21854 Results for: "(\u00B1)-Tetrahydrofurfuryl+bromide&pageNo=11&view=easy"

Supplier: Bioss

Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf130 gene product has been provisionally designated C1orf130 pending further characterization.

Supplier: Bioss

Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf130 gene product has been provisionally designated C1orf130 pending further characterization.

Supplier: Bioss

Comprising more than ten subunits, the anaphase-promoting complex (APC) acts in a cell-cycle dependent manner to promote the separation of sister chromatids during the transition between metaphase and anaphase in mitosis. APC, or cyclosome, accomplishes this progression through the ubiquitination of mitotic cyclins and other regulatory proteins that are targeted for destruction during cell division. APC is phosphorylated, and thus activated, by protein kinases Cdk1/cyclin B and polo-like kinase (Plk). APC is under tight control by a number of regulatory factors, including CDC20, CDH1 and MAD2. Specifically, CDC20 and CDH1 directly bind to APC and activates APC’s cyclin-ubiquitination activity. In contrast, MAD2 inhibits APC by forming a ternary complex with CDC20 and APC; thus preventing APC activation. APC11 is a RING-H2 finger protein that allows for the synthesis of multiubiquitin chains in the presence of Ubiquitin carrier protein 4 (Ubc4) and ubiquitin conjugating enzyme (E2). In addition, a heterodimeric complex of either Ubc4 or UbcH10 with APC11 and APC2 catalyzes the ubiquitination of human securin and cyclin B1.

Supplier: Bioss

E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.

Supplier: Thermo Scientific

TSX™ core series is engineered for reliability and designed for everyday use. When choosing a ULT freezer, protecting your valuable samples is the top priority.  The Thermo Scientific™ TSX™ core series ULT freezers are designed with this in mind, offering reliable sample protection even in the busiest laboratory environments.

Supplier: asecos

Safe active and passive storage of lithium-ion batteries.

Supplier: Bioss

IGSF11 is also known as BTIGSF (brain and testis-specific immunoglobulin superfamily protein) or VSIG3 (V-set and immunoglobulin domain-containing protein 3) and is a 431 amino acid protein that is expressed as three isoforms. IGSF11 is highly expressed in testis and ovary and is also expressed in brain, kidney and skeletal muscle, localized to the cellular membrane as a single-pass membrane protein. IGSF11 is an immunoglobulin with V-type and C2-type domains that function in molecular recognition. When IGSF11 is in the trans position, it plays an important role in cell-cell adhesion via both homophilic and heterophilic interactions with other molecules. These cell–cell interactions are also thought to be important for neuronal cell interactions, such as neuron–neuron or neuron–glia interactions, which are important for the development and function of the central nervous system. In addition, IGSF11 might also be involved interactions between Sertoli cells and spermatocytes, which are important associations during spermatogenesis. The IGSF11 gene is commonly upregulated in gastric cancer and IGSF11 is highly expressed in many types of human tumors, indicating that it may be useful as a target for immunotherapy.

Supplier: Bioss

IGSF11 is also known as BTIGSF (brain and testis-specific immunoglobulin superfamily protein) or VSIG3 (V-set and immunoglobulin domain-containing protein 3) and is a 431 amino acid protein that is expressed as three isoforms. IGSF11 is highly expressed in testis and ovary and is also expressed in brain, kidney and skeletal muscle, localized to the cellular membrane as a single-pass membrane protein. IGSF11 is an immunoglobulin with V-type and C2-type domains that function in molecular recognition. When IGSF11 is in the trans position, it plays an important role in cell-cell adhesion via both homophilic and heterophilic interactions with other molecules. These cell–cell interactions are also thought to be important for neuronal cell interactions, such as neuron–neuron or neuron–glia interactions, which are important for the development and function of the central nervous system. In addition, IGSF11 might also be involved interactions between Sertoli cells and spermatocytes, which are important associations during spermatogenesis. The IGSF11 gene is commonly upregulated in gastric cancer and IGSF11 is highly expressed in many types of human tumors, indicating that it may be useful as a target for immunotherapy.

