145730 Results for: "2-Methylpyrazine&pageNo=10&view=easy"

Supplier: Bioss

Composed of more than ten subunits, the anaphase-promoting complex (APC) acts in a cell-cycle dependent manner to promote the separation of sister chromatids during the transition between metaphase and anaphase in mitosis. APC, or cyclosome, accomplishes this progression through the ubiquitination of mitotic cyclins and other regulatory proteins that are targeted for destruction during cell division. APC is phosphorylated, and thus activated, by protein kinases Cdk1/cyclin B and polo-like kinase (Plk). APC is under tight control by a number of regulatory factors, including CDC20, CDH1 and MAD2. Specifically, CDC20 and CDH1 directly bind to and activate the cyclin-ubiquitination activity of APCs. In contrast, MAD2 inhibits APC by forming a ternary complex with CDC20 and APC, thus preventing APC activation. APC10 contains a Doc1 homology domain, which is a beta-sandwich structure common to many other putative E3 ubiquitin ligases. APC10 binds to core APC subunits throughout the cell cycle. Specifically, APC10 binds to the C-terminus of CDC27/APC3. During mitosis, APC10 is localized in centrosomes and mitotic spindles. APC10 also localizes to kinetochores from prophase to anaphase, and to the midbody in telophase and cytokinesis.

Supplier: Sartorius Balances

The Cubis® II laboratory balances are modular, providing choice between applications and configurations that best suit the users' needs. These balances can be configured at the level of display, draftshields, software applications and hardware functions. The Cubis® II range of high-capacity micro balances with a maximum load between 32 and 111 g and a readability between 0,001 mg and 0,002 mg provide the ideal choice for a broad range of applications.

Supplier: Bioss

Composed of more than ten subunits, the anaphase-promoting complex (APC) acts in a cell-cycle dependent manner to promote the separation of sister chromatids during the transition between metaphase and anaphase in mitosis. APC, or cyclosome, accomplishes this progression through the ubiquitination of mitotic cyclins and other regulatory proteins that are targeted for destruction during cell division. APC is phosphorylated, and thus activated, by protein kinases Cdk1/cyclin B and polo-like kinase (Plk). APC is under tight control by a number of regulatory factors, including CDC20, CDH1 and MAD2. Specifically, CDC20 and CDH1 directly bind to and activate the cyclin-ubiquitination activity of APCs. In contrast, MAD2 inhibits APC by forming a ternary complex with CDC20 and APC, thus preventing APC activation. APC10 contains a Doc1 homology domain, which is a beta-sandwich structure common to many other putative E3 ubiquitin ligases. APC10 binds to core APC subunits throughout the cell cycle. Specifically, APC10 binds to the C-terminus of CDC27/APC3. During mitosis, APC10 is localized in centrosomes and mitotic spindles. APC10 also localizes to kinetochores from prophase to anaphase, and to the midbody in telophase and cytokinesis.

Supplier: Testo

The testo 865s thermal imager offers professional technology and concentrates on functions which are needed in a contractor's daily work. The user-friendly thermal imager, optimized for fast and efficient work. With the testo ScaleAssist functions ensuring optimum setting of the thermal image scale for building thermography and the IFOV warner making sure to avoid measurement errors, always generate the perfect infrared image. This combines all the important properties required for high-quality thermographic measurement – it is accurate, robust, fast and reliable. The case supplied with the thermal imager means it can be conveniently transported, so it is always there for you when needed.

Supplier: Biosensis

BDNF belongs to the neurotrophin family and promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. It is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. Microglia release BDNF that may contribute to neuroinflammation and neuropathic pain. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. SUBCELLULAR LOCATION: Secreted protein. POst translation modification: Converted into mature BDNF by plasmin (PLG). SIMILARITY: Belongs to the NGF-beta family.

