Supplier: ProSci Inc.

PECAM-1, or platelet endothelial cell adhesion molecule-1, also called CD31, is made up of six extracellular immunoglobulin-like domains, a single transmembrane domain, and a cytoplasmic domain containing serine and tyrosine residues that when phosphorylated, activate the molecules signaling function. It is expressed on platelets, monocytes, neutrophils, bone marrow macrophage and dendritic cells precursors, and at the intracellular junction of endothelial cells. PECAM-1, on the endothelial lining of blood vessels, helps maintain the vascular barrier. In response to inflammatory mediators, the endothelial pull away from each other allowing fluid, inflammatory cells and proteins into the extravascular space. The inflammatory response fades as adhesion of neighboring cells increase. PECAM-1 also plays an important role in angiogenesis, promoting endothelial cell motility, junctional development and capillary morphogenesis.

Supplier: ProSci Inc.

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.

Supplier: SMEG

SINGLE-PHASE ELECTRIC CONNECTION 1 * 1 items

Supplier: ProSci Inc.

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.

Supplier: ProSci Inc.

Growth hormone (GH), also known as somatotropin (or as human growth hormone [hGH or HGH] in its human form), is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals. It is thus important in human development. It is a type of mitogen which is specific only to certain kinds of cells. Growth hormone is a 191-amino acid, single-chain polypeptide that is synthesised, stored, and secreted by somatotropic cells within the lateral wings of the anterior pituitary gland.

GH is a stress hormone that raises the concentration of glucose and free fatty acids. It also stimulates production of IGF-1.

The major isoform of the human growth hormone is a protein of 191 amino acids and a molecular weight of 22,124 daltons. The structure includes four helices necessary for functional interaction with the GH receptor. It appears that, in structure, GH is evolutionarily homologous to prolactin and chorionic somatomammotropin. [Wiki].

Supplier: ProSci Inc.

Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Supplier: Lovibond Tintometer

A series of spectrophotometric colorimeters for colour grading of optically clear samples. Each version of the PFXi 195 includes a selection of standard colour scales that is used in a specific industry sector. Additional scales can be added, at the time of order or remotely, as optional upgrades, to provide the flexibility to meet individual requirements. Results can also be displayed in terms of spectral data and CIE values. For product types that are incompatible with the standard colour scales, the PFXi 195 software allows the users to build up a customised scale from a series of reference samples, and then to obtain the closest match to the stored reference.

Supplier: MP Biomedicals

p nitrophenol is the substrate of choice for use with alkaline phosphatase in ELISA procedures. This substrate produces a soluble end product that is yellow in color and can be read spectrophotometrically at 405 nm. The pNPP reaction may be stopped with 3 M NaOH and read at 405 nm.

Supplier: ProSci Inc.

Tryptophan hydroxylase (TPH) catalyzes the 5-hydroxylation of tryptophan, which is the first step in the biosynthesis of indoleamines (serotonin and melatonin) (Martinez et al., 2001). In mammals, serotonin biosynthesis occurs predominantly in neurons which originate in the Raphe nuclei of the brain, and melatonin synthesis takes place within the pineal gland. Although TPH catalyzes the same reaction within the Raphe nuclei and the pineal gland, TPH activity is rate-limiting for serotonin but not melatonin biosynthesis. Serotonin functions mainly as a neurotransmitter, whereas melatonin is the principal hormone secreted by the pineal gland. The activity of TPH is enhanced by phosphorylation by cAMP-dependent protein kinase (PKA) and Ca2+/calmodulin kinase II (CaM K II) (Jiang et al., 2000; Johansen et al., 1996). CaM K II phosphorylates Ser19 which lies within the regulatory domain of TPH2 (McKinney et

Supplier: ProSci Inc.

