49563 Results for: "3-Methyl-3,8-diazabicyclo[3.2.1]octane+dihydrochloride"

Supplier: Bioss

Pokemon, the POK erythroid myeloid ontogenic factor, not only regulates the expression of many genes, but also plays an important role in cell tumourigenesis. To investigate the molecular mechanism regulating expression of the Pokemon gene in humans, its 5'-upstream region was cloned and analyzed. Transient analysis revealed that the Pokemon promoter is constitutive. Deletion analysis and a DNA decoy assay indicated that the NEG-U and NEG-D elements were involved in negative regulation of the Pokemon promoter, whereas the POS-D element was mainly responsible for its strong activity. Electrophoretic mobility shift assays suggested that the NEG-U, NEG-D and POS-D elements were specifically bound by the nuclear extract from A549 cells in vitro. Mutation analysis demonstrated that cooperation of the NEG-U and NEG-D elements led to negative regulation of the Pokemon promoter. Moreover, the NEG-U and NEG-D elements needed to be an appropriate distance apart in the Pokemon promoter in order to cooperate. Taken together, our results elucidate the mechanism underlying the regulation of Pokemon gene transcription, and also define a novel regulatory sequence that may be used to decrease expression of the Pokemon gene in cancer gene therapy.

Supplier: Rockland Immunochemicals

Anti-MeCP2 pS80 (Rabbit) is suitable for use in Western Blotting and IHC. Anti-MeCP2 pS80 antibodies have been used successfully for IHS on mouse brain sections. Specific conditions for reactivity should be optimized by the end user.

Supplier: Rockland Immunochemicals

Anti-NMDA R2B (Rabbit) antibody is suitable for use in Western Blotting and IHC. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 180 kDa in size corresponding to the NR2B subunit or the NMDA receptor.

Supplier: Dräger

To measure the 'spot concentrations' of chlorine dioxide with an Accuro® pump. Uses include determination of concentration peaks, personal exposure in the inhalation area, detection of leaks in pipelines or gas installations, air analysis in sewers, shafts and confined spaces. The following values are not displayed:

Supplier: Rockland Immunochemicals

Anti-NR2B Antibody is suitable for use in WB, IHC and IP. Expect a band approximately ~166kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Supplier: Rockland Immunochemicals

Anti-NMDA R2A pT1325 Antibody is suitable for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 180 kDa in size corresponding to NMDAR NR2A subunit Protein phosphorylated at Tyr1325.

Supplier: Rockland Immunochemicals

Anti-NMDA R2A Antibody is suitable for use in Western Blotting and IHC. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 180 kDa in size corresponding to the NR2A subuint of the NMDA receptor.

Supplier: Antibodies.com

Mouse monoclonal [S327-95] antibody to NMDAR2A for WB, IHC and ICC/IF with samples derived from human, mouse and rat.

Supplier: Rockland Immunochemicals

Anti-NMDA R2B pT1252 Antibody is suitable for use in Western Blotting and IHC. Expect a band of approximately 180 kDa in size corresponding to NMDAR NR2B subunit Protein phosphorylated at Tyr1252 in the appropriate cell lysate or extract.

Supplier: MP Biomedicals

Menhaden fish oil has been refined to produce a more palatable, clearer oil. It has undergone the winterizing process similar to the alkali refined and bleached oil. The cold test results in a minimum of two hours at 40 °F.

Supplier: Antibodies.com

Rabbit polyclonal antibody to Histone H4 for WB, IHC, IF and ELISA with samples derived from Human, Mouse and Rat.

Supplier: Antibodies.com

Rabbit polyclonal antibody to Histone H4 (acetyl Lys5) for WB, IHC, IF and ELISA with samples derived from Human, Mouse and Rat.

Supplier: Antibodies.com

Rabbit monoclonal [ARC0410] antibody to NMDAR2A for WB and IHC with samples derived from human, mouse and rat.

Supplier: Rockland Immunochemicals

Anti-NMDA R2B Antibody is suitable for use in Western Blotting. Expect a band of approximately 180kDa in size corresponding to the NR2B subunit of the NMDA receptor in appropriate cell lysate or extract. A dilution of 1:1000 is recommended in western blot.

Supplier: Rockland Immunochemicals

Anti-NMDA R2C pS1096 (Rabbit) antibody is suitable for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 140 kDa in size corresponding to the NR2C subunit of the NMDA receptor protein.

Supplier: VWR Chemicals

The level of volatile organic solvents in pharmaceutical raw materials or finished product is defined and monitored in accordance with ICH guidelines. Residual solvents are classified according to their risk assessment classes. A selection of residual solvent standards is now available from Avantor.

Supplier: Bioss

The Ras-related superfamily of guanine nucleotide binding proteins, which includes the R-Ras, Rap, Ral/Rec and Rho/Rab superfamilies exhibit 30-60% homology with Ras p21. Accumulating data suggests an important role for Rab proteins, either in endocytosis or in biosynthetic protein transport. The transport of newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves at each stage the movement of carrier vesicles, a process that appears to involve Rab protein function. The possiblity that Rab proteins might also direct the exocytosis from secretory vesicles to the plasma membrane is supported by the observation that in yeast, the SEC4 protein, which is 40% homologous to Rab proteins, is associated with secretory vesicles. At least eight members of the Rab family have been identified, each of which is found at a particular stage of a membrane transport pathway.

