23247 Results for: "3,5-Bis(trifluoromethyl)-\u03B1-methylbenzyl+bromide&pageNo=13"

Supplier: Heidolph Instruments GmbH & Co.KG

Converts a magnetic stirrer into a multiple experiment workstation, improve the productivity of your laboratory; use a single stirring hotplate to do multiple experiments. Perfect for simple heating/stirring experiments or more complex applications such as synthesis, concentrations, extractions and distillations. Accepts a wide range of standard laboratory glassware including vials, test tubes, beakers and round bottom flasks, a range of inserts are available for small vials up to 250 ml round bottom flasks.

Supplier: Thermo Fisher Scientific

These devices can be used for a wide range of applications including low molecular-weight contaminant removal, buffer exchange, desalting, equilibrium dialysis, and concentration. The cassette membrane is composed of low-binding regenerated cellulose and features a hermetically sealed sample chamber to maintain the highest possible sample retention. This type of membrane is compatible with a number of common chemicals and buffers. The colour-coded transparent frames of the Slide-A-Lyzer® cassette allow instant recognition of the MWCO of the membrane and make viewing the needle easier during sample injection.

Supplier: Brand

The Transferpette® S air displacement pipette allows you to work efficiently and ergonomically with both small and large volumes. Due to its perfect ergonomics, the Transferpette® S provides a comfortable grip in any hand position, whether you are right- or left-handed, or have big or small hands.

Supplier: GILSON

PIPETMAN®, recognized as the pipetting standard for its reliability and proven durability, is a fully adjustable, air-displacement pipette that uses disposable tips. PIPETMAN combines legendary accuracy, precision, and durability with easy pipetting and handling. The pipettes come in a large range of volumes with reduced pipetting forces for hours of comfortable pipetting.

Supplier: Portwest

High visibility polo shirt is more comfortable and longer lasting than leading competitors. Ideal for warmer working conditions.

Supplier: Bioss

C17orf57 is a 973 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.

Supplier: Bioss

C17orf57 is a 973 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.

Supplier: Bioss

C17orf57 is a 973 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.

Supplier: Bioss

C17orf57 is a 973 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.

Supplier: Bioss

C17orf57 is a 973 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.

Supplier: HAMILTON BONADUZ

The 700 series syringe is the original hand-fitted Hamilton syringe. This series of syringes is ideal for dispensing volumes from 0,5 to 500 µl. The stainless steel plunger is manufactured to fit the glass barrel with a tolerance smaller than 100 millionths of an inch, resulting in unsurpassed syringe life. Each syringe is manufactured to achieve the highest level of accuracy and precision possible.

Supplier: Priorclave

Compact 40 benchtop and Compact 60 floor standing or benchtop autoclaves for the low volume user, with flexible operation usually only available in larger autoclave units. This flexibility is delivered by the TACTROL™ microprocessor control system, specially developed for laboratory autoclaves, with programming ranging from simple cycles to fully featured multi-program operation with logged records. All Priorclaves come complete with Biomaster antimicrobial coating, helping improved laboratory hygiene; it is effective against all bacteria and fungi including MRSA and therefore helps minimise the risk of cross contamination.

Supplier: ProSci Inc.

Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins.Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins (Ikehara et al., 1999 [PubMed 10536037]; Sewell et al., 2006 [PubMed 16319059]).

Supplier: Cytiva

Amersham™ Protran® membranes are manufactured from 100% pure nitrocellulose to ensure the highest binding capacity possible. They are compatible with a variety of detection methods, including isotopic, chemiluminescent, colorimetric and fluorescent. No methanol pre-wetting step is required, making this the membrane of choice for proteins which prefer aqueous environments. Prior to transfer the membrane is simply wetted with water, and then placed in the transfer buffer. No other pretreatment steps are necessary.

Supplier: FRISTADS KANSAS

Craftsman trousers in strong and light weight ripstop material, with ventilation panels at back and behind knees for increased comfort when working in warm environments.

Supplier: Portwest

Portwest WX3 contemporary workwear is designed to the highest standards and offer a solution for everyday activity and working environments. Constructed with cutting edge fabrics giving superior abrasion resistance and exceptional all-day comfort. The WX3 holster trousers are made from durable poly-cotton canvas fabric and includes triple stitched seams and stretch panelling providing excellent comfort and flexibility.

