12901 Results for: "(4-Chlorophenyl)acetic+acid&pageNo=60&view=list"

Supplier: HUBER

Quick release / Coupling M24x1,5 Temperature range: -75C...230C Connection: M24X1,5 AG Connection point: Tempering hose max. pressure at 20C: 25 bar Nominal size: 12 mm Note: When using ethanol as thermofluid: When ethanol is used as thermofluid: 1 * 1 items

Supplier: Thermo Scientific

The Heracell™ VIOS series has been designed for sensitive cultures like stem and primary cells in leading research, pharmaceutical and clinical applications. The units are available with either electropolished stainless steel or 100% pure copper interiors and have adjustable, perforated shelving, easy to clean corners with convenient access port and a reversible exterior door for added flexibility.

Supplier: ProSci Inc.

This mAb reacts with both SUMO-2 and SUMO-3. The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, 2 and 3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesised as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2 and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, 2 and 3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include MDM2, p53, Pml and RanGap1. SUMO-2 and 3 contribute to a greater percentage of protein modification than does SUMO-1 and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates beta-Amyloid generation and may be critical in the onset or progression of Alzheimer s disease.

Supplier: ProSci Inc.

Cytokeratin 8 is the product of the KRT8 gene and one of the most abundant keratins. The KRT8 gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Cytokeratin 8 participates in cellular differentiation and signal transduction, protects against apoptosis, stress and injury, and helps maintain cellular structural integrity. It is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Specific combinations of cytokeratins are associated with certain epithelial cells, and therefore useful in the characterization of poorly differentiated carcinoma. Hepatocellular carcinomas are defined by the use of antibody that recognises only cytokeratin 8 and 18. Keratin 8 exists on several types of normal and neoplastic epithelia, including many ductal and glandular epithelia such as colon, stomach, small intestine, trachea, and esophagus as well as in transitional epithelium. Antibody to Cytokeratin 8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against Keratin 8, 18 and 19). Reportedly, Cytokeratin 8 antibody is useful for the differentiation of lobular (ring-like, perinuclear) from ductal (peripheral-predominant) carcinoma of the breast.

Supplier: ProSci Inc.

Recognises a protein of 57 kDa, identified as p57Kip2. It shows no cross-reaction with p27Kip1. p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. Anti-p57 has been used as an aide in identification of complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts and stromal cells) from partial hydatidiform mole (PHM) in which both cytotrophoblasts and stromal cells stain. The histological differentiation of complete mole, partial mole, and hydropic spontaneous abortion is problematic. Most complete hydatidiform moles are diploid, whereas most partial moles are triploid. Ploidy studies will identify partial moles, but will not differentiate complete moles from non-molar gestations. Complete moles carry a high risk of persistent disease and choriocarcinoma, while partial moles have a very low risk. In normal placenta, many cytotrophoblast nuclei and stromal cells are labeled with this antibody. Similar findings apply to PHM and hydropic abortus tissues. Intervillous trophoblastic islands (IVTIs) demonstrate nuclear labeling in all three entities and serve as an internal control.

Supplier: ProSci Inc.

Recognises a disaccharide epitope, Gal1-3GalNAc, of Thomsen-Friedenreich (TF) antigen. It is specific for both anomeric forms of the disaccharide (TF and TF, including related structures on the glycolipid) and shows no cross-reactivity with sialylated glycophorin. The Thomsen-Friedenreich antigen acts as an oncofetal antigen, with low expression in normal adult tissues but increasing to fetal levels of expression in hyperplasia or malignancy. It is considered as a pan-carcinoma marker. During metastasis, the ability of malignant cells to form multicellular aggregates via homotypic or heterotypic aggregation and their adhesion to the endothelium are critical. The tumor-associated carbohydrate Thomsen-Friedenreich antigen (Gal-GalNAc) is involved in tumor cell adhesion and tissue invasion. It also causes an immune response, and overexpression of the antigen causes cancer cells to be more sensitive to natural killer cell lysis. The Thomsen-Friedenreich antigen is suppressed in normal healthy cells and represents one of the few chemically well-defined antigens associated with tumor malignancy. The presence of the Thomsen-Friedenreich antigen on the surface of cancer cells may result from a divergence from the normal pathway for O-linked glycosylation in these cells, most likely caused by inappropriate localization of the enzymes involved in synthesis of the disaccharide.