Supplier: Bioss

Comprising more than ten subunits, the anaphase-promoting complex (APC) acts in a cell-cycle dependent manner to promote the separation of sister chromatids during the transition between metaphase and anaphase in mitosis. APC, or cyclosome, accomplishes this progression through the ubiquitination of mitotic cyclins and other regulatory proteins that are targeted for destruction during cell division. APC is phosphorylated, and thus activated, by protein kinases Cdk1/cyclin B and polo-like kinase (Plk). APC is under tight control by a number of regulatory factors, including CDC20, CDH1 and MAD2. Specifically, CDC20 and CDH1 directly bind to APC and activates APC’s cyclin-ubiquitination activity. In contrast, MAD2 inhibits APC by forming a ternary complex with CDC20 and APC; thus preventing APC activation. APC11 is a RING-H2 finger protein that allows for the synthesis of multiubiquitin chains in the presence of Ubiquitin carrier protein 4 (Ubc4) and ubiquitin conjugating enzyme (E2). In addition, a heterodimeric complex of either Ubc4 or UbcH10 with APC11 and APC2 catalyzes the ubiquitination of human securin and cyclin B1.

Supplier: HAMILTON BONADUZ

The 700 series syringe is the original hand-fitted Hamilton syringe. This series of syringes is ideal for dispensing volumes from 0,5 to 500 µl. The stainless steel plunger is manufactured to fit the glass barrel with a tolerance smaller than 100 millionths of an inch, resulting in unsurpassed syringe life. Each syringe is manufactured to achieve the highest level of accuracy and precision possible.

Supplier: HUBER

Heating circulation bath thermostats with either polycarbonate or stainless steel baths, which are simple to use and are suitable for a variety of applications such as: Sample temperature control, analysis, materials testing or checking food. The units offer high temperature stability and are fitted with over-temperature and low level protection suitable for Safety Class III/FL (DIN 12876) for use with flammable fluids. A powerful pressure/suction pump ensures optimum circulation and temperature homogenity in the bath and also allows temperature control of externally attached applications using a pump adapter (accessory).

Supplier: EPPENDORF

Eppendorf Deepwell plates 96-well, 2000 µl offer efficient sample handling with features like OptiTrack® matrix for rapid identification and g-Safe® technology for stability during centrifugation. SafeCode variants provide secure three-level coding, including error correction for reliable identification, ensuring flexibility and accuracy in experimental workflows.

Supplier: Priorclave

Compact 40 benchtop and Compact 60 floor standing or benchtop autoclaves for the low volume user, with flexible operation usually only available in larger autoclave units. This flexibility is delivered by the TACTROL™ microprocessor control system, specially developed for laboratory autoclaves, with programming ranging from simple cycles to fully featured multi-program operation with logged records. All Priorclaves come complete with Biomaster antimicrobial coating, helping improved laboratory hygiene; it is effective against all bacteria and fungi including MRSA and therefore helps minimise the risk of cross contamination.

Supplier: Portwest

Breathable jacket made of 300D Oxford weave which features contemporary design 4-in-1 versatile jacket that offers four combinations: light weight outer, outer with body warmer combined, wear-alone body warmer and reverse colour body warmer.

Supplier: EPPENDORF

The robust Reference® 2 is the successor to the Reference® pipette and features a new design, reduced weight and unique one-button operation.

Supplier: Sartorius

Vivaspin® 20 centrifugal concentrators offer increased volume flexibility and performance to the Vivaspin® potfolio. Vivaspin® 20 handles 5 to 20 ml in swing bucket rotors and 14 ml in fixed angle rotors accepting 50 ml centrifuge tubes. Vivaspin® 20 features twin vertical membranes for unparalleled filtration speed and >100-fold concentration. Volume graduation allows monitoring the concentration process and the modified dead stop pocket simplifies pipetting of the final concentrate.

Supplier: ProSci Inc.