Supplier: Bioss

Comprising nearly 4% of human DNA, chromosome 13 contains around 114 million base pairs and 400 genes. Key tumor suppressor genes on chromosome 13 include the breast cancer susceptibility gene, BRCA2, and the RB1 (retinoblastoma) gene. RB1 encodes a crucial tumor suppressor protein which, when defective, leads to malignant growth in the retina and has been implicated in a variety of other cancers. The gene SLITRK1, which is associated with Tourette syndrome, is on chromosome 13. As with most chromosomes, polysomy of part or all of chromosome 13 is deleterious to development and decreases the odds of survival. Trisomy 13, also known as Patau syndrome, is quite deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections. The LOC728591 gene product has been provisionally designated LOC728591 pending further characterization.

Supplier: Bioss

Comprising nearly 4% of human DNA, chromosome 13 contains around 114 million base pairs and 400 genes. Key tumor suppressor genes on chromosome 13 include the breast cancer susceptibility gene, BRCA2, and the RB1 (retinoblastoma) gene. RB1 encodes a crucial tumor suppressor protein which, when defective, leads to malignant growth in the retina and has been implicated in a variety of other cancers. The gene SLITRK1, which is associated with Tourette syndrome, is on chromosome 13. As with most chromosomes, polysomy of part or all of chromosome 13 is deleterious to development and decreases the odds of survival. Trisomy 13, also known as Patau syndrome, is quite deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections. The LOC728591 gene product has been provisionally designated LOC728591 pending further characterization.

Supplier: Bioss

Comprising nearly 4% of human DNA, chromosome 13 contains around 114 million base pairs and 400 genes. Key tumor suppressor genes on chromosome 13 include the breast cancer susceptibility gene, BRCA2, and the RB1 (retinoblastoma) gene. RB1 encodes a crucial tumor suppressor protein which, when defective, leads to malignant growth in the retina and has been implicated in a variety of other cancers. The gene SLITRK1, which is associated with Tourette syndrome, is on chromosome 13. As with most chromosomes, polysomy of part or all of chromosome 13 is deleterious to development and decreases the odds of survival. Trisomy 13, also known as Patau syndrome, is quite deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections. The LOC728591 gene product has been provisionally designated LOC728591 pending further characterization.

Supplier: EBRO

K-Type surface probe TPN321, up to 300°C, Ø 12mm, L 30mm, angled, 1m silicone cable fixed, SMP 1 * 1 items

Supplier: HAMILTON BONADUZ

PRP-1 polymeric HPLC columns are designed for broad ranging uses, similar to C8 or C18 HPLC materials. They combine the best characteristics of silica-based and polymeric columns resulting in highly inert and long-lasting columns. These columns are ideal for applications that require a high degree of column to column and batch to batch consistency (quality assurance, clinical trials). Unlike C8 or C18 columns, PRP-1 has no stationary phase coating. Since there is no stationary phase to hydrolyse, the column maintains its performance characteristics longer than many C8 or C18 columns.

Supplier: Rockland Immunochemicals

Anti-NMDA R2C pS1244 Antibody is suitable for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 140 kDa in size corresponding to the NMDA receptor phosphorylated at Ser1244.

Supplier: Rockland Immunochemicals

Anti-NMDA R2A Antibody is suitable for use in Western Blotting and IHC. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 180 kDa in size corresponding to the NR2A subuint of the NMDA receptor.

Supplier: Antibodies.com

Rabbit polyclonal antibody to Histone H4 for WB, IHC, IF and ELISA with samples derived from Human, Mouse and Rat.

Supplier: Antibodies.com

Rabbit polyclonal antibody to Histone H4 (acetyl Lys12) for WB, IHC, IF and ELISA with samples derived from Human, Mouse and Rat.

Supplier: GILSON

Designed for performance and comfort, PIPETMAN® L comes in a comprehensive range of models, adapted to your needs in the lab. PIPETMAN L air-displacement pipettes cover a full volume range. Comfortable, precise, accurate, and reliable, use PIPETMAN L pipettes confidently in your applications.

Supplier: FRISTADS KANSAS

Thanks to its durability and high degree of comfort, the PR54 jacket is perfectly suited to workshops and industrial and service enterprises. The material is made from 65% polyester and 35% cotton. The inside is brushed and as a result conveys a pleasantly comfortably cotton feeling. The outside is also resistant to the roughest demands and will not fade even after countless washes.

Supplier: Merck

The Aquastar® range is designed to provide reagents for the determination of water by Karl Fischer titration of a wide range of substrates and by a variety of methodologies. These include reagents for one- or two-component systems; combined coulometric reagents; solvents for oils and fats; reagents and solvents for determination of water in ketones and aldehydes. Calibration standards are also available.

Supplier: Whatman products (Cytiva)

Whatman chromatography papers are widely used across the world, reflecting their purity, high quality and consistency. They are made from specially selected cotton cellulose and rigorously quality controlled to ensure uniformity within the grade.