Supplier: ProSci Inc.

Recognises a protein of 57 kDa, identified as p57Kip2. It shows no cross-reaction with p27Kip1. p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. Anti-p57 has been used as an aide in identification of complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts and stromal cells) from partial hydatidiform mole (PHM) in which both cytotrophoblasts and stromal cells stain. The histological differentiation of complete mole, partial mole, and hydropic spontaneous abortion is problematic. Most complete hydatidiform moles are diploid, whereas most partial moles are triploid. Ploidy studies will identify partial moles, but will not differentiate complete moles from non-molar gestations. Complete moles carry a high risk of persistent disease and choriocarcinoma, while partial moles have a very low risk. In normal placenta, many cytotrophoblast nuclei and stromal cells are labeled with this antibody. Similar findings apply to PHM and hydropic abortus tissues. Intervillous trophoblastic islands (IVTIs) demonstrate nuclear labeling in all three entities and serve as an internal control.

Supplier: HUBER

Quick release / nipple M24x1,5 Temperature range: -75C...230C Connection: M24X1,5 AG Connection point: Temperature control unit, application max. pressure at 20C: 25 bar Nominal width: 12 mm Note: When using ethanol as thermofluid: When ethanol is 1 * 1 items

Supplier: Amarell

Thermometer similar to BS 1365, SB65C/total, 55+65:0,1C, solid stem, white backed, capillary tube specially coated inside, with no n-wetting blue special liquid, 235mm long, total immersion, durable pigment, null

Supplier: COMARK

RF313+ WiFi Datalogger High Accuracy + 12-months FREE Cloud Application, large LCD, Integral Temperature and Humidity. Including wall bracket and micro USB Lead. -20C to +60C (-4F to +140F), 0 T0 100% rh. 1 * 1 items

Supplier: MEMMERT

The ICO series of CO₂ incubators has seamlessly welded, corrosion-resistant stainless steel chambers with rounded edges and no further installations, ensuring easy and thorough cleaning. Models have TwinDISPLAY with a USB port for uploading programs, reading out logs or protecting appliances via the user ID function, and an Ethernet interface as well as a data logger with a 10 year storage capacity. All parameters can be set directly in the ControlCOCKPIT or the AtmoCONTROL software, which uses drag and drop symbols to input values. Battery-buffered ControlCOCKPIT (optional): Operating display, logging and CO₂ control are fully functional even during a power failure.

Supplier: ProSci Inc.

This antibody recognises human blood group A (monofucosyl and difucosyl A antigens with chain types 1, 2, 3, 4, 5, 6) and Forssmann antigen. It is also reactive with the immuno-dominant A trisaccharide. Blood group antigen expression in human colon cancer was studied by means of two monoclonal antibodies of broad anti-A (HE-14) and anti-type 3 and type 4 chain-based A and H (HE-10) specificity. These antigens were proved to re-appear in tumors of the distal colon, the HE-10 antibody reacting more frequently (9 out of 12 samples) than HE-14 (5 out of 12 samples) and frequently with supra-nuclear staining of the cytoplasm probably in those places of the Golgi apparatus where carbohydrate antigens are synthesised. This staining pattern is characteristic of HE-10 in normal colonic mucosa as well. With HE-14, staining was often absent in less differentiated tumors, while HE-10 did react in such tumors. In some cases, these two antibodies gave different staining patterns in parallel sections from the same tissue sample, primarily at the cellular level. Three out of 12 cases showed blood group antigen expression in the mucosa of the distal colon adjacent to the tumor only when HE-10 mAb was used.

Supplier: COMARK

RF311+ WiFI DataLogger High Accuracy version + 12-months FREE Cloud Application, large LCD, Internal Temperature Sensor only. Including wall bracket and micro USB Lead. -20C to +60C (-4F to +140F) 1 * 1 items

Supplier: ProSci Inc.

