21448 Results for: "3-Fluoro-5-(trifluoromethoxy)-DL-phenylalanine&pageNo=11"

Supplier: Bioss

IGSF11 is also known as BTIGSF (brain and testis-specific immunoglobulin superfamily protein) or VSIG3 (V-set and immunoglobulin domain-containing protein 3) and is a 431 amino acid protein that is expressed as three isoforms. IGSF11 is highly expressed in testis and ovary and is also expressed in brain, kidney and skeletal muscle, localized to the cellular membrane as a single-pass membrane protein. IGSF11 is an immunoglobulin with V-type and C2-type domains that function in molecular recognition. When IGSF11 is in the trans position, it plays an important role in cell-cell adhesion via both homophilic and heterophilic interactions with other molecules. These cell–cell interactions are also thought to be important for neuronal cell interactions, such as neuron–neuron or neuron–glia interactions, which are important for the development and function of the central nervous system. In addition, IGSF11 might also be involved interactions between Sertoli cells and spermatocytes, which are important associations during spermatogenesis. The IGSF11 gene is commonly upregulated in gastric cancer and IGSF11 is highly expressed in many types of human tumors, indicating that it may be useful as a target for immunotherapy.

Supplier: Bioss

IGSF11 is also known as BTIGSF (brain and testis-specific immunoglobulin superfamily protein) or VSIG3 (V-set and immunoglobulin domain-containing protein 3) and is a 431 amino acid protein that is expressed as three isoforms. IGSF11 is highly expressed in testis and ovary and is also expressed in brain, kidney and skeletal muscle, localized to the cellular membrane as a single-pass membrane protein. IGSF11 is an immunoglobulin with V-type and C2-type domains that function in molecular recognition. When IGSF11 is in the trans position, it plays an important role in cell-cell adhesion via both homophilic and heterophilic interactions with other molecules. These cell–cell interactions are also thought to be important for neuronal cell interactions, such as neuron–neuron or neuron–glia interactions, which are important for the development and function of the central nervous system. In addition, IGSF11 might also be involved interactions between Sertoli cells and spermatocytes, which are important associations during spermatogenesis. The IGSF11 gene is commonly upregulated in gastric cancer and IGSF11 is highly expressed in many types of human tumors, indicating that it may be useful as a target for immunotherapy.

Supplier: Bioss

Comprising more than ten subunits, the anaphase-promoting complex (APC) acts in a cell-cycle dependent manner to promote the separation of sister chromatids during the transition between metaphase and anaphase in mitosis. APC, or cyclosome, accomplishes this progression through the ubiquitination of mitotic cyclins and other regulatory proteins that are targeted for destruction during cell division. APC is phosphorylated, and thus activated, by protein kinases Cdk1/cyclin B and polo-like kinase (Plk). APC is under tight control by a number of regulatory factors, including CDC20, CDH1 and MAD2. Specifically, CDC20 and CDH1 directly bind to APC and activates APC’s cyclin-ubiquitination activity. In contrast, MAD2 inhibits APC by forming a ternary complex with CDC20 and APC; thus preventing APC activation. APC11 is a RING-H2 finger protein that allows for the synthesis of multiubiquitin chains in the presence of Ubiquitin carrier protein 4 (Ubc4) and ubiquitin conjugating enzyme (E2). In addition, a heterodimeric complex of either Ubc4 or UbcH10 with APC11 and APC2 catalyzes the ubiquitination of human securin and cyclin B1.

Supplier: asecos

Safe active and passive storage of lithium-ion batteries.

Supplier: Thermo Scientific

Thermo Scientific™ TDE Series ‒40 °C ultra-low temperature freezers, powered by H-drive, feature three upright models, maximizing storage capacity from 40000 up to 60000 2 ml vials. The TDE Series is a sustainable and reliable solution with ultimate sample security and operational savings for every laboratory.

Supplier: BIOTIX

This new generation of tips form an excellent seal on both single- and multi-channel pipettes guaranteeing total recovery of the sample whilst protecting the technician against the risks of repetitive strain injury. The tips are manufactured with proprietary technologies for increased pipetting accuracy and precision.

Supplier: Bioss

The Drosophila hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch Signalling pathway and control segmentation and neural development during embryogenesis. The mammalian homologues of Drosophila hairy and Enhancer of split are the HES gene family members, HES1-6, which also encode bHLH transcriptional repressors that regulate myogenesis and neurogenesis. The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.

