fisher Scientific

Thermo Scientific Pierce Sulfo-SDAD (Sulfo-NHS-SS-Diazirine) combines proven NHS-ester and diazirine-based photoreaction chemistries with conjugate amine-containing molecules with nearly any other functional group via long-wave UV-light activation. A 13.5Å spacer arm containing a cleavable disulfide bond separates the two photoreactive groups.

Supplier: Antibodies.com

Rat ZO1 Tight Junction Protein ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of rat ZO1 Tight Junction Protein in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: Antibodies.com

Rat Angiotensin II Type 1 Receptor ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of rat Angiotensin II Type 1 Receptor in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: Antibodies.com

E. coli Host Cell Proteins ELISA Kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of E. coli Host Cell Proteins in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: Antibodies.com

Mouse Insulin degrading enzyme/IDE ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of mouse Insulin degrading enzyme/IDE in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: BIGNEAT

Chemcap™ Clearview™ ductless fume hoods include Chemcap™ carbon filtration. A range of six standard cabinet sizes with keypad control panel, touch button controls and service due indicator. Includes 18 W fluorescent lamp and PVC base tray which offers excellent chemical resistance and contains spillages.
Cabinets are manufactured from polyester coated steel; transparent panels are acrylic and resistant to corrosion.

Supplier: EPPENDORF

Eppendorf Tubes® 3810X microtubes (1,5 ml) are designed for seamless one-handed operation with an easy-to-open, securely closing tube design. Perfect for sample preparation, centrifugation, and storage, these tubes will effortlessly integrate into workflows for efficient and reliable performance.

Supplier: LABCONCO

Protector premier hoods are suitable for general chemistry applications and also explosion-proof models are available for laboratories with potentially explosive/flammable atmospheres. Hoods are available with a built-in standard fiberglass blower, or an explosion-proof fiberglass blower, or without a blower (remote blower sold separately).

Supplier: ProSci Inc.

Synapsin I plays a key role in synaptic plasticity in brain. This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. In addition to its role in plasticity, the expression of synapsin I is a precise indicator of synapse formation. Thus synapsin I immunocytochemistry provides a valuable tool for the study of synaptogenesis. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation. Serine 9 is the site on synapsin I that is phosphorylated by cAMP-dependent protein kinase and by calcium calmodulin kinase I. Phosphorylation of this site is thought to regulate synaptic vesicle function.

Supplier: Antibodies.com

Human CaMKII delta ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human CaMKII delta in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: Antibodies.com

Human Serum Response Factor SRF ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human Serum Response Factor SRF in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: Antibodies.com

Mouse NF-kB p65 ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of mouse NF-kB p65 in serum, plasma, tissue homogenates, and other biological fluids.