This antibody recognises an intra-cytoplasmic marker antigen which shows a very high degree of specificity for plasma cells. This marker protein is present in normal as well as neoplastic plasma cells. Plasma cells, which are large lymphocytes derived from an antigen-specific B cell, secrete antibodies and are responsible for humoral immunity. Plasma cells differentiate from B cells upon stimulation by CD4+ lymphocytes. The B cell acts as an antigen-presenting cell (APC), consuming an offending pathogen, which is taken up by the B cell by phagocytosis and broken down within proteosomes. Plasma cells contain basophilic cytoplasm; their nucleus contains heterochromatin organized in a characteristic cartwheel arrangement. This marker antibody superbly recognises normal and neoplastic plasma cells in routine formalin/paraffin tissue sections. It is of potential value in identifying myeloma or plasmacytoma in bone marrow or other tissues. It also helps differentiate lympho-plasmacytoid lymphoma from lymphocytic and follicular lymphoma. Note that this plasma cell marker antibody is not suitable for staining frozen tissues.

Supplier: ProSci Inc.

This antibody recognises a protein of 33-37 kDa, identified as CD20 (Workshop V; Code CD20.12). The antibody recognises the extracellular domain of the protein. The epitope is similar to or identical to that recognized by other CD20 antibodies including Leu-16 and B1. This antibody can be used for immunophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood, Bcell localization in tissues and B lymphocyte purification by immunosorbent methods. CD20 is a non-Ig differentiation antigen of Bcells and its expression is restricted to normal and neoplastic Bcells, being absent from all other leukocytes and tissues. It is expressed by pre Bcells and persists during all stages of Bcell maturation but is lost upon terminal differentiation into plasma cells. Protein passes through the membrane 4 times with both ends in cytoplasm and exposes one short and one longer loop to the external environment. CD20 is not glycosylated in resting Bcells and its cytoplasmic domains are differentially phosphorylated upon activation. It acts as a calcium channel involved in Bcell activation and cell cycle progression.

Supplier: ProSci Inc.

Recognises a protein of 57 kDa, identified as p57Kip2. It shows no cross-reaction with p27Kip1. p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. Anti-p57 has been used as an aide in identification of complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts and stromal cells) from partial hydatidiform mole (PHM) in which both cytotrophoblasts and stromal cells stain. The histological differentiation of complete mole, partial mole, and hydropic spontaneous abortion is problematic. Most complete hydatidiform moles are diploid, whereas most partial moles are triploid. Ploidy studies will identify partial moles, but will not differentiate complete moles from non-molar gestations. Complete moles carry a high risk of persistent disease and choriocarcinoma, while partial moles have a very low risk. In normal placenta, many cytotrophoblast nuclei and stromal cells are labeled with this antibody. Similar findings apply to PHM and hydropic abortus tissues. Intervillous trophoblastic islands (IVTIs) demonstrate nuclear labeling in all three entities and serve as an internal control.

Supplier: OMEGA BIO-TEK

Isolate DNA from plant or fungal samples using spin columns.

Supplier: GETINGE LIFE SCIENCES

DETERGENT PUMP M500 ASSY 230V 60Hz APT 1 * 1 items

Supplier: VACUUBRAND

Package Fine vacuum control CVC3000 + VSP3000, KF DN 25 1 * 1 items

Supplier: ProSci Inc.

CD45, also referred to as CD45R and PTPRC (Protein tyrosine phosphatase receptor type C), has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Along with other members of the PTP family, it regulates a number of cellular processes including cell differentiation, growth and mitotic cycle, and is an essential regulator of B- and T-cell antigen receptor-mediated activation.

Multiple isoforms of CD45 are distributed throughout the immune system and arise due to alternative splicing of exons located in the N-terminus. CD45RA contains the A exon and is a naive T-cell marker which may help prevent autoimmune disease. CD45RB contains B and stains most leukemias and lymphomas. CD45RC contains C and stains thymocytes, monocytes and dendritic cells. CD45RO doesn't contain A, B or C and is a marker of activated T-cells that can be used to classify and diagnose and classify lymphomas. This antibody will bind to all CD45 isoforms. The variation in these isoforms is localized to the extracellular domain, with the intracellular domain being conserved. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

Supplier: ProSci Inc.