Supplier: Bioss

IGSF11 is also known as BTIGSF (brain and testis-specific immunoglobulin superfamily protein) or VSIG3 (V-set and immunoglobulin domain-containing protein 3) and is a 431 amino acid protein that is expressed as three isoforms. IGSF11 is highly expressed in testis and ovary and is also expressed in brain, kidney and skeletal muscle, localized to the cellular membrane as a single-pass membrane protein. IGSF11 is an immunoglobulin with V-type and C2-type domains that function in molecular recognition. When IGSF11 is in the trans position, it plays an important role in cell-cell adhesion via both homophilic and heterophilic interactions with other molecules. These cell–cell interactions are also thought to be important for neuronal cell interactions, such as neuron–neuron or neuron–glia interactions, which are important for the development and function of the central nervous system. In addition, IGSF11 might also be involved interactions between Sertoli cells and spermatocytes, which are important associations during spermatogenesis. The IGSF11 gene is commonly upregulated in gastric cancer and IGSF11 is highly expressed in many types of human tumors, indicating that it may be useful as a target for immunotherapy.

Supplier: asecos

Fireproof safety cabinets, classified type 90 (fire resistant up to 90 minutes), safe, durable, robust and convenient with transport base and bicoloured cabinet design. The PEGASUS line is nearly identical to the CLASSIC line, but with integrated AGT (one handed operation for double door cabinets) and integrated TSA (door open arrest system and automatic door closing).

Supplier: Bioss

The Drosophila hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch Signalling pathway and control segmentation and neural development during embryogenesis. The mammalian homologues of Drosophila hairy and Enhancer of split are the HES gene family members, HES1-6, which also encode bHLH transcriptional repressors that regulate myogenesis and neurogenesis. The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.

Supplier: Sartorius Balances

The Cubis® II range has a modular design that to allows the customer to choose the components that suit the application area that is of interest. For the customer, this configurable concept delivers quality weighing, together with a high degree of flexibility, without having to invest in expensive equipment that has features that may never be required.

Supplier: Bioss

IGSF11 is also known as BTIGSF (brain and testis-specific immunoglobulin superfamily protein) or VSIG3 (V-set and immunoglobulin domain-containing protein 3) and is a 431 amino acid protein that is expressed as three isoforms. IGSF11 is highly expressed in testis and ovary and is also expressed in brain, kidney and skeletal muscle, localized to the cellular membrane as a single-pass membrane protein. IGSF11 is an immunoglobulin with V-type and C2-type domains that function in molecular recognition. When IGSF11 is in the trans position, it plays an important role in cell-cell adhesion via both homophilic and heterophilic interactions with other molecules. These cell–cell interactions are also thought to be important for neuronal cell interactions, such as neuron–neuron or neuron–glia interactions, which are important for the development and function of the central nervous system. In addition, IGSF11 might also be involved interactions between Sertoli cells and spermatocytes, which are important associations during spermatogenesis. The IGSF11 gene is commonly upregulated in gastric cancer and IGSF11 is highly expressed in many types of human tumors, indicating that it may be useful as a target for immunotherapy.

Supplier: Avantor Fluid Handling

Versatile gear pump systems for high-accuracy fluid delivery - with an intuitive touch-screen interface.

Supplier: Merck

TLC plates, unmodified silica gel 60
This range of plates uses Merck silica gel 60 with a unique polymeric binder that results in a uniform, hard surface that will not easily crack or blister. The smooth, extremely dense plate coating ensures narrow bands and maximum separation efficiency with the lowest background noise. Layer thickness 200 μm and, particle size of 10 to 12 µm. Flexible aluminium plates that can easily be cut to match individual separation requirements. Two inorganic fluorescent indicators for UV detection of colourless substances. Samples which absorb shortwave UV at 254 nm are detected due to fluorescence quenching.

Supplier: VWR Collection

VWR® has expanded the VWR® carboy features and benefits by offering the Versatile Cap, Versatile Barb and state-of-the-art Spigot technology. These three components complement a wide array of applications supported by the VWR® Carboy. The leakproof cap insert with replaceable gasket enable users to quickly change the top connector of each carboy to match the application needs. Versatile Cap is stackable and is offered in both 83 mm (compatible with most industry carboys) and a 120 mm extra wide-mouth version that fits exclusively on VWR® 20 L and 40 L extra wide mouth carboys. To see homogenisation of solutions, closed adapter inserts with a clear window are available. Quick connect options are also a part of the many capabilities of this Versatile Cap technology. This includes quick-connect port combinations of two, three, and four. For bottom tubulation, Versatile Barb is used to replace the spigot and support flexibility in drainage, connection to a pump or automated equipment, or connection to a filling bell. Sanitary fitting connector is also available in order to enable the carboy to be used as a supply reservoir to a larger system.

Supplier: Rubbermaid Commercial Products

Transform the Slim Jim® Vented container in combination with the dollies into a mobile station or with the various lid options into a small recycling station.

Supplier: VWR Collection

Stainless steel circulating baths with choice of Advanced Programmable or Advanced Digital temperature controller. Both are easy to navigate with large, intuitive displays and multiple communication options including USB-A and B, RS232/485, Ethernet and external temperature probe. The reservoir drain can be accessed by removing the front panel. All models feature user-adjustable high temperature safety cut-off points as well as over-temperature protection. The DuraTop™ surface is cool to the touch even when operating at high temperatures.