It is well known that the control of gene expression involves activation of protein kinase cascades that regulate transcription factors within the nucleus (Karin and Hunter, 1995). The cyclic AMP response element binding protein (CREB) is one of the best characterized stimulus-induced transcription factors (Montminy, 1997). This transcription factor is a component of intracellular signaling events that regulate a wide range of biological functions, from spermatogenesis to circadian rhythms and memory (Shaywitz and Greenberg, 1999; Silva et al., 1998). A variety of protein kinases including protein kinase A (PKA), mitogenactivated protein kinases (MAPKs), and Ca2+/calmodulin-dependent protein kinases (CaMKs) phosphorylate CREB at serine 133 (Ser133), and phosphorylation of Ser133 are required for CREB-mediated transcription (Johannessen et al., 2004; Kornhauser et al., 2002).

Supplier: Portwest

The DX4 slim fit work bib is expertly designed for exceptional comfort, flexibility, and protection. Made using dynamic 4× stretch fabrics which assure greater ease of movement.

Supplier: VWR Collection

This user friendly portable instrument with robust IP 67 rated housing provides high resolution and accuracy for precise measurements of pH, mV, conductivity and oxygen in field applications (can only be used to measure any two of these at the same time). Complete with waterproof USB output for connection to a computer. GLP compliant.

Supplier: VWR Collection

VWR® has expanded the VWR® carboy features and benefits by offering the Versatile Cap, Versatile Barb and state-of-the-art Spigot technology. These three components complement a wide array of applications supported by the VWR® Carboy. The leakproof cap insert with replaceable gasket enable users to quickly change the top connector of each carboy to match the application needs. Versatile Cap is stackable and is offered in both 83 mm (compatible with most industry carboys) and a 120 mm extra wide-mouth version that fits exclusively on VWR® 20 L and 40 L extra wide mouth carboys. To see homogenisation of solutions, closed adapter inserts with a clear window are available. Quick connect options are also a part of the many capabilities of this Versatile Cap technology. This includes quick-connect port combinations of two, three, and four. For bottom tubulation, Versatile Barb is used to replace the spigot and support flexibility in drainage, connection to a pump or automated equipment, or connection to a filling bell. Sanitary fitting connector is also available in order to enable the carboy to be used as a supply reservoir to a larger system.

Supplier: WATERS

COLUMN ORB SAX 80Å 10µM 4.6M 1 * 1 items

Supplier: FRITSCH

Test Sieve 400/65 mm, mesh = 0.16 mm ISO 3310-1 1 * 1 items

Supplier: BIGNEAT

HPL Flat Base, 800mm wide 1 * 1 items

Supplier: VWR Chemicals

VWR® dehydrated culture media that has been granulated offers both convenience and safety benefits. The correct dissolution of culture media is critical to achieving the best performance. Granulated culture media saves time in the preparation of ready to use culture media. In addition, granulation reduces dust generation, so handling the product is more pleasant and safer for the user, making it a much cleaner and safer working environment.

Supplier: GERHARDT

PVC-TUBE 10X1MM L=400MM 1 * 1 items

Supplier: Abnova

Recombinant protein, gprc5d (np_061124.1) recombinant protein without tag. 1 * 2 µG

Supplier: Socorex Isba

SOC NOZZLE EXTENSION 10L 1 * 1 items

Supplier: MORGAN ADVANCED MATERIALS HALD

PLATE FIRM 200X10X200MM 1 * 1 items

Supplier: Ahlstrom-Munksjö

IN.PAPER PH 1-14 ROLLE 1 * 1 items

Supplier: MP Biomedicals

PLURONIC F-68® POLYOL 1 * 100 mL

Supplier: SCHUELKE MAYR

MIKROZID AF WIPES JUMBO BOX (220PCS) 1 * 1 kg

Supplier: IKA

PLATE FOR VMS-C10 1 * 1 items

Supplier: Abnova

Recombinant protein, npy1r (aah71720.1) recombinant protein without tag. 1 * 2 µG

Supplier: GERING

HYDROMETER BAUME 0-5 0,1 15C 1 * 1 items

Supplier: Abnova

Recombinant protein, cd7 (np_006128.1) recombinant protein without tag. 1 * 2 µG

Supplier: Abnova

Recombinant protein, cd97 (np_001775.2) recombinant protein without tag. 1 * 2 µG

Supplier: ZWIEBEL

SINGLE WEIGHT MADE OF CAST-IRON 10KG 1 * 1 items