43536 Results for: "[5-(Trifluoromethyl)-1-benzothiophen-2-yl]methanol"

Supplier: MP Biomedicals

Acrylic Acid Content ≤0,001%

Supplier: VWR Chemicals

The level of volatile organic solvents in pharmaceutical raw materials or finished product is defined and monitored. Residual solvents are classified according to their risk assessment classes. A selection of residual solvent standards is now available from Avantor.

Supplier: ENZO LIFE SCIENCES

Macrocyclic-triene antibiotic possessing potent immunosuppressant activity. It forms a complex with FKBP12 that binds to an effector, thus inhibiting IL-2 and other growth promoting lymphokines. The effectors were identified as FRAP (FKBP12 rapamycin-associated protein) and RAFT1 (rapamycin and KFBP12 target). Rapamycin/FKBP complex does not inhibit FRAP PI 4-kinase activity, but does inhibit FRAP autophosphorylation. Rapamycin induces inhibition of p70^s6k, p33^cdk2 and p34^cdc2. Selectively blocks signaling leading to the activation of p70/85 S6 kinase. Enhances apoptosis. Activator of autophagy both in vitro and in vivo.

Supplier: Brady

Mass transit tag complies with minimal smoke and halogen emission requirements of the most strict underground norms for mass transit vehicles.

Supplier: MP Biomedicals

Heparin is a polymer classified as a mucopolysaccharide or a glycosoaminoglycan. It is biosynthesized and stored in mast cells of various mammalian tissues, particularly liver, lung and mucosa. It is made up of repeated disaccharide units consisting of 1,4-linked L-iduronic acid and D-glucosamine. The iduronic acid residues are O-sulfated at position 2, and the glucosamine residues are N-sulfated and O-sulfated at position 6. The repeated block can be interrupted or extended by residues of beta-D-glucuronic acid and 6-O-sulfated N-acetyl-alpha-D-glucosamine.

Supplier: MP Biomedicals

Tris is an established basimetric standard and buffer used in biochemistry and molecular biology.

Supplier: MP Biomedicals

Succinic acid is a dicarboxylic acid that occurs in nature in such organisms as fungi and lichens. In eukaryotes, succiniate, the anion of succinic acid, is an intermediate in the citric acid cycle, being formed from succinyl CoA and being converted to fumarate. Bacteria and plants can produce succinate from acetate or acetyl CoA, in the glyoxylate cycle.

Supplier: MP Biomedicals

Urea is a mild agent usually used in the solubilization and denaturation of proteins.

Supplier: Corning

Multiple formats for specific and precise fit on 96-well and 384-well plates and blocks.

Supplier: Cytiva

DEAE Sephacel™ is a weak anion exchanger based on beaded cellulose. The ion exchange group is diethylaminoethyl, which remains charged and maintains consistently high capacity over the entire working range. This media is macroporous and has an exclusion limit of ~10000 kDa for globular proteins. Supplied pre-swollen in 20% ethanol.

Supplier: MP Biomedicals

Tetracycline is a broad spectrum polyketide antibiotic with clinical uses in treating bacterial infections such as Rocky Mountain spotted fever, typush fever, tick fevers, Q fever, and Brill-Zinsser disease and to treat upper respiratory infections and acne. It has been used in studies of multidrug resistance and potential side effects including acute pancreatitis.

Supplier: Brady

Increase safety and visibility with the B-584 highly-reflective label material. Print labels almost anywhere high visibility is needed with a compact Brady handheld label printer.

Supplier: AAT BIOQUEST

Gentamicin is widely used for treating tuberculosis and Gram-negative infections and is particularly useful in neonatal intensive care units. Fluorophore-tagged drugs, such as gentamicin-Texas Red (GTTR) conjugates, have been used to identify drug trafficking routes across the BLB and into hair cells, and specifically in the cochlea - the sensory organ responsible for hearing. Identifying the mechanisms involved in the intracochlear trafficking of ototoxic drugs to hair cells is of fundamental as well as clinical importance. Texas Red-gentamicin conjugate (GTTR) provides researchers a valuable tool to study the cellular uptake, kinetics and distribution of gentamicin through fluorescence techniques, such as fluorescence microscopy, fluorescence correlation spectroscopy, single molecule spectroscopy. The TR fluorophore can be conveniently excited from 500-600 nm, with an emission maximum centered around 610 nm. Acute nephrotoxicity and permanent ototoxicity are serious side-effects that increase patient morbidity, or induce permanent auditory and vestibular deficits. Several approaches have been used to study the intracellular mechanisms induced by ototoxic drugs. However, ototoxic drugs must first cross the blood-labyrinth barrier (BLB) before entering sensory hair cells to exert their cytotoxic effect that leads to hearing loss and deafness. The BLB is similar to the blood-brain barrier (BBB), and is composed of tight junction-coupled endothelial and epithelial barrier layers that transport nutrients and ions from one side of the barrier to the other.

