25304 Results for: "2-Chloro-7-methylquinoline-3-methanol"

Supplier: MP Biomedicals

Phenazine methosulfate is an electron acceptor and carrier in enzyme systems. The oxidised form is yellow and the reduced form is colourless.

Supplier: MP Biomedicals

AEBSF hydrochloride is a covalent binding serine protease inhibitor, belongs to the family of irreversible sulphonyl fluoride inhibitors that block trypsin and chymotrypsin-type enzymes.

Supplier: Honeywell Chemicals

High quality inorganic and organic reference materials produced according to ISO 9001.

Supplier: Honeywell Chemicals

High quality inorganic and organic reference materials produced according to ISO 9001.

Supplier: Honeywell Chemicals

High quality inorganic and organic reference materials produced according to ISO 9001.

Supplier: Honeywell Chemicals

High quality inorganic and organic reference materials produced according to ISO 9001.

Supplier: Cytiva

SDS is an ionic detergent used to solubilise proteins. The PlusOne™ SDS reagent is carefully controlled for carbon chain length and overall quality.

Supplier: Thermo Fisher Scientific

Phorbol-12-myristate-13-acetate 95%

Supplier: ProSci Inc.

Anti-PRF1 Rat Monoclonal Antibody

Supplier: MP Biomedicals

Hygromycin B is an aminoglycoside antibiotic produced by the bacterium Streptomyces hygroscopicus that kills bacteria, fungi and higher eukaryotic cells by inhibiting protein synthesis.

Supplier: MP Biomedicals

2-Hydroxypropyl-beta-cyclodextrin are non-toxic solubilisers. The solubility of drugs increases linearly with the concentration of 2-Hydroxypropyl-b-cyclodextrin in aqueous buffer. The formation of drug/cyclodextrin complexes is a rapidly reversible reaction and complexes exist both in solution and crystalline states.

Supplier: MP Biomedicals

Aztreonam is the first totally synthetic monocyclic β-lactam antibiotic that displays a high degree of resistance to β-lactamase degradation. It has high specificity for gram-negative aerobic rods.

Supplier: ENZO LIFE SCIENCES

Inhibitor of the JNK/p38 pathways. Inhibits anisomycin-induced but not TNF-induced JNK/p38 activation. Potent protein kinase inhibitor
>A naturally isolated cell-permeable fungal resorcylic lactone that acts as a selective and highly potent inhibitor against the MAPKKK TAK1 activity (IC50 = 8nM) in an ATP-competitive and irreversible manner; also inhibits MEK1 (IC50 = 411nM) and three other MAPKKKs (IC50 ≥268 nM against MEKK1, ASK1, and MEKK4) but at much higher concentrations. Shown to inhibit IL-1-induced/TAK1-mediated, but not H2O2-induced/TAK1-independent, JNK and p38 phosphorylation in 293 cells.

Supplier: MP Biomedicals

Dimethyl sulfoxide is a dipolar, aprotic solvent. Has been shown to accelerate strand renaturation (1-10% concentration) and is believed to give the nucleic acid thermal stability against depurination. By heating the solid form to approximately 30 °C, the product can be melted without harming it's stability.

Supplier: MP Biomedicals

Phenylmethylsulfonyl fluoride is an irreversible inhibitor of serine proteases - inhibits trypsin, chymotrypsin and protease. Inhibits mammalian acetyl cholinesterase, but not those from fish sources.

Supplier: MP Biomedicals

Antipain inhibits trypsin, papain, and catherpsins A and B (a reversible inhibitor of cysteine and serine proteases). It is used to evaluate the role of proteases in cell transformations. It is used to help identify new proteases.

Supplier: EDVOTEK

In this experiment, students study the diversity of fish using pre-stained, lyophilised proteins. Total protein from perch, walleye and salmon is extracted and pre-stained using an indicator dye. Each fish protein sample has a characteristic banding pattern when separated by denaturing SDS-polyacrylamide gel electrophoresis, which can be used to identify the specific species.

Supplier: ENZO LIFE SCIENCES

Anabaenopeptins are a highly diverse group of bioactive peptides produced by several genera of cyanobacteria such as Anabaena, Planktothrix, Microcystis and Nodularia. These peptides are commonly detected in cyanobacterial blooms along with the well known microcystins. Unique cyclic peptides where lysine is conserved in position 2 and cyclisation is achieved by linkage of the lysine to the C-terminal amino acid. In addition the side chain of a single amino acid is attached via a ureido bond. Bioactive peptides originally isolated from Anabaena flos-aquae NRC 525-17 where they were shown to be non-toxic in mice but had dose dependant relaxations in rat aortic preparations with endothelium precontracted with 0.1µM norpinephrine.
Anabaenopeptins inhibit protein phosphatase.

