21446 Results for: "3-Fluoro-5-(trifluoromethoxy)-DL-phenylalanine&pageNo=11"

Supplier: Portwest

The Vision softshell is characterised by its modern, fresh design and contemporary stylish fit. The high quality 3-layer breathable, water resistant and windproof fabric along with multiple practical features ensure this is a must-have solution for a range of working professionals.

Supplier: SIOEN

This waterproof and windproof jacket is made of Siopor® Extra fabric consisting of 100% PU laminated polyester fabric (cotton touch). The fabric is water repellent on the outside and moisture attracting on the inside. With fixed mesh lining in body and polyamide lining in sleeves.

Supplier: Portwest

Designed for working in hazardous conditions both off-shore or on-site, this jacket combines style with performance. The special blend of FR polyester in the fabric provides unbeatable durability in the toughest conditions.

Supplier: FRISTADS KANSAS

Thanks to its durability and high degree of comfort, the PR54 jacket is perfectly suited to workshops and industrial and service enterprises. The material is made from 65% polyester and 35% cotton. The inside is brushed and as a result conveys a pleasantly comfortably cotton feeling. The outside is also resistant to the roughest demands and will not fade even after countless washes.

Supplier: EPPENDORF

This centrifuge features a superior capacity of up to 4×1000 ml which makes it the ideal instrument for high-throughput and large volume applications. It has a powerful refrigeration system with advanced temperature management to keep samples safe.

Supplier: biotechrabbit

The Rapid Translation System (RTS) is a scalable in vitro protein expression platform that produces large amounts of protein for characterisation studies, functional assays, or structural analysis. RTS enables both transcription and translation utilising High-Yield (HY) and continuous-exchange, cell-free (CECF) technologies, with systems based on bacterial (E. coli) or eukaryotic (wheat germ) cell lysates. RTS offers the advantages of a cell-free protein expression system, whilst eliminating the need for laborious up and downstream steps typically associated with cell-based expression systems.

Supplier: tempmate

Ultra robust mini logger, the size of a button cell, for recording temperature and humidity measurements with up to fiive years recording duration.

Supplier: Bioss

E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.

Supplier: MOLECULAR DEVICES

FlexStation® 3 Benchtop Multi-Mode Microplate Reader combines SpectraMax® M5e Multi-Mode Microplate Reader performance with an integrated 8- or 16-channel pipettor into one compact benchtop reader. The FlexStation 3 Microplate Reader high-efficiency monochromator optics are tunable for absorbance, fluorescence intensity, fluorescence polarisation, and time-resolved fluorescence assays. It also has a dedicated photomultiplier tube for luminescence assays.

Supplier: Bioss

Ankyrin is a membrane protein that mediates the attachment of the erythrocyte membrane skeleton to the plasma membrane and interacts with CD44 and inositol triphosphate. It contains three functional domains: a conserved N-terminal ankyrin repeat domain (ARD(consisting of 22–24 tandem repeats of 33 amino acids), a spectrin binding domain and a variably sized C-terminal regulatory domain. The ankyrin repeat is a 33-residue motif in proteins consisting of two alpha helices separated by loops. It has been studied using multiple sequence alignment to determine which conserved amino acid residues are critical for folding and stability. Ankyrin-repeat proteins have been associated with a number of human diseases; most notably, the cell cycle inhibitor p16 is associated with cancer and the Notch protein is a key component of cell signaling pathways whose intracellular repeat domain is disrupted in mutations that give rise to the neurological disorder known as CADASIL.

Supplier: Bioss

E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.

Supplier: Bioss

Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf122 gene product has been provisionally designated C1orf122 pending further characterization.

Supplier: Bioss

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq]

Supplier: Bioss

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq]

Supplier: Bioss

Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf192 gene product has been provisionally designated C1orf192 pending further characterization.

Supplier: Bioss

C1orf43, also known as Hepatitis C virus NS5A-transactivated protein 4 and Protein NICE-3, is a 253 amino acid single-pass membrane protein. There are five isoforms of C1orf43 that are produced as a result of alternative splicing events. The gene encoding C1orf43 maps to human chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1.

Supplier: Bioss

C1orf43, also known as Hepatitis C virus NS5A-transactivated protein 4 and Protein NICE-3, is a 253 amino acid single-pass membrane protein. There are five isoforms of C1orf43 that are produced as a result of alternative splicing events. The gene encoding C1orf43 maps to human chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1.