Supplier: Sartorius Balances

Cubis® II MCA semi-micro balances with advanced user interface offer readability of 10 µg and a maximum weighing capacity up to 220 g. Used for weighing small sample amounts down to the µg-range.

Supplier: Portwest

These fully waterproof anti-static bomber jackets provide multi-norm protection in hazardous conditions. These are designed with chemical resistance and a detachable hood.

Supplier: VELP SCIENTIFIC

DK digesters are traditional digesters, consisting of an aluminium heating block that offers excellent thermal homogeneity, heating up to 450 °C, providing accuracy and minimum energy consumption. DK Series Digesters are suitable for Kjeldahl digestion applications and selected models can be combined with accessories to perform COD and metal determination applications.

Supplier: ProSci Inc.

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.

Supplier: SCIENTIFIC INDUSTRIES ELMIS

Designed to provide rotating, rocking and 3-D orbital shaking in one compact, durable unit for complete and even soaking of membrane-based blot assays/washings. Accommodates up to two 153×153 mm plastic bags per side, a 305×305 mm non-slip metal rocker tray for conventional rocker/shaker operations, or up to four metal clip plates per side to accommodate similar or different tube sizes for various mixing motions. Expansion kits are available for increased capacity, and different containers. The platform is easy to clean or decontaminate.

Supplier: ProSci Inc.

Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. SLC13A3 represents the high-affinity form.Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet.

Supplier: ProSci Inc.

Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. SLC13A3 represents the high-affinity form.Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet.

Supplier: Portwest

Portwest WX3 contemporary workwear is designed to the highest standards and offer a solution for everyday activity and working environments. Constructed with cutting edge fabrics giving superior abrasion resistance and exceptional all-day comfort. The WX3 work trousers are made from durable poly-cotton canvas fabric and includes triple stitched seams and stretch panelling providing excellent comfort and flexibility.

Supplier: LABCONCO

The FreeZone® bulk and stoppering tray dryers have a stainless steel interior and epoxy coated, stainless steel exterior. Units include three probes for monitoring sample and shelf temperature. Microprocessor controlled temperature programming from −40 to +40 °C during ramping and holding in stoppering tray dryers, whereas in bulk dryers a microprocessor maintains the system temperature within 3 °C of the set point (maximum 60 °C). Units have an LCD display and audible/visual alarm indication for temperature and vacuum changes.

Supplier: NEUBERT VOLUME GLASSWAERE

TEST TUBE 13X100 WITH RIM QUARTZ 1 * 1 items

Supplier: LABCONCO

CentriVap® vacuum concentrators are available in a range of configurations. The CentriVap® DNA model is supplied with a built-in 34 litres/min diaphragm pump, two 177 ml glass traps and a DNA rotor (60×1,5/2,0 and 72×0,5 ml). Model with glass lid is recommended for evaporation of solvents that are not compatible with acrylic (acetone, acetonitrile, ethanol, DMSO, etc.). The acid resistant model is recommended for corrosive solvents (TFA, acetic acid, etc.).

Supplier: Boster Bio

The breakpoint cluster region protein (BCR) is a protein that in humans is encoded by the BCR gene. A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

Supplier: TOSOH BIOSCIENCE

SkillPak 1 and 5 ml columns are designed for fast method development, resin screening or sample concentration. Pre-packed with TOYOPEARL®, TSKgel® or Ca++Pure-HA™ process chromatography media, these columns offer superior separation of biomelocules, such as monoclonal antibodies, proteins and oligonucleotides. SkillPak 50 and 200 ml pre-packed columns are the best solution for seamless scale up of methods developed on SkillPak 1 and 5.

Supplier: ProSci Inc.

Noxa Antibody: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A new p53 target gene, Noxa, was recently identified, which encodes a protein belonging to the subfamily of BH3-only proapoptic proteins. Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins. X-ray irradiation increased p53-dependent Noxa mRNA and protein levels. Noxa, when ectopically expressed, interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9. Noxa, like PUMA, localized to mitochondria and induces apoptosis in response to p53. Noxa and PUMA may represent direct mediators of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa was found in the impaired tumor development.