48200 Results for: "(Bromomethyl)cyclohexane&pageNo=8"
[pSer95, Ala97]-RII (81-99)
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Calcineurin substrate
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Actinomycin D (from Streptomyces parvulus) ≥98% (by TLC)
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An intercalating transcription inhibitor and antineoplastic antibiotic. Inhibits transcription by binding to DNA at dG residues. Induces apoptosis in many cell lines, but suppresses in PC12 cells induced by topoisomrease II inhibitor etopside. Used at 5-10 µg/mL in cell culture for halting transcription. The product is not sterile.
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Z-Guggulsterone ≥98%
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A guggul tree steroid well known for its lipid lowering properties. Acts as a selective antagonist at farnesoid X receptors (FXRs). Inhibits FXR transactivation (IC50=10µM).
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Ro 41-5253 ≥98% (by TLC)
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Retinoic acid receptor ligand
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Mono-n-dodecyl phosphate ≥98% (by TLC), white to off-white solid
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Lysophosphatidic acid (LPA) receptor ligand. A specific agonist at LPA2 (EC₅₀=700 nM) and antagonist at LPA.
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WEB-2086 ≥98% (by HPLC)
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PAF receptor antagonist. Inhibits PAF-induced human platelet and neutrophil aggregation in vitro (IC50=0.17 and 0.36µM respectively). In vivo it dose dependently blocks eosinophil activation and displays antiallergic and anti-inflammatory activity in various models. Induces differentiation and triggers apoptosis and in a variety of cell lines.
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Bupropion hydrochloride ≥98% (by TLC)
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Inhibitor of dopamine and norepinephrine transporters
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Histone Deacetylase Inhibitor VIII ≥98% (by TLC)
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HDAC6 inhibitor
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5(S)-Hydroxyeicosa-6E,8Z,11Z,14Z-tetraenoic acid (HETE) ≥98%
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Biosynthesis via 5-lipoxygenase. Chemotactic and chemokinetic for PMNL. Induces degranulation and calcium flux.
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Cp 31398 Dihydrochloride (synthetic) ≥98% (by TLC)
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CP-31398 restores mutant p53 tumor suppressor function in vitro without affecting p53 homologs p63 and p73, and in vivo inhibiting UVB-induced skin carcinogenesis in mice. Stabilization of p53 inhibits ubiquitination without altering phosphorylation at Ser12 or Ser20 or MDM2 binding. Administration of this or similar compounds has the potential to enhance cytotoxic chemotherapy.
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Calpeptin ≥98% (by TLC)
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Calpain and cathepsin inhibitor
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3,4-Dichloroisocoumarin ≥98% (by elemental analysis)
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A potent irreversible mechanism based serine protease inhibitor. Inhibits granzymes A, B, and H, cathepsin G, neutrophil elastase and proteinase 3. Inhibits activation of neutral sphingomyelinase and apoptosis triggered by daunorubicin as well as camptothecin-induced apoptosis in HL-60 cells. Inhibits migration of eosinophils through basement membrane components in vitro.
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Zardaverine ≥98% (by HPLC)
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Selective, dual inhibitor of PDE III and PDE IV (IC50s=2.5 and 1.1 µM respectively). Anti-allergic activity, combined inhibition of PDE III and IV have an additive synergistic effect on inhibition of guinea pig bronchospasm.
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R-(-)-Rolipram ≥98% (by HPLC)
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R-enantiomer of rolipram which is more active at inhibition of PDE IV, Ki=06 µM. 10-fold more active than S-rolipram at inhibition of PDE IV. Inhibits antigen-induced contraction of guinea-pig colonic smooth muscle, EC50=0.1 µM.
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N,N,2-Trimethyl-5-nitrobenzenesulphonamide (synthetic) ≥98% (by TLC)
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The first selective PDE7 inhibitor (Ki=180 nM).
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Sivelestat sodium ≥98% (by HPLC)
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Potent and selective leukocyte elastase inhibitor (IC50=44nM). Displays various anti-inflammatory activities including attenuation of LTB4-induced neutrophil migration and serum cytokine levels. Reduces acute inflammatory lung injury in vivo.
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PF-356231 ≥98% (by TLC)
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Specific non-chelating small-molecule inhibitor of MMP-12 (IC50 = 14 nM). At higher concentrations it inhibits other MMPs, but spares MMP-1, making it a valuable tool for investigation of MMP activity and function.
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Gabexate mesylate ≥98% (by HPLC)
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A competitive, reversible inhibitor of serine proteases tryptase (Ki=3.4nM), thrombin (Ki=500nM), uPA (Ki=1.3µM), plasmin (Ki=1.5µM), trypsin (Ki=2µM), factor Xa (Ki=2µM). At higher concentrations it inhibits kallikrein-1 (Ki=2.6mM), C1 esterase (IC50=520µM), as well as phospholipase A2 (IC50=500µM), rat iNOS (Ki=5mM) and cNOS (Ki=150µM), and swine kidney copper amine oxidase (Ki=27µM), but not chymotrypsin. Has been used in tissue culture and in vivo. In clinical use for pancreatitis.
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Argatroban ≥98% (by HPLC)
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Argatroban is a synthetic peptidomimetic thrombin inhibitor which is in clinical use. It presents significant advantages as an anticoagulant in deep vein thrombosis, stroke prevention in atrial fibrillation and thromboembolic disease and especially in patients with coronary artery disease and heparin-induced thrombocytopenia.
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Rotenone ≥98% (by HPLC)
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Rotenone ≥98% (by HPLC)
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Pseudohypericin ≥98% (by HPLC, TLC)
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Inhibitor of PKC and dopamine beta-hydroxylase
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R-sulphoraphane ≥98% (by UPLC)
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Carciogenesis inhibitor
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Doxycycline hyclate ≥98% (dried basis)
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MMP inhibitor
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Leptomycin B 0,2 mg/ml ≥98% (by HPLC)
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A potent and specific nuclear export inhibitor. In addition to antifungal and antibacterial activities, blocks the cell cycle and is a potent anti-tumor agent.
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S-Nitrosoglutathione (GSNO) ≥98% (by TLC)
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Nitric oxide donor
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Supplier: BOCHEM
Supplier: VWR Collection
Supplier: OMEGA BIO-TEK
Supplier: DWK Life Sciences
Supplier: Thermo Fisher Scientific
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Supplier: Oxford Nanopore Technologies
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Supplier: Integra
Supplier: Palbam
Supplier: VWR Collection
Supplier: Integra
Supplier: VWR Collection
Supplier: FACELLITATE
Supplier: NANOENTEK
Supplier: Greiner Bio-One