48150 Results for: "(4-Chlorosulphonyl-2-fluorophenoxy)acetic+acid+methyl+ester&pageNo=8"

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CGP-37157 ≥98% (by TLC)

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Potent, selective inhibitor of mitochondrial Na+Ca2+ exchange. IC50=0.4µM. Blocks mitochondrial permeability transition.

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An analog of antimycin A (mixture of antimycin A1, A2, A3 and A4) which binds to the hydrophobic groove of Bcl-2 and Bcl-X_L thereby inducing apoptosis. It displays selective cytotoxicity for Bcl-X_L-expressing cells (10 µg/ml). Unlike antimycin A it does not exhibit general mitochondrial toxicity.

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Indirubin-3'-oxime ≥98%

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A potent inhibitor of glycogen synthase kinase-3β (IC50=22 nM). Also inhibits CDK1 (p34cdc2; IC50=180 nM) and CDK5 (IC50=100 nM). It reversibly arrests asynchronous HBL-100 cells at G2. Induces apoptosis in the mammary carcinoma cell line MCF-7 (10 µM).

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K-252a ≥98%

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Protein kinase inhibitor

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Meclofenamic acid sodium salt ≥98% (by HPLC)

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Dual 5-lipoxygenase (IC50=46.8 µM) and cyclooxygenase I and II inhibitor (IC50=0.6 µM). Clinically useful NSAID.

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VDM-11 ≥98% (by TLC)

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Selective and potent inhibitor of the anandamide membrane transporter (AMT) (neuronal (C6 glioma cells): IC50=11µM; non-neuronal (rat RBL-2H3 cells): IC50=7.2µM) with negligible action at TRPV1 and weak action at CB1 receptor (CB1: Ki=5µM; CB2: Ki>5µM) and FAAH (IC50=3.7µM/ IC50>50µM (N18TG2 cell membranes).

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Rp-cAMPS ≥98% (by HPLC)

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Rp-cAMPS is a potent and specific competitive inhibitor of the activation of cAMP-dependent protein kinases by cAMP (IC50=4.9 µM) . Its cell permeability and complete resistance to cyclic nucleotide phosphodiesterases make it a unique tool for studying cAMP-dependent signaling. Significantly more lipophilc as compared to cAMP and thus membrane permeable in many biological systems. This product is not sterile.

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3-Morpholinosydnonimine ≥98% (by HPLC)

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SIN-1 is a metabolite of molsidomine which decomposes spontaneously in solution in the presence of oxygen, releasing NO and superoxide anion under physiological conditions. Since NO and superoxide react to form peroxynitrite, SIN-1 may actually produce peroxynitrite under physiological conditions. It is a potent vasodilator and inhibitor of platelet aggregation and produces significant protective effects in myocardial ischemia-reperfusion. The effects of SIN-1 are markedly attenuated by nitroglycerin-induced tolerance. Inhibits cysteine proteases.

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Chelerythrine chloride ≥98%

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PKC inhibitor

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KN-62 ≥98%

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CaM kinase inhibitor

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(R)-Ibuprofen ≥98%

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Less active enantiomer of ibuprofen.

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Tyrphostin AG-1296 ≥98% (by TLC)

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A potent inhibitor of PDGF receptor tyrosine kinase (IC50=1 µM). Also inhibits FGF receptor tyrosine kinase and c-kit. Induces apoptosis in a small-cell lung cancer cell line (H526).

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CL-82198 (MMP-13 inhibitor) ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

A novel and selective inhibitor of MMP-13 (89% at 33 µM). Acts via binding to the S1' pocket of MMP-13 without metal chelation.

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U-0126 ≥98% (by TLC)

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U-0126 (Bis[amino[(2-aminophenyl)thio]methylene]butanedinitrile) is a novel, potent and selective MEK inhibitor (MEK1; IC50=72nM, MEK2; IC50=58nM). Inhibits AP-1 transcription activity. Blocks the production of inflammatory cytokines and matrix metalloproteinases.

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SU4312 ≥98%

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Potent and selective inhibitor of VEGFR-2 (Flk-1, KDR). It displays a 100-fold greater potency for the unactivated form of the kinase (Ki=0.04µM) compared to the activated form (Ki=4µM).

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TMP-153 ≥98%

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TMP-153 is a potent and selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), IC50=5-10 nM. It inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters. ACAT inhibitors improve plasma lipid profile and ameliorate proteinuria in nephrotic animals.

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GW-441756 ≥98%

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TrkA inhibitor

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Triciribine ≥98% (by HPLC)

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Akt inhibitor

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SC-514 ≥98% (by TLC)

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IKK inhibitor

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SD-169 ≥98%

Supplier: ENZO LIFE SCIENCES

A selective inhibitor of p38α (IC50 = 3.2 nm) and p38β (IC50 = 3.2 nm), but not p38γ (IC50 > 50 μm), ERK2, JNK1 or MAPKAP2. Lowers blood glucose and improves glucose homeostasis in nonobese diabetic mice. Enhances axonal regeneration in animals with nerve transection.