Supplier: Portwest

The DX4 holster trouser is ergonomically designed and uses the targeted placement of dynamic 4X stretch fabrics to give maximum range of movement when working. The trouser features a high-rise back waistband with side elastication, ensuring protection in all working positions.

Supplier: Portwest

A highly innovative and functional jacket that provides seven wearer combinations. This extremely versatile jacket is highly adaptable to all weather conditions and is certified to the highest in waterproof and breathable standards.

Supplier: EPPENDORF

Unleash the power of precision in DNA research with Eppendorf® DNA LoBind® tubes. Engineered with proprietary LoBind® technology, these microcentrifuge tubes redefine sample handling, minimising the risk of loss and maximising DNA recovery. Ideal for low-concentration applications, including PCR, qPCR, and DNA sequencing, these tubes ensure accuracy, purity, and optimal yields.

Supplier: EPPENDORF

Eppendorf's twin.tec® 96-well, 150 µl PCR Plates feature a polycarbonate frame and thin-walled polypropylene wells ensuring optimal heat transfer and high rigidity. The SafeCode variants enhance sample identification, while the BioBased options, manufactured using renewable resources, provide an eco-friendly alternative without compromising performance.

Supplier: Cole Parmer

Compact general purpose hotplate stirrers designed for safety and performance. The hotplate has an innovative LED temperature indicator scale and can also be used in conjunction with the SCT1 digital contact thermometer to accurately control sample temperature. Powerful magnets and motor give stirring speeds up to 2000 min⁻¹ and unit is capable of mixing large volumes (up to 15 litres*). Both models have an integral fitting for a retort rod.

Supplier: Merck

Fast method development of complex samples across the pH range from 1,5 to 10,5 with different mobile phases and temperature conditions.
Purospher® STAR RP-18 endcapped HPLC columns are designed for universal use. Basic, neutral and metal-chelating compounds can easily be separated with simple mobile phases – naturally without peak tailing. Thanks to its outstanding performance and stability, Purospher® STAR RP-18 endcapped offers maximum flexibility in method development. Robust methods can be developed over the entire pH range from 1,5 to 10,5. High pH-stability allows the separation of strongly basic compounds with alkaline eluents. The combination of high purity silica, best all-round retention characteristics, outstanding pH stability up to pH 10,5, and suitability for up to 100% aqueous mobile phases, make Purospher® STAR RP-18 endcapped an all-round top performance column, almost universal in its range of applications.

Supplier: FRISTADS KANSAS

These overalls with elasticated braces are made of different fabrics. The water-repellent fluorescent material in manufactured from 80% polyester and 20% cotton. The other parts are made of 65% polyester and 35% cotton which is slightly brushed on reverse. Reinforcements are made of 100% polyamide.

Supplier: MEMMERT

Sets eco standards for cultivation below room temperature: Unmatched energy efficiency, excellent heat-up, cool-down and recovery times.

Supplier: Portwest

The DX4 work trouser is ergonomically designed and uses the targeted placement of dynamic 4X stretch fabrics to give maximum range of movement when working. Triple stitching throughout for maximum durability.

Supplier: Ahlstrom-Munksjö

Ahlstrom-Munksjö’s qualitative grades of filter paper are recommended for use in analytical methods which determine or identify particulate constituents of a mixture irrespective of the amount present. Qualitative filter papers are often used in routine separation work that still requires high purity and consistent performance. These filter papers covers a wide range of laboratory applications, as liquids clarification, qualitative analytical separations for precipitates and buffers filtration, and are also used for soil analysis and in food and beverage testing. Wet-strengthened grades contain a reinforcement agent that increases their resistance to rupture when wet, such as in vacuum filtration, and their resistance when filtering acidic solutions. High Purity hardened filter papers grades 1288 to 1291 are also produced from cellulose with an alpha content of nearly 100% resulting in an ash content of <0,1%.

Supplier: EPPENDORF

Eppendorf epT.I.P.S.® Racks feature high-precision pipette tips in 'Eppendorf Quality', 'PCR clean', 'Biopur®', and 'Sterile' purity grades. All tips are supplied in disposible racks designed for optimal organisation and user convenience in demanding laboratory environments.

Supplier: EPPENDORF

Eppendorf epT.I.P.S.® Bulk packs offer a practical, high-volume solution with 'Eppendorf Quality' pipette tips, ensuring precise and reliable measurements for various lab applications, packaged economically for high-throughput settings.

Supplier: SIOEN

This water- and windproof jacket is made of anti-static Siopor FR AST fabric: 100% polyester fabric with 100% FR PU coating + AST. It features a fixed flame-retardant cotton lining with one pocket.