SHP2 Antibody: Src homology-2 domain containing protein (SHP2) is a member of the protein tyrosine phosphatase (PTP) family, a protein family that contains signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. SHP2 contains two tandem Src homology-2 (SH2) domains, which function as phosphotyrosine binding domains either directly or through scaffolding intermediates such as the insulin-receptor substrate 1 (IRS-1). These SH2 domains mediate the interaction of SHP2 with its substrates, allowing SHP2 to dephosphorylate proteins that inhibit signaling kinases such as ERK1 and AKT. SHP2 is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Recent experiments have shown SHP2 plays a significant role in hepatoprotection and liver regeneration.

Supplier: Portwest

The DX4 zip base layer top is lightweight and breathable, which assists with perfect body temperature control. The high stretch, highly durable nylon fabric complements the body mapped design. The full front zip with chin guard has a rubber puller for easy grip.

Supplier: ProSci Inc.

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.

Supplier: Corning

PP, graduated. The DeckWorks™ system is designed to maximise storage space and help reduce the production and waste of plastic materials. Both the hinged racks and reload decks within this system are manufactured with recycled plastic.

Supplier: FRISTADS KANSAS

These overalls consist of different fabric combinations. The fluorescent material is water repellent and manufactured from 80% polyester and 20% cotton. The other parts are made of 65% polyester and 35% cotton with a soft nap on reverse. The reinforcement is made from 100 % polyamide.

Supplier: Boster Bio

Mitogen-activated protein kinase kinase kinase 8 is an enzyme that in humans is encoded by the MAP3K8 gene. This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. Additionally, this protein was found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein.

Supplier: BIOTIX

This new generation of tips form an excellent seal on both single- and multi-channel pipettes guaranteeing total recovery of the sample whilst protecting the technician against the risks of repetitive strain injury. The tips are manufactured with proprietary technologies for increased pipetting accuracy and precision.

Supplier: SIOEN

These lightweight, breathable trousers made of Siopor® FR AST fabric (100% polyester fabric with 100% FR PU coating + AST) are waterproof and windproof and have anti-static features. The fixed cotton lining is flame-retardant. The trousers provide good tear resistance and protection against rough weather conditions.

Supplier: IKA

Laboratory stirrers designed for simple stirring tasks for quantities up to 15 or 25 L (EUROSTAR 20 digital and EUROSTAR 40 digital), or for intensive stirring tasks for quantities up to 20 L (EUROSTAR 20 high speed digital). Units automatically adjust the speed through microprocessor controlled technology within the speed range of 0/30 to 2000 min⁻¹ (or 0/150 to 6000 for the high speed model). Safety circuits ensure automatic cut off in anti-stall or overload conditions. The actual shaft speed and preset speed are constantly monitored and variations are adjusted automatically. This guarantees a constant speed even with changes in sample viscosities.

Supplier: ProSci Inc.

HSD11B1 is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, HSD11B1 can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children.The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.

Supplier: Portwest

Versatile and comfortable protection against all weather conditions. The detachable fur lining and collar, in combination with the zip-out sleeves, prove this is a superbly adaptable garment. Numerous zipped outer and interior pockets afford excellent personal security. Two-way zip for quick and easy access.

Supplier: VWR Collection

Stainless steel circulating baths with choice of Advanced Programmable or Advanced Digital temperature controller. Both are easy to navigate with large, intuitive displays and multiple communication options, including USB-A and B, RS232/485, Ethernet and external temperature probe. The reservoir drain can be accessed by removing the front panel. All models feature user-adjustable, high temperature safety cut-off points, as well as over-temperature protection. The surface is cool to the touch, even when operating at high temperatures.

Supplier: EPPENDORF

Eppendorf Deepwell plates 96-well, 1000 µl offer efficient sample handling with features like OptiTrack® matrix for rapid identification and g-Safe® technology for stability during centrifugation. SafeCode variants provide secure three-level coding, including error correction for reliable identification, ensuring flexibility and accuracy in experimental workflows.

Supplier: RPB SAFETY

The RPB Z-link respirator with FR chin seal, is the world's most comfortable (fully padded) and versatile industry respirator. Providing the highest respiratory protection available (TH3), the Z-Link system also provides hard hat protection, eye and face protection and hearing protection.