167437 Results for: "(6-Bromoimidazo[1,2-a]pyridin-2-yl)acetic+acid"

Supplier: TRESTON

Cupboard fixing bracket bottom/top left, grey 1 * 1 items

Supplier: TRESTON

Upper/Lower self,2250 1 * 1 items

Supplier: Brand

PP, non skirted. Manufactured under cleanroom conditions, and made from pure, high quality materials (without additives) these PCR plates are suitable for use with most commercially available thermal cyclers.

Supplier: ProSci Inc.

The enzyme 5-lipoxygenase (5-LO) plays a key role in regulating the production of leukotrienes (LTs) (Funk, 2001). Overproduction of LTs contributes to several diseases, most notably chronic inflammatory diseases, including asthma (Drazen et al., 1994), fibrosis (Wilborn et al., 1996) and atherosclerosis (Dwyer et al., 2004). Recent work has demonstrated that the activity of 5-LO is regulated by PKA phosphorylation of serine-523 in 5-LO (Luo et al., 2004). Under normal conditions, this phosphorylation may be important in limiting inflammation. Abnormal signaling through cAMP and PKA, then, could contribute to a variety of diseases, including those characterized by chronic inflammation. The phospho-specific antibody to Ser523 on 5-LO is thus likely to provide a valuable tool for studies of the role of 5-LO regulation in diseases such as asthma, fibrosis and atherosclerosis.

Supplier: TRESTON

Upper/Lower self,1500x370 (50kg) 1 * 1 items

Supplier: MACHEREY-NAGEL

Filter paper folded MN 606 1/4 12.5cm diameter, pack of 100. 1 * 100 items

Supplier: MACHEREY-NAGEL

Filter paper folded MN 611 1/4 12.5cm diameter, pack of 100. 1 * 100 items

Supplier: DWK Life Sciences

Tube centrifuge, ar-glass, 101x 16 5x1 2mm, short, conical. 1 * 100 items

Supplier: MACHEREY-NAGEL

Filter paper folded MN 621 1/4 12.5cm diameter, pack of 100. 1 * 100 items

Supplier: MACHEREY-NAGEL

Filter paper folded MN 875 1/4 12.5cm diameter, pack of 100. 1 * 100 items

Supplier: MACHEREY-NAGEL

Filter paper folded MN 652 1/4 12.5cm diameter, pack of 100. 1 * 100 items

Supplier: MACHEREY-NAGEL

Filter paper folded MN 960 1/4 12.5cm diameter, pack of 100. 1 * 100 items

Supplier: MACHEREY-NAGEL

Filter paper folded MN 704 1/4 12.5cm diameter, pack of 100. 1 * 100 items

Supplier: MACHEREY-NAGEL

Filter paper folded MN 625 1/4 12.5cm diameter, pack of 100. 1 * 100 items

Supplier: MACHEREY-NAGEL

Filter paper folded MN 918 1/4 12.5cm diameter, pack of 100. 1 * 100 items

Supplier: MACHEREY-NAGEL

Filter paper folded MN 605 1/4 12.5cm diameter, pack of 100. 1 * 100 items

Supplier: PROVITRO

The supplement kit for endothelial cell proliferation medium is suitable for culturing Provitro human endothelial cells after adding the supplement kit components to 500 ml basal medium The formulation is optimised for initial seeding of 4000 cells/cm² up to confluence (approx. 90%). Feeder-layer, matrix substrates or other substances are not necessary. Due to the possibility of reduced proliferative activity we recommend to use the antibiotic supplement for freshly isolated cells only. The supplement kit for endothelial cell priliferation medium is thoroughly tested after each production. All components are tested in a stringent biological assay. Each batch is checked for human endothelial cells proliferating characteristics. The cells cultured in endothelial cell growth medium are checked regarding their morphology, the adherence rate, the colony forming efficiency and the population doubling time.

Supplier: Bioss

Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen. Isoform 1E may regulate the formation of functional GABBR1/GABBR2 heterodimers by competing for GABBR2 binding. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites.

Supplier: MACRON AVANTOR BRAND

L(+)-Histidine monohydrochloride monohydrate 98.5-101.0%, Multi-Compendial, meets analytical specification of ChP, BP, JP, Ph. Eur., Macron Fine Chemicals™

Supplier: ProSci Inc.

14-3-3 proteins are a family of highly conserved proteins that appear to have multiple roles in cell signaling (Bridges and Moorhead, 2005). The proteins are abundantly expressed in the brain and have been detected in the cerebrospinal fluid of patients with different neurological disorders (Berg et al., 2003). 14-3-3 proteins bind protein ligands that are typically phosphorylated on
serine or threonine residues and regulate the functions of these binding partners by a number of different mechanisms (Silhan et al., 2004; Dougherty and Morrison, 2004). The14-3-3 proteins affect a diverse array of cellular processes including the cell cycle and transcription, signal transduction and intracellular trafficking. These functions of 14-3-3 proteins are facilitated by, if not dependent on, its dimeric structure. Recent work has demonstrated that the dimeric status of the 14-3-3 protein is regulated by site-specific serine phosphorylation (Woodcock et al., 2003).

Supplier: ProSci Inc.

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described.GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Supplier: MACRON AVANTOR BRAND

L(+)-Histidine monohydrochloride monohydrate 98.5-101.5% (dried basis), Multi-Compendial, Macron Fine Chemicals™

Supplier: Binder

The KBF series is ideal for reliable stability tests and precise maintenance of constant climatic conditions. Constant temperature and humidity values are the outstanding features of this range. These constant climate chambers with stainless steel interior have a large reserve capacity and a variety of optional features. They also comply with all applicable guidelines with respect to programs and documentation requirements, such as ICH, FDA, GMP and GLP. Units can be operated with Binder Pure Aqua Service, a flexible water purification system (optional) or deionised water.

Supplier: MP Biomedicals

Monopotassium Salt 1 * 25 mg

Supplier: MP Biomedicals

Monopotassium Salt 1 * 100 mg

Supplier: ProSci Inc.

EphrinB proteins are thought to play key roles in cellular functions as diverse as neuronal migration and blood vessel development (Flanagan and Vancerhaeghen, 1998; Dufour et al., 2003; Oike et al., 2002). EphrinB molecules expressed at the membrane surface bind to the EphB family receptors on target cells during cellto cell contact. This interaction leads to cell signaling in the target cell but also generates a reverse signal in the cell expressing EphrinB on its surface. This reverse signaling event is thought to be critical for vessel maturation and neuronal development. Importantly, tyrosine phosphorylation of EphrinB is thought to be a critical component of this reverse signaling event (Palmer et al., 2002). Recent work suggests that phosphorylation of a specific EphrinB residue (Tyr298) plays a key role in EphrinB signaling (Kalo, et al., 2001).

Supplier: Greiner Bio-One

Set blood collection Vacuette 23G x 3/4 inch with Luer adapter tubing length 30cm sterile 1 * 1.000 items

Supplier: MACHEREY-NAGEL

Filter paper circles MN 640 mf 12.5cm diameter, pack of 100. 1 * 100 items

Supplier: MP Biomedicals

Purity: 98%1 ml = approx. 0.93 g 1 * 100 mL

Supplier: MP Biomedicals

Crystalline Light yellow Purity: 99% 1 * 1 g