4583 Results for: "4-(4-Fluorobenzyl)piperidine"

Supplier: Enzo Life Sciences

Highly potent and selective serotonin uptake inhibitor

Supplier: Abcam

Potent, selective, reversible AMP-kinase inhibitor (Ki = 109 nM). BMP type I receptor inhibitor. Induce autophagy in cancer cells independent of AMPK inhibition. Promotes cardiomyogenesis in embryonic stem cells. Reduces hepcidin, VCAM-1 and ICAM-1 expression in vivo.

Supplier: Apollo Scientific

Migalastat hydrochloride

Supplier: Apollo Scientific

tert-Butyl-4-(N-methoxy-N-methylcarbamoyl)-1-piperidinecarboxylate 98%

Supplier: Apollo Scientific

4-Chloro-N-cyclopropyl-N-(4-piperidinyl)benzene-sulphonamide 95+%

Supplier: Apollo Scientific

1-[1-(tert-Butoxycarbonyl)-4-piperidinyl]-5-oxo-3-pyrrolidinecarboxylic acid

Supplier: Apollo Scientific

1-(2,3-Dihydro-1-benzofuran-5-ylmethyl)-4-piperidinecarboxylic acid

Supplier: Thermo Fisher Scientific

Repaglinide

Supplier: Abcam

A potent and selective Oxidative Phosphorylation Inhibitor (IC₅₀ <10 nM) with potential antineoplastic activity. IACS-010759 robustly inhibits proliferation and induces apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS, likely owing to a combination of energy depletion and reduced aspartate production that leads to impaired nucleotide biosynthesis.

Supplier: Apollo Scientific

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

Supplier: Molekula

(±)-Pipecolinic acid

Supplier: Apollo Scientific

3-[4-(1,3-Benzoxazol-2-yl)piperidino]propanoic acid

Supplier: Molekula

(S)-(+)-Nipecotic acid

Supplier: Apollo Scientific

4-Aminobutyric acid

Supplier: Apollo Scientific

1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-3-piperidinecarboxylic acid

Supplier: Apollo Scientific

Ethyl-1-(5-chloro-6-oxo-1,6-dihydro-4-pyridazinyl)-4-piperidinecarboxylate

Supplier: Thermo Fisher Scientific

MK-4827 97%

Supplier: Abcam

PD-1/PD-L1 inhibitor 1 blocks the PD-1/PD-L1 interaction with an IC₅₀ of 6 nM in a cell-free HTRF assay.

Supplier: Thermo Fisher Scientific

4-Aminobutyric acid 99+%

Supplier: Abcam

Potent, cell-permeable Janus kinase 3 (JAK3) inhibitor with some JAK1 inhibitory activity as well. Pyrrolo[2,3-d]pyrimidine derivative. Blocks downstream STAT signaling resulting in potent inhibition of inflammatory cytokines with resultant immunosuppressive and anti-inflammatory activity.

Supplier: Enzo Life Sciences

A novel inhibitor of glucosylceramide synthase as well as glucosidase I and II. Inhibits glucosylceramide synthase without ceramide accumulation and cell death. It is a potent inhibitor of human immunodeficiency virus (HIV) replication and syncytium formation in vitro. Restores chloride current in epithelial CF cells.

Supplier: Apollo Scientific

1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-(2-hydroxyethyl)piperdine-4-carboxamide 97%

Supplier: Abcam

Non-selective phosphodiesterase (PDE) inhibitor. Exerts antiplatelet, anti-infla mMatory, antioxidative and antifibrotic effects. Inhibits hydrolysis of cyclic AMP (cAMP) and cGMP (IC₅₀ = 5 and 3 μM, respectively) in vitro.

Supplier: Abcam

Potent, selective SCD1 inhibitor (IC₅₀ values are 4,5 and 26 nM in mouse and human SCD1, respectively). Inhibits saturated, long-chain fatty acyl-CoAs conversion to monounsaturated, long-chain fatty acyl-CoAs (IC₅₀ values are 7,9 and 6,8 nM for heptadecanoic acid and palmitic acid, respectively).

Supplier: Molekula

(R)-(-)-Nipecotic acid

Supplier: Thermo Fisher Scientific

4-Aminobutyric acid 97%

Supplier: Abcam

Highly potent, irreversible Bruton tyrosine kinase (BTK) inhibitor (IC₅₀ = 0,5 nM). Inhibits autophosphorylation of BTK IC₅₀ = 11 nM), and phophorylation of PLCγ (IC₅₀ = 29 nM) and ERK (IC₅₀ = 13 nM). Potently inhbits BLK, BMS, FGR, EGFR and ITK kinases. Blocks B-cell antigen receptor (BCR) activation. Cytotoxic to chronic lymphocytic leukemia (CLL) cells.

Supplier: Thermo Fisher Scientific

Ebastine

Supplier: Thermo Fisher Scientific

Minoxidil

Supplier: Abcam

An inhibitor of the N-linked oligosaccharide processing enzymes α-glucosidase I and II. It inhibits rat testicular enzymes ceramide-glucosyltransferase and beta-glucosidase 2 with IC₅₀ values of 32 and 81 μM respectively. Miglustat is used for the treatment of type 1 Gaucher's disease. It is an inhibitor of HIV replication in vitro. It shows activity against SARS-CoV-2 in vitrowith EC₅₀ values in the micromolar range.