116 Results for: "(1-Phenylethylidene)malononitrile"

Used as a ligand in transition-metal complex catalyst chemistry. Oxime acts as an antioxidant, radical scavenger which find applications in textile, plastic, paint, detergent, and rubber industry.

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Tyrphostin 1 95%

Supplier: Apollo Scientific

Tyrphostin 1 95%

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2-(Methoxymethylidene)propanedinitrile

Supplier: Apollo Scientific

2-(Methoxymethylidene)propanedinitrile

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1,1-Dicyano-4-phenylbutadiene 98%

Supplier: Apollo Scientific

1,1-Dicyano-4-phenylbutadiene 98%

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Ethoxymethylenemalononitrile 95%

Supplier: Apollo Scientific

Ethoxymethylenemalononitrile 95%

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Ethoxymethylenemalononitrile 98%

Supplier: Thermo Fisher Scientific

Ethoxymethylenemalononitrile 98%

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4-(Dicyanomethylene)-2,6-dimethyl-4H-pyran 95%

Supplier: Apollo Scientific

4-(Dicyanomethylene)-2,6-dimethyl-4H-pyran 95%

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Tyrphostin AG-126

Supplier: Apollo Scientific

MAPK/ERK Signalling Pathway

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FCCP ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

MPTP inhibitor

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Tyrphostin 1 ≥99%

Supplier: ENZO LIFE SCIENCES

An inactive tyrphostin, which may be used as a negative control.

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Tyrphostin A23 ≥99% (by TLC)

Supplier: ENZO LIFE SCIENCES

A potent inhibitor of EGF receptor kinase activity (IC50=35 µM).

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Ethoxymethylenemalononitrile ≥97%

Supplier: Thermo Fisher Scientific

Ethoxymethylenemalononitrile ≥97%

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4-(Dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran 96+%

Supplier: Thermo Fisher Scientific

Appearance: Red to red-brown Powder or crystals

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4-Hydroxybenzylidenemalononitrile ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

The tyrphostins are well known tyrosine kinase inhibitors. However, tyrphostin 8 has been shown to inhibit calcineurin (IC50=21 µM) while displaying weak inhibition of EGFR tyrosine kinase (IC50=560 µM).

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Tyrphostin A9 ≥99% (by HPLC)

Supplier: ENZO LIFE SCIENCES

Tyrphostin 9 is a selective inhibitor of the PDGF receptor tyrosine kinase (IC50=1.2 µM). It is also a potent (10 nM) uncoupler of oxidative phosphorylation.

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Tyrphostin AG-126 ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES

AG-126 prevents lipopolysaccharide-induced lethal toxicity (septic shock) in mice. Administered at 1.5 mg/mouse, it reduced LPS-induced lethal toxicity from 95% to 10%. AG-126 greatly reduces LPS-induced tyrosine phosphorylation of p42MAPK in murine peritoneal macrophages at 50 µM. EGFR, Her-2/neu receptor or PDGF-R are not inhibited at 100 µM. Inhibits tyrosine kinase-dependent B cell receptor signaling.

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(Aza((4-fluorophenyl)amino)methylene)methane-1,1-dicarbonitrile

Supplier: Apollo Scientific

(Aza((4-fluorophenyl)amino)methylene)methane-1,1-dicarbonitrile

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Tyrphostin AG 1024 ≥98% (by HPLC and UV method)

Supplier: ENZO LIFE SCIENCES

Specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor kinases. Induces apoptosis by downregulation of the expression of phospho-Akt1 and Bcl-2. Also increases Bax, p53 and p21 expression.