Supplier: Bioss

The LIM-only (LMO) proteins, LMO1 and LMO2, are nuclear factors that are characterised by a conserved LIM domain. The LIM domain consists of a cysteine-rich zinc-binding motif that is present in a variety of transcription factors, including the LIM homeobox (LHX) proteins expressed in the central nervous system and involved in cell differentiation. LMO1 and LMO2 are expressed in the adult CNS in a cell type-specific manner, where they are differentially regulated by neuronal activity and are involved in regulating the cellular differentiated phenotype of neurons. LMO2 lacks a specific DNA-binding homeobox domain but rather assembles into transcriptional regulatory complexes to mediate gene expression by interacting with the widely expressed nuclear LIM interactor (NLI). NLI, known also as CLIM-1, and the related protein CLIM-2, facilitate the formation of heteromeric LIM complexes and also enhance the nuclear retention of LIM proteins. LMO2 and the related protein LMO4 are expressed in thymic precursor cells. LMO4 is also expressed in mature T cells, cranial neural crest cells, somite, dorsal limb bud mesenchyme, motor neurons, and Schwann cell progenitors.

Supplier: asecos

Safe active and passive storage of lithium-ion batteries.

Supplier: Thermo Orion

These bench top meters with pH/ISE, conductivity and Dissolved Oxygen/RDO modules meet the most challenging applications for pH, ion concentration, conductivity, dissolved oxygen and temperature. The meters offer interchangeable measurement modules that allow multiple users to customise four separate channels to meet their specific requirements.

Supplier: Hospidex

SYRINGE 10µL PLUNGER SUPPORT WITH TELESCOPIC PLUNGER FIXED NEEDLE 1 * 1 items

Supplier: Thermo Fisher Scientific

MODULE FP DIGITAL MCP NEW 0,5-10UL 1 * 1 items

Supplier: BDH Prolabo

LABEL CME,0HAZARD,72MMX174MM(UNPRINTED) 1 * 1 items

Supplier: BDH Prolabo

LABEL AME,2HAZARD,33MMX119MM(UNPRINTED) 1 * 1 items

Supplier: hünersdorff GmbH

JERRICAN BLACK 10L WITH SPOUT FOR FUEL UN 3H1/Y1.2/200/XX/A/PA-03/43395-huen 1 * 5 items

Supplier: MOLECULAR DEVICES

The SpectraMax® i3x multi-mode microplate reader is a configurable, versatile microplate reader that evolves with your future needs and allows you to investigate every aspect of a cellular pathway. The SpectraMax i3x microplate reader measures absorbance, luminescence and fluorescence as standard, and provides the flexibility to add novel detection capabilities without the need for service engineers or costly downtime - it grows with you as your research evolves.

Supplier: Bioss

Composed of more than ten subunits, the anaphase-promoting complex (APC) acts in a cell-cycle dependent manner to promote the separation of sister chromatids during the transition between metaphase and anaphase in mitosis. APC, or cyclosome, accomplishes this progression through the ubiquitination of mitotic cyclins and other regulatory proteins that are targeted for destruction during cell division. APC is phosphorylated, and thus activated, by protein kinases Cdk1/cyclin B and polo-like kinase (Plk). APC is under tight control by a number of regulatory factors, including CDC20, CDH1 and MAD2. Specifically, CDC20 and CDH1 directly bind to and activate the cyclin-ubiquitination activity of APCs. In contrast, MAD2 inhibits APC by forming a ternary complex with CDC20 and APC, thus preventing APC activation. APC10 contains a Doc1 homology domain, which is a beta-sandwich structure common to many other putative E3 ubiquitin ligases. APC10 binds to core APC subunits throughout the cell cycle. Specifically, APC10 binds to the C-terminus of CDC27/APC3. During mitosis, APC10 is localized in centrosomes and mitotic spindles. APC10 also localizes to kinetochores from prophase to anaphase, and to the midbody in telophase and cytokinesis.