Supplier: Sartorius

High quality pipettes with new, innovative design and technology, combining safety, ergonomics, efficiency in pipetting, with easy calibration and maintenance. They include built-in replaceable tip cone filters, which prevent pipette contamination and damage.

Supplier: ProSci Inc.

CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumour necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodelling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerisation and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signallling cascades, including the NFκB, mitogen-activated protein kinases (MAPK), activating protein 1 (AP-1), and nuclear factor of activated T cells (NFATc1), resulting in the formation of multinucleated bone-resorbing osteoclasts. RANKL is widely expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoblast, mammary gland epithelial cells, prostate and pancreas.

Supplier: Thermo Fisher Scientific

The RT2 is alow-profile digital display hotplatestirrer, equipped with PT100 sensor for precise temperature measurements for sensitive experimental procedures with built-in temperature shut-off to heat samples safely and accurately. The aluminium top provides excellent temperature uniformity while the thin ceramic coating provides excellent corrosion resistance and a white surface for optimal sample viewing. The unit features a keypad lock, hot top warning indicator and has two threaded holes to accommodate support rods.

Supplier: Whatman products (Cytiva)

The Whatman Mini-UniPrep Syringeless Filters combine four products into one syringeless filter solution for efficient chromatography sample preparation for a broad range of applications. They are built for fast and easy high performance liquid chromatography/ultra high performance liquid chromatography sample preparation and analysis.

Supplier: Corning

Filtered, maxymum recovery, and sterile pipette tips in a truly sustainable packaging format that reduces plastic by 70% per case.

Supplier: Heidolph Instruments GmbH & Co.KG

Converts a magnetic stirrer into a multiple experiment workstation, improve the productivity of your laboratory; use a single stirring hotplate to do multiple experiments. Perfect for simple heating/stirring experiments or more complex applications such as synthesis, concentrations, extractions and distillations. Accepts a wide range of standard laboratory glassware including vials, test tubes, beakers and round bottom flasks, a range of inserts are available for small vials up to 250 ml round bottom flasks.

Supplier: Thermo Fisher Scientific

These devices can be used for a wide range of applications including low molecular-weight contaminant removal, buffer exchange, desalting, equilibrium dialysis, and concentration. The cassette membrane is composed of low-binding regenerated cellulose and features a hermetically sealed sample chamber to maintain the highest possible sample retention. This type of membrane is compatible with a number of common chemicals and buffers. The colour-coded transparent frames of the Slide-A-Lyzer® cassette allow instant recognition of the MWCO of the membrane and make viewing the needle easier during sample injection.

Supplier: SIOEN

These water- and wind-proof highly breathable bib & brace overalls are made of 100% polyester fabric with 100% FR PU coating + AST. They also feature a fixed flame retardant cotton lining.

Supplier: SIOEN

Water- and windproof jacket made from highly breathable Siopor® Regular consisting of 100% polyester fabric (plain weave) with 100% PU coating, with fixed mesh lining in body and fixed polyamide lining in sleeves.

Supplier: Brand

The Transferpette® S air displacement pipette allows you to work efficiently and ergonomically with both small and large volumes. Due to its perfect ergonomics, the Transferpette® S provides a comfortable grip in any hand position, whether you are right- or left-handed, or have big or small hands.

Supplier: Portwest

Constructed from breathable 35+ UPF rated cotton fabric which blocks 97% of UV rays combined with premium HiVisTex Pro tape, this comfort fit polo shirt offers excellent comfort and movement. It features a loop at the placket ideal for attaching glasses or pens.

Supplier: Portwest

Portwest continues to push the boundaries in sustainable workwear with the introduction of the WX3 Eco stretch holster trousers. Designed with an active fit, this trouser uses premium recycled polyester with added stretch to give maximum range of movement when working.

Supplier: GILSON

PIPETMAN®, recognized as the pipetting standard for its reliability and proven durability, is a fully adjustable, air-displacement pipette that uses disposable tips. PIPETMAN combines legendary accuracy, precision, and durability with easy pipetting and handling. The pipettes come in a large range of volumes with reduced pipetting forces for hours of comfortable pipetting.