94231 Results for: "4\'-Acetylbiphenyl-4-carboxylic+acid&pageNo=9"

Supplier: ENZO LIFE SCIENCES

Inhibitor of PPARα activation. Inhibits 5-lipoxygenase-activating protein (FLAP) and leukotriene biosynthesis. Binds to FLAP with high affinity and prevents the activation of 5-lipoxygenase. IC50’s for leukotriene biosynthesis: 2.5 nM in intact leukocytes; 1.1 µM in whole blood. Induces apoptosis through the mitochondrial pathway.

Supplier: ENZO LIFE SCIENCES

Potent and selective inhibitor of GSK-3β (IC50=34nM). Stimulates glycogen synthesis in human liver cells and mimics other actions of insulin. Protects primary neurons from death induced by PI-3 kinase pathway inhibition suggesting therapeutic potential in neurodegenerative diseases and stroke. Reduces pulmonary inflammation and fibrosis in a mouse model.

Supplier: ENZO LIFE SCIENCES

Weak histone deacetylase (HDAC) inhibitor. Induces differentiation, growth arrest and apoptosis in a number of cell lines. Protects against cerebral ischemic injury and displays neuroprotective effect in a mouse model of Huntington’s disease. Anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation. Shows chemical chaperone activity.

Supplier: ENZO LIFE SCIENCES

HSP90 inhibitor

Supplier: ENZO LIFE SCIENCES

A potent and selective inhibitor of Cdc25 phosphatase (Ki's for Cdc25A, B and C are 32, 96 and 40 nM respectively). NSC-95397 inhibits the growth of several human tumor cell lines and blocks G2/M cell cycle transition.

Supplier: ENZO LIFE SCIENCES

PKC inhibitor. Has been shown to selectively inhibit several PKC isoenzymes (IC50 = 7nM for PKCα and PKCβ; 6nM for PKCγ; 10nM for PKCδ; 60nM for PKCζ). The compound does not effectively inhibit PKCµ (IC50=20 µM) and therefore can be used to differentiate PKCµ from other isoforms.

Supplier: ENZO LIFE SCIENCES

GPR119 activator.

Supplier: ENZO LIFE SCIENCES

Blocks lipid peroxidation

Supplier: ENZO LIFE SCIENCES

Potent inhibitor of farnesyltransferase in isolated enzyme assays (IC50=55nM) but is inactive in whole cells. Inhibition of farnesyltransferase is selective over geranylgeranyltransferase I and II (IC50=92µM and 34µM respectively).

Supplier: ENZO LIFE SCIENCES

HMG-CoA reductase inhibitor

Supplier: ENZO LIFE SCIENCES

A novel geldanamycin fluorescent probe that may be used in a fluorescence polarization assay for HSP90 inhibitors. May also be used for detection of cell surface HSP90.

Supplier: ENZO LIFE SCIENCES

Inhibitor of a variety of serine/threonine and tyrosine kinases, like protein kinase C (PKC), cyclic AMP-dependent protein kinase (PKA), S6 kinase, Akt (protein kinase B; PKB), epidermal growth factor receptor (EGFR) tyrosine kinase activity and others including KDR, VEGFR, PDGFR, c-kit and other receptor tyrosine kinases. Potently inhibits FLT-3 kinase including mutant forms found in acute myeloid leukemia in vitro and in vivo. Apoptosis inducer. Showed broad antiproliferative activity against various tumor cell lines. Selectively inhibits T lymphocyte production of TNF-α. Upregulates endothelial nitric oxide synthase (eNOS; NOS III). Abrogates tumor angiogenesis in vivo.

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NOS inhibitor

Supplier: Apollo Scientific

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(4-(tert-butoxy)phenyl)butanoic acid 250mg pack 1 * 250 mg

Supplier: Apollo Scientific

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(6-methoxypyridin-3-yl)propanoic acid 1g pack 1 * 1 g

Supplier: Apollo Scientific

3-Nitro-9H-fluoren-2-amine 25mg pack 1 * 25 mg

Supplier: Apollo Scientific

6,8-Dichloro-9H-purin-2-amine 250mg pack 1 * 250 mg

Supplier: Apollo Scientific

4-[2-({[(9h-fluoren-9-yl)methoxy]carbonyl}amino)ethoxy]benzoic acid 100mg pack 1 * 100 mg

Supplier: Apollo Scientific

4-[2-({[(9h-fluoren-9-yl)methoxy]carbonyl}amino)ethoxy]benzoic acid 50mg pack 1 * 50 mg

Supplier: Apollo Scientific

2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(ethyl)amino)-2-methylpropanoic acid 1g pack 1 * 1 g

Supplier: Apollo Scientific

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(thiophen-3-yl)acetic acid 250mg pack 1 * 250 mg

Supplier: Apollo Scientific

4-[2-({[(9h-fluoren-9-yl)methoxy]carbonyl}amino)ethoxy]benzoic acid 2.5g pack 1 * 2,5 g

Supplier: Apollo Scientific

2-[4-({[(9h-fluoren-9-yl)methoxy]carbonyl}amino)piperidin-1-yl]acetic acid 250mg pack 1 * 250 mg

Supplier: Apollo Scientific

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1H-tetrazol-5-yl)propanoic acid 1g pack 1 * 1 g

Supplier: Apollo Scientific

3-(1-{[(9h-fluoren-9-yl)methoxy]carbonyl}piperidin-4-yl)propanoic acid 1g pack 1 * 1 g

Supplier: Apollo Scientific

2-[4-({[(9h-fluoren-9-yl)methoxy]carbonyl}amino)piperidin-1-yl]acetic acid 1g pack 1 * 1 g

Supplier: Apollo Scientific

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-((2,2,10,10-tetramethyl-4,8-dioxo-3,9-dioxa-5,7-diazaundecan-6-ylidene)amino)pen tanoic acid 250mg pack 1 * 250 mg

Supplier: Apollo Scientific

2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-methylpentanoic acid 1g pack 1 * 1 g

Supplier: Apollo Scientific

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-ethoxypropanoic acid 1g pack 1 * 1 g

Supplier: Apollo Scientific

N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-O-ethyl-N-methyl-L-serine 100mg pack 1 * 100 mg