Supplier: Bioss

Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.

Supplier: Biosensis

LRRK2 is a member of the leucine-rich repeat kinase family. Its role is yet unknown but it may play a role in the phoshorylation of proteins central to parkinson diseases. LRRK2 contains an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain and a WD40 domain. LRRK2 is present in the cytoplasm but also associates with the mitochondrial outer membrane. Defects in LRRK2 are the cause of Parkinson disease 8 (PARK8). Parkinson disease is characterised by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK8 is an autosomal-dominant late-onset parkinsonism, characterized by onset from 50 to 65 years, with slow progression and relatively benign course.

Supplier: Abcam

Angiotensin II ELISA kit is a competitive ELISA assay for the quantitative measurement of Ang II in Human serum, plasma, tissue homogenates and other biological fluids.

Supplier: ANTIBODIES.COM

Human TGF beta Receptor I ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human TGF beta Receptor I in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: ANTIBODIES.COM

Human TATA binding protein TBP ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human TATA binding protein TBP in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: ANTIBODIES.COM

Rat TGF beta Receptor I ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of rat TGF beta Receptor I in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: ANTIBODIES.COM

Canine beta Nerve Growth Factor ELISA Kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of canine beta Nerve Growth Factor in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: ANTIBODIES.COM

Rat beta nerve growth factor ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of rat beta nerve growth factor in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: EPPENDORF

Eppendorf Tubes® 3810X microtubes (1,5 ml) are designed for seamless one-handed operation with an easy-to-open, securely closing tube design. Perfect for sample preparation, centrifugation, and storage, these tubes will effortlessly integrate into workflows for efficient and reliable performance.

Supplier: LABCONCO

Protector premier hoods are suitable for general chemistry applications and also explosion-proof models are available for laboratories with potentially explosive/flammable atmospheres. Hoods are available with a built-in standard fiberglass blower, or an explosion-proof fiberglass blower, or without a blower (remote blower sold separately).

Supplier: ANTIBODIES.COM

Mouse NF-kB p65 ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of mouse NF-kB p65 in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: ANTIBODIES.COM

Rat G-Protein Coupled receptor 30 ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of rat G-Protein Coupled receptor 30 in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: ProSci Inc.

DEDAF Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD) death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. Several molecules including caspases and adaptor FADD contain DEDs. A novel protein that interacts with DED of caspase-8 and 10, and FADD was identified recently and designated DEDAF for DED associated factor. DEDAF is identical to the transcriptional repressor RYBP. DEDAF/RYBP is expressed in multiple tissues and cell lines. DEDAF interacts with FADD and augments the formation of CD95/FADD/capase-8 complexes at the cell membrane, and interacts with DED-containing DNA biding protein (DEDD) in the nucleus indicating it is involved in the regulation of both cytoplasmic and nuclear events of apoptosis.

Supplier: ProSci Inc.

Synapsin I plays a key role in synaptic plasticity in brain. This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. In addition to its role in plasticity, the expression of synapsin I is a precise indicator of synapse formation. Thus synapsin I immunocytochemistry provides a valuable tool for the study of synaptogenesis. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation. Serine 9 is the site on synapsin I that is phosphorylated by cAMP-dependent protein kinase and by calcium calmodulin kinase I. Phosphorylation of this site is thought to regulate synaptic vesicle function.

Supplier: ANTIBODIES.COM

Human CaMKII delta ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human CaMKII delta in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: ANTIBODIES.COM

Human Serum Response Factor SRF ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human Serum Response Factor SRF in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: ANTIBODIES.COM

Human Scavenging receptor SR-BI ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human Scavenging receptor SR-BI in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: ANTIBODIES.COM

Mouse ZO1 Tight Junction Protein ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of mouse ZO1 Tight Junction Protein in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: Biosensis

The causes and effects of neuronal degeneration are of major interest to a wide variety of neuroscientists. Paralleling this growing interest is an increasing number of methods applicable to the detection of neuronal degeneration. Fluoro-Jade C stains all degenerating neurons regardless of specific insult or mechanism of cell death. Fluoro-Jade C exhibits the greatest signal to background ratio, as well as the highest resolution. This translates to a stain of maximal contrast and affinity for degenerating neurons. This makes it ideal for localising not only degenerating nerve cell bodies but also distal dendrites, axons and terminals. The dye is highly resistant to fading and is compatible with virtually all histological processing and staining protocols.

Supplier: ANTIBODIES.COM

Human PI 3 Kinase p110 delta ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human PI 3 Kinase p110 delta in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: ANTIBODIES.COM

Mouse Pyruvate Kinase Isozyme M1 ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of mouse Pyruvate Kinase Isozyme M1 in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: ANTIBODIES.COM

Rabbit beta Nerve Growth Factor ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of rabbit beta Nerve Growth Factor in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: ANTIBODIES.COM

Human p75 NGF Receptor ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human p75 NGF Receptor in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: ANTIBODIES.COM

Mouse beta Nerve Growth Factor ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of mouse beta Nerve Growth Factor in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: Thermo Fisher Scientific

Thermo Scientific Pierce Sulfo-LC-SDA (Sulfo-NHS-LC-Diazirine) combines proven NHS-ester and diazirine-based photoreaction chemistries with conjugate amine-containing molecules with nearly any other functional group via long-wave UV-light activation. A 12.5Å spacer arm separates the two photoreactive groups.

Supplier: Thermo Fisher Scientific

Thermo Scientific Pierce Sulfo-SDAD (Sulfo-NHS-SS-Diazirine) combines proven NHS-ester and diazirine-based photoreaction chemistries with conjugate amine-containing molecules with nearly any other functional group via long-wave UV-light activation. A 13.5Å spacer arm containing a cleavable disulfide bond separates the two photoreactive groups.

Supplier: BIGNEAT

Chemcap™ Clearview™ ductless fume hoods include Chemcap™ carbon filtration. A range of six standard cabinet sizes with keypad control panel, touch button controls and service due indicator. Includes 18 W fluorescent lamp and PVC base tray which offers excellent chemical resistance and contains spillages.
Cabinets are manufactured from polyester coated steel; transparent panels are acrylic and resistant to corrosion.

Supplier: ANTIBODIES.COM

E. coli Host Cell Proteins ELISA Kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of E. coli Host Cell Proteins in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: ANTIBODIES.COM

Mouse Insulin degrading enzyme/IDE ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of mouse Insulin degrading enzyme/IDE in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: ANTIBODIES.COM

Rat ZO1 Tight Junction Protein ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of rat ZO1 Tight Junction Protein in serum, plasma, tissue homogenates, and other biological fluids.