48150 Results for: "2-Methyl-l-proline+methyl+ester+hydrochloride&pageNo=8"

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Baicalein ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Lipoxygenase inhibitor

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HC-030031 ≥98% (by HPLC)

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A potent and selective TRPA1 inhibitor.

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AMG-9810 ≥98%

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TRPV1 antagonist.

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Fluphenazine-N-2-chloroethane 2HCl ≥98%

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A potent irreversible inactivator of calmodulin. Possesses potent antiproliferative and cytotoxic activity. It is also an irreversible D2 dopamine receptor antagonist.

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H-7 dihydrochloride ≥98% (by TLC)

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Inhibits PKA (Ki=3.0μM), PKG (Ki=5.8μM), MLCK (Ki=97μM) and PKC (Ki=6μM). Also inhibits myosin light chain kinase. Induces apoptotic DNA fragmentation and cell death. Inhibits telomerase activity in treated NPC-076 cells. Cell permeable.

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D-erythro-Sphingosine ≥98% (by TLC)

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Common component of cell membranes, often as phosphatidyl conjugates. Is a potent (IC50=1-3 µM) and selective inhibitor of protein kinase C. Inhibition is competitive with diacylglycerol, phorbol dibutyrate and Ca2+ and it also inhibits PKC activation by other lipids. It acts on an equimolar basis with 1,2-dioleoylglycerol and does not affect other kinases such as MLCK and PKA. It is active in intact cells and has been identified as an endogenous constituent in HL-60 cells, neutrophils, rat liver, and brain and mouse tissues. Other activities include inhibition of phosphatidate phosphohydrolase, Na+,K+-ATPase, CTP:phosphocholine cytidylyltransferase, calmodulin-dependent enzymes, binding of factor VII to tissue factor, binding of thyrotropin releasing hormone to its receptor and activation of EGF receptor kinase, phospholipase D and casein kinase II.

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CP-55,940 ≥98% (by HPLC)

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Cannabinoid receptor ligand.

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Sp-5,6-dichloro-cBIMPS ≥98% (by HPLC)

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PKA activator.

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7-Ethoxyresorufin ≥98%

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Cytochrome P450 substrate

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HNMPA-(AM)3 ≥98% (by TLC)

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HNMPA-(AM)3 is a cell-permeable analog of HNMPA. It inhibits insulin receptor tyrosine kinase activity (IC50=100 µM) and insulin-stimulated glucose oxidation in isolated rat adipocytes (IC50=10 µM). It has no effect on PKA (at concs. up to 1 mM) or PKC (at concs. up to 420 µM). Inhibits both serine and tyrosine autophosphorylation by the human insulin receptor. Does not affect protein kinase C (PKC) or cAMP-dependent protein kinase (PKA).

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K-252b ≥98% (by HPLC)

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General, cell permeable protein kinase inhibitor. Acts by binding to the ATP binding domain of the kinase. Potent inhibitor of Ca2+/calmodulin kinase II. Inhibits myosin light chain kinase (MLCK; Ki=0.147µM), cAMP- dependent protein kinase (PKA; Ki=0.09µM), protein kinase C (PKC; Ki=0.02µM), and cGMP-dependent protein kinase (PKG; Ki=0.1µM).

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Tyrphostin AG-126 ≥98% (by HPLC)

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AG-126 prevents lipopolysaccharide-induced lethal toxicity (septic shock) in mice. Administered at 1.5 mg/mouse, it reduced LPS-induced lethal toxicity from 95% to 10%. AG-126 greatly reduces LPS-induced tyrosine phosphorylation of p42MAPK in murine peritoneal macrophages at 50 µM. EGFR, Her-2/neu receptor or PDGF-R are not inhibited at 100 µM. Inhibits tyrosine kinase-dependent B cell receptor signaling.

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MK-886 ≥98% (by HPLC)

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Inhibitor of PPARα activation. Inhibits 5-lipoxygenase-activating protein (FLAP) and leukotriene biosynthesis. Binds to FLAP with high affinity and prevents the activation of 5-lipoxygenase. IC50’s for leukotriene biosynthesis: 2.5 nM in intact leukocytes; 1.1 µM in whole blood. Induces apoptosis through the mitochondrial pathway.

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SB216763 ≥98% (by TLC)

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Potent and selective inhibitor of GSK-3β (IC50=34nM). Stimulates glycogen synthesis in human liver cells and mimics other actions of insulin. Protects primary neurons from death induced by PI-3 kinase pathway inhibition suggesting therapeutic potential in neurodegenerative diseases and stroke. Reduces pulmonary inflammation and fibrosis in a mouse model.

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Sodium 4-phenylbutyrate ≥98% (by UHPLC)

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Weak histone deacetylase (HDAC) inhibitor. Induces differentiation, growth arrest and apoptosis in a number of cell lines. Protects against cerebral ischemic injury and displays neuroprotective effect in a mouse model of Huntington’s disease. Anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation. Shows chemical chaperone activity.

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2,3-Bis(2-hydroxyethylthio)-1,4-naphthalenedione ≥98% (by HPLC)

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A potent and selective inhibitor of Cdc25 phosphatase (Ki's for Cdc25A, B and C are 32, 96 and 40 nM respectively). NSC-95397 inhibits the growth of several human tumor cell lines and blocks G2/M cell cycle transition.

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Geldanamycin ≥98% (by TLC) (conjugated to FITC)

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A novel geldanamycin fluorescent probe that may be used in a fluorescence polarization assay for HSP90 inhibitors. May also be used for detection of cell surface HSP90.

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Midostaurin ≥98% (by TLC)

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Inhibitor of a variety of serine/threonine and tyrosine kinases, like protein kinase C (PKC), cyclic AMP-dependent protein kinase (PKA), S6 kinase, Akt (protein kinase B; PKB), epidermal growth factor receptor (EGFR) tyrosine kinase activity and others including KDR, VEGFR, PDGFR, c-kit and other receptor tyrosine kinases. Potently inhibits FLT-3 kinase including mutant forms found in acute myeloid leukemia in vitro and in vivo. Apoptosis inducer. Showed broad antiproliferative activity against various tumor cell lines. Selectively inhibits T lymphocyte production of TNF-α. Upregulates endothelial nitric oxide synthase (eNOS; NOS III). Abrogates tumor angiogenesis in vivo.

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Ar231453 ≥98% (by HPLC), yellow solid

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GPR119 activator.

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21-[4-(2,6-Di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]pregna-1,4,9[11]triene-3,20-dione maleate salt ≥98% (by TLC)

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Blocks lipid peroxidation

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Chaetomellic acid A ≥98% (by TLC)

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Potent inhibitor of farnesyltransferase in isolated enzyme assays (IC50=55nM) but is inactive in whole cells. Inhibition of farnesyltransferase is selective over geranylgeranyltransferase I and II (IC50=92µM and 34µM respectively).