Supplier: ENZO LIFE SCIENCES

PD-98059 is a potent and selective inhibitor of MAP kinase kinase (MEK). It selectively blocks the activation of MEK thereby inhibiting the phosphorylation and the activation of MAP kinase. PD-98059 is cell permeable. In PC12 pheochromocytoma cells, it completely blocked the increase in MAP kinase activity produced by NGF, IC50=2µM. Enhances self-renewal of embryonic stem cells PD-98059 is an invaluable tool to help elucidate the role of the MAPK cascade in a variety of biological systems. Inhibits cell growth and proliferation in acute myelogenous leukemia cell lines by causing cell arrest.

Supplier: MP Biomedicals

Menadione belongs to the Vitamin K class of compounds, which are necessary for the biosynthesis of prothrombin and other blood clotting factors. Menadione has demonstrated cytotoxic activity against a variety of cell culture lines and can induce apoptosis of cultured cells, such as osteoclasts and osteoblasts, via elevation of peroxide and superoxide radical levels.

Supplier: ENZO LIFE SCIENCES

Irreversible inhibitor of serine proteases. Widely used fatty acid amid hydrolase (FAAH) inhibitor for pretreatment of brain membrane preparations when testing CB1 receptor activity. Spleen membranes used for CB2 studies do not require this pretreatment, as FAAH activity is absent in these cells. Inhibits also cysteine proteases like papain (reversible by DTT treatment, as well as internucleosomal DNA fragmentation in immature thymocytes. For a related, more stable inhibitor see AEBSF.

Supplier: ENZO LIFE SCIENCES

Highly specific, potent, irreversible, and cell-permeable competitive inhibitor of proprotein convertases: furin/SPC1 (Ki~1 nM), SPC2/PC2 (Ki=0.36nM), SPC3/PC1/PC3(Ki= 2,0nM), SPC4/PACE4 (Ki=3,6 nM), SPC6/PC5/PC6, and SPC7/LPC/PC7/PC8 (Ki=0,12 nM). Because furin activates viral glycoproteins, this inhibitor is a useful antiviral agent. In addition, it inhibits furin-dependent pro-MMP-2 activation in various cell lines, including U87 and HT1080 cells. Typical concentration range used in tissue culture is 25 to100 µm.

Supplier: MP Biomedicals

Urea is a mild agent usually used in the solubilization and denaturation of proteins. It is also useful for renaturing proteins from samples already denatured with 6 M guanidine hydrochloride such as inclusion bodies; and in the extraction of the mitochondrial complex.

Supplier: MP Biomedicals

CHAPSO is the hydroxy analog of CHAPS; a non denaturing zwitterionic detergent for solubilising proteins, especially integral membrane proteins while maintaining the functional capability of the protein of interest.

Supplier: CHIRAL TECHNOLOGIES

CROWNPAK® CR(+) and CR(-) contain a chiral crown ether as a chiral selector, which is coated onto a 5 µm silica support. CROWNPAK® selectors are mainly used to separate chiral amino acids and other small molecules with primary amine groups. The elution order of the enantiomers can be reversed when necessary.

Supplier: MP Biomedicals

Bleomycin Sulfate is an atineoplastic antibiotic. A mixture of cytotonic glycopeptide antibiotics which reacts with DNA and causes strand scission; they have also been shown to have a type of oxygen transferase activity. Bleomycin A2 is the main component of the bleomycin employed clinically. Bleomycins differ from one another in the terminal amine and show varying biological activity.

Supplier: Biotium

This kit is designed to measure Renilla luciferase activity in transfected cell reporter gene assays.

Supplier: Thermo Fisher Scientific

Copper(II) sulphate pentahydrate 98.0-102.0% ACS

Supplier: MP Biomedicals

Butylated hydroxytoluene is a phenolic antioxidant.

Supplier: MP Biomedicals

Rapamycin binds to and inhibits the molecular target of rapamycin (mTOR). It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). Rapamycin is a potent immunosuppressant and has anticancer activity.