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SIEVE ASTM.E11-95 8X2INCH 63.0MM S.S./S. 1 * 1 items

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SIEVE ASTM.E11-95 8X2INCH 50.0MM S.S./S. 1 * 1 items

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SIEVE ASTM.E11-95 8X2INCH 90.0MM S.S./S. 1 * 1 items

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SIEVE ASTM.E11-95 8X2INCH 032µM S.S./S.S 1 * 1 items

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SIEVE ASTM.E11-95 8X2INCH 045µM S.S./S.S 1 * 1 items

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SIEVE ASTM.E11-95 8X2INCH 106µM S.S./S.S 1 * 1 items

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SIEVE ASTM.E11-95 8X2INCH 1.18MM S.S./S. 1 * 1 items

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SIEVE ASTM.E11-95 8X2INCH 500µM S.S./S.S 1 * 1 items

Supplier: Bioss

Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. In vein endothelial cells, inhibits PI3K/Akt signaling activity and thus induces apoptosis in response to the oxidant peroxynitrite (in vitro). Regulates UV radiation-induced DNA damage response mediated by CDKN1A.

Supplier: Bioss

Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. In vein endothelial cells, inhibits PI3K/Akt signaling activity and thus induces apoptosis in response to the oxidant peroxynitrite (in vitro). Regulates UV radiation-induced DNA damage response mediated by CDKN1A.

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SIEVE ASTM.E11-95 8X2INCH 2.36MM S.S./S. 1 * 1 items

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Universal clamping device comfort for 10 test sieves 1 * 1 items

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SIEVE ASTM.E11-95 8X2INCH 063µM S.S./S.S 1 * 1 items

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SIEVE ASTM.E11-95 8X2INCH 075µM S.S./S.S 1 * 1 items

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SIEVE ASTM.E11-95 8X2INCH 125MM S.S./S.S 1 * 1 items

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SIEVE ASTM.E11-95 8X2INCH 106MM S.S./S.S 1 * 1 items

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SIEVE ASTM.E11-95 8X2INCH 12.5MM S.S./S. 1 * 1 items

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SIEVE ASTM.E11-95 8X2INCH 13.2MM S.S./S. 1 * 1 items

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SIEVE ASTM.E11-95 8X2INCH 180µM S.S./S.S 1 * 1 items

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SIEVE ASTM.E11-95 8X2INCH 710µM S.S./S.S 1 * 1 items

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SIEVE ASTM.E11-95 8X2INCH 1.40MM S.S./S. 1 * 1 items

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SIEVE ASTM.E11-95 8X2INCH 22.4MM S.S./S. 1 * 1 items

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SIEVE ASTM.E11-95 8X2INCH 2.80MM S.S./S. 1 * 1 items

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SIEVE ASTM.E11-95 8X2INCH 6.30MM S.S./S. 1 * 1 items

Supplier: VWR Collection

This 'two in one' lab water system produces ultrapure (Type I) and RO (Type III) water from tap water. Quality of ultrapure water meets or exceeds ASTM, CLSI, CAP, and ISO Type I water standards.

Supplier: Ahlstrom-Munksjö

General purpose Filter Paper, N3 m/N, 110 mm, discs 1 * 100 items

Supplier: JULABO GmbH

QUAD DISTRIBUTING ADAPTERS G 1 1/4 F. WITH BARBED FITTINGS FOR TUBING 1 INNER DIAMETER 1 * 2 items

Supplier: LGC Standards PROMOCHEM

PIROXICAM IMP. E (EP): ETHYL (3-OXO-2,3- 1 * 100 mg

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Cooling plate mps/cx incl. accs 115v/60 hz 1 * 1 items

Supplier: Cytiva

Sera-Xtracta virus/pathogen kit for high-throughput total nucleic acid (DNA/RNA) isolation from bacteria and viruses including adenovirus (type 14), influenza A (H3N2) and COVID-19.