Reacts with a protein of 57 kDa, identified as the L1 protein of human papilloma virus type 16 (HPV-16). Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on the basement membrane to provide initial virion attachment to target cells. Basement membrane is exposed only after epithelium trauma. Additionally, the alpha6 integrin complexed with either beta1 or beta4 integrin has been proposed to act as a coreceptor recognized by L1. Once attached, integrin complexed with beta4 integrin has been proposed to act as a coreceptor recognized by L1. Once attached, the virion enters the host cell via clathrin-mediated endocytosis and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2. [UniProt]

The antibody reacts very strongly with formalin-fixed, paraffin-embedded tissues containing HPV-16 or -33; very weak reactions were occasionally observed with biopsy specimens or smears containing HPV-6 or HPV-11. It cross-reacts with HPV37.

Supplier: NICKEL ELECTRO

Digital and analogue linear shaking water baths with a stainless steel tank housed in a durable outer case. The corrosion resistant reciprocating trolley readily accepts perforated clip trays for holding flasks and test tube racks. The trolley is easily removed for cleaning purposes and a stainless steel recessed top accommodates flasks, clip trays etc prior to and after immersion. The 28 litre baths include a drain tap for convenient emptying. Digital shakers have splash proof controls featuring an advanced PID temperature controller with a LED display, allowing observation of set and actual temperature simultaneously to 0,1 °C resolution. They also feature a highly accurate PT 100 sensor with the added advantage that it is immersed in the water for accurate temperature measurement. An over-temperature alarm operates on digital baths at 4 °C above set point which switches of the heaters to protect the users work until a safe working temperature is achieved. Analogue model has an electronic temperature controller and an electronic speed control for shaking. The heater and safety device are concealed beneath the tank allowing for easy cleaning.

Supplier: Azbil Telstar Technologies

The ergonomically designed BiOptima Class II microbiological safety cabinets ensure optimum efficiency and high-level energy savings. BiOptima provides operator protection with the inflow air barrier, product protection thanks to HEPA-filtered laminar downflow in the working area and environmental protection through the exhaust HEPA filter. BiOptima Cyto is available in 120 or 180 cm (4 or 6’) widths as standard.

Supplier: OMEGA BIO-TEK

Isolate DNA from plant or fungal sample with organic solvents using spin columns.

Supplier: witeg Labortechnik

Homogenizer HS-30E, 200-5000 rpm, analog internal controller, as a set Set includes : Unit : HS-30E Clamp : CL200 for stirrer and homogeniser Plate stand with rod : ST110 plate 20x35 cm, rod dia. 16x h800 mm NOTE: No tissue grinder included 1 * 1 items

Supplier: GRAVIS

SIROP BLANC 60ML + CAPS. INV. PP TRISEAL 1 * 5.588 items

Supplier: MACHEREY-NAGEL

Filter paper folded MN 715 1/4 60.0cm diameter, pack of 100. 1 * 100 items

Supplier: Testo

Testo 871s thermal imager together with our experienced professionals to enable you to work quickly and easily with professional thermal imaging technology. Generates error-free and objectively comparable infrared images using its handy functions. The IFOV warner, testo ɛ-Assist and testo ScaleAssist mean can avoid measurement errors and not only effortlessly achieve optimum setting of emissivity (ɛ) and reflected temperature (RTC) for building thermography, but also of colour scale. This combines high infrared resolution with professional measuring performance and easy handling. Its high-quality pixel detector, an integrated digital camera and, last but not least, the innovative functions are the features that impress. The testo Thermography App enables the testo 871s to offer smart thermography to meet professional requirements in industry and trade. The case supplied with the thermal imager means it can be conveniently transported.

Supplier: Roth Carl

APARATUS CFS 1 * 1 items

Supplier: SIGMUND LINDNER

Typ ZY Premium 1 * 20 kg