Supplier: IKA

WASHER 1 * 1 items

Supplier: Roth Carl

DISINFECTION TUB MADE OF PVC 10L KLA 1 * 1 items

Supplier: Corning

10µl Pre-Sterilized Hamilton CO-RE Style Clear Filter Tip. 96 Tips per Rack, 5 Racks/pack, 12 packs/case 1 * 5.760 items

Supplier: Amarell

Soil therm., British type, similar specification, right angle, -7+38:0,5C, solid stem, white backed, red special liquid, round bulb with diameter 11,5-14,0mm, built-in length 75mm (MK2B), lower part 100mm, suitable for government verification 1 * 1 items

Supplier: BANDELIN-ELECTRONIC

SONOREX SUPER RK 514, ULTRASONIC BATH, 35 KHZ, 230 V 50/60 HZ, ID 325X300X150 MM 13,5 L, S/S TIMER 1-15 MIN AND CONTINUOUS, DRAI N BALL COCK 1/2 , ULTRASONIC PEAK OUTPUT 860 W, HF-OUTPUT: 215 WEFF. 1 * 1 items

Supplier: BANDELIN-ELECTRONIC

SONOREX SUPER RK 510, ULTRASONIC BATH, 35 KHZ, 230 V 50/60 HZ, ID 300X240X150 MM 9,7 L, S/S TIMER 1-15 MIN AND CONTINUOUS, DRAIN BALL COCK 1/2 , ULTRASONIC PEAK OUTPUT 640 W, HF-OUTPUT: 160 WEFF. 1 * 1 items

Supplier: BANDELIN-ELECTRONIC

SONOREX SUPER RK 1028, ULTRASONIC BATH, 35 KHZ, 230 V 50/60 HZ, ID 500X300X200 MM 28 L, S/S TIMER 1-15 MIN AND CONTINUOUS, DRAIN BALL COCK 1/2 , ULTRASONIC PEAK OUTPUT 1200 W, HF-OUTPUT: 300 WEFF. 1 * 1 items

Supplier: BANDELIN-ELECTRONIC

SONOREX SUPER RK 52, ULTRASONIC BATH, 35 KHZ, 230 V 50/60 HZ, ID 150X140X100 MM 1,8 L, S/S TIMER 1-15 MIN AND CONTINUOUS, ULTRAS ONIC PEAK OUTPUT 240 W, HF-OUTPUT: 60 WEFF. 1 * 1 items

Supplier: Retsch GmbH

203mm Diameter Stainless Steel Test Sieve with Electroformed Sheet 1 * 1 items

Supplier: Hospidex

MICROSYRINGE 10µL GAS ANALYSIS MS/GF INTERCHANGEABLE NEEDLE 1 * 1 items

Supplier: Amarell

Density hydrometer, 1,060-1,120:0,001g/cm , ref. temp. 20C, with therm., 350mm long, special liquid 1 * 1 items

Supplier: BANDELIN-ELECTRONIC

SONOREX SUPER RK 156, ULTRASONIC BATH, 35 KHZ, 230 V 50/60 HZ, ID 500X140X100 MM 6 L, S/S TIMER 1-15 MIN AND CONTINUOUS, DRAIN B ALL COCK 1/4 , ULTRASONIC PEAK OUTPUT 640 W, HF-OUTPUT: 160 WEFF. 1 * 1 items

Supplier: SAMCO

General Purpose Transfer Pipettes, Large Bulb. Length 15,1 cm. Stem Diameter 6,1 mm. Overall Capacity 8,6 mL. Bulb Draw 4,7 mL. 21 drops per mL. 1 * 4.000 items

Supplier: HIRSCHMANN

Flask volumetric, capacity 10ml, USP individual certificate, class A, graduated, conformity certificate. 1 * 1 items

Supplier: CUSTOM MADE CHEMICALS LAB

MERCURY Hg - 10MG/L IN HCL FOR ICP-MS 1 * 100 mL