Supplier: Brady

B-8591 outdoor, harsh-environment labels resist UV, abrasions, high temperatures, fluids and washdowns, and are an ideal print-on-demand thermal transfer label solution.

Supplier: MP Biomedicals

Vincristine Sulfate, a dimeric Vinca alkaloid. Experiments have reported Vincristine Sulfate to demonstrate a capacity to suppress growth of proliferating cells through marked apoptosis. The cell death caused by this agent seems to result in a sustained accumulation of endogenous ceramide levels. Ceramide, has been proposed as a lipid second messenger with specific antiproliferative mediating responses.

Supplier: MP Biomedicals

Rotenone is a naturally occurring botanical compound obtained from the roots of Derris sp.& Cube. It is an inhibitor of mitochondrial electron transport, specifically inhibiting NAD-linked substrate oxidation by mitochondria at the oxygen side of NADH dehydrogenase.
Rotenone is utilized as an insecticide. It can be used as neurotoxic agent that can produce a Parkinson-like condition as an animal model for study of etiology and interventions.
Inhibitor of mitochondrial electron transport at NADH: ubiquinone oxidoreductase. It is readily absorbed through the exoskeletons of arthropods, but poorly absorbed cutaneously or from the gastrointestinal tract of mammals. Rotenone is used to induce a Parkinson-like syndrome as an experimental model in rats.

Supplier: Brady

The B-494 polyester label is a reliable sample identification and traceability solution. The label will stay attached and remain legible, even when exposed to chemicals or stored in liquid nitrogen.

Supplier: Whatman products (Cytiva)

SPARTAN syringe filters with regenerated cellulose (RC) membrane provide reproducible filtration of organic and aqueous solutions for high performance and ultra-high performance liquid chromatography (HPLC and UHPLC) sample preparation.

Supplier: Restek

Raptor™ Biphenyl column is extremely useful for fast separations in bioanalytical testing applications like drug and metabolite analyses, especially those that require a mass spectrometer (MS).

Supplier: MP Biomedicals

Urea is a prinicipal protein metabolite end product of nitrogen metabolism in most mammals, formed by the enzymatic reactions of the Kreb's cycle and the major product for the removal of free ammonia (NH4+) in vivo.

Supplier: Restek

Force Biphenyl LC HPLC Columns are ideal for bioanalytical testing applications like drug and metabolite analyses.

Supplier: Brand

Seal-R-film™ sealing film seals beakers, flasks, and other vessels.

Supplier: MP Biomedicals

Bromelain is a glycoprotein which is a highly active thiol proteinase (non-specific cysteine protease), which splits glycine esters but not lysine esters; it is also a protein-digesting and milk-clotting enzyme. Substrates susceptible to bromelain include all of the common protein materials such as gelatin, casein, gluten, collagen, elastin, globulins an muscle fiber protein. It is a cysteine endopeptidase with broad specificity for cleavage of proteins. It may be from a stem or piece of fruit.

Supplier: THERMO SAVANT

Savant™ SpeedVac™ medium capacity vacuum concentrators evapourate strong acids, bases, and aggressive organic solvents. Approved for combinatorial chemistry, these concentrators incorporate an intuitive programmable user display for enhanced usability.

Supplier: ANTIBODIES.COM

Rabbit polyclonal antibody to VPS72 for WB, IHC and ELISA with samples derived from Human and Mouse.

Supplier: Brady

Durable, low-shrink vinyl with our most aggressive adhesive. Conforms to irregular, curved, rough and highly textured surfaces (painted cinder blocks, uneven wood, textured plastics, paper-jacketed pipes, powder-coated surfaces). Adheres to 'difficult' low-surface energy items (PVC piping, blow-molded equipment cases, ABS plastics, recycled plastics).

Supplier: Brady

Permanent vinyl (B-439) is a thermal transfer printable material ideal for applications needing various colours like finished product ID, rating plates, and general-purpose ID.

Supplier: Brady

This durable, low-shrink vinyl with ultra-aggressive adhesive is the perfect solution for identification on rough surfaces and in harsh environment areas.

Supplier: Brady

This durable, low-shrink vinyl with ultra-aggressive adhesive is ideal for labelling pipes, equipment, shelves, and nearly any other industrial surface.

Supplier: Brady

PermaSleeve® PS heat-shrink polyolefin (B-342) wire marking sleeves combine speed, ease of use and permanence to create long-lasting, high quality identification.