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Latrunculin A

1
Catalog # CAYM10010630-50
Supplier:   Cayman Chemical
Latrunculin A
Catalog # CAYM10010630-50
Supplier:  Cayman Chemical
CAS Number:  76343-93-6
Latrunculin A

1

Specifications
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Specifications
CAS Number:  76343-93-6
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Product Details & Documents

Latrunculin A is a bioactive 2-thiazolidinone macrolide derived from sponges that sequesters G-actin and prevents F-actin assembly. It binds monomeric actin with 1:1 stoichiometry and can be used to block actin polymerization both in vitro (Kd = 0,2 μM) and in cells (0,5 μM, 30 min).

Latrunculin A (1-10 μM) causes depolymerization of tumor cell cytoskeleton within ten minutes. Overnight treatment of cells with latrunculin A (10 μM) strongly suppresses actin synthesis. Prolonged cell treatment blocks dexamethasone-induced changes in actin cytoskeleton with no effect on cell viability. Actin disruption is used to study cell functions in vitro (e.g., migration, endocytosis) and in vivo (e.g., tumor cell invasion).

Synonyms:  (4R)-4-[(1R,4S,5E,7Z,11E,15R,17R)-17-hydroxy-4,11-dimethyl-13-oxo-14,18-dioxabicyclo[13.3.1]nonadeca-5,7,11-trien-17-yl]-1,3-thiazolidin-2-one
  • CAS Number:76343-93-6
  • Formula:C₂₂H₃₁NO₅S
  • Molecular Weight:421.552 g/mol
  • Storage Temperature:Freezer
Specifications

Specifications

  • Pk:
    1

Specifications

   
Acetonitrile, anhydrous (max. 0.003% H₂O) ≥99.95%, HiPerSolv CHROMANORM® Reag. USP, Reag. Ph. Eur., ACS, super gradient grade suitable for UPLC/UHPLC instruments

  #: 83639.320

Supplier: VWR Chemicals

Methanol ≥99.8%, HiPerSolv CHROMANORM® Reag. Ph. Eur., gradient grade for HPLC

  #: 20864.320

Supplier: VWR Chemicals

VWR®, Transfer Pipettes, High Performance

  #: 612-1681

Supplier: VWR Collection

Acetone ≥99%, TECHNICAL

  #: 20063.365

Supplier: VWR Chemicals

VWR® Serological Pipette, Standard Line

  #: 612-3700

Supplier: VWR Collection

VWR®, Nitrile Gloves

  #: 112-3101

Supplier: VWR Collection

Acetonitrile ≥99.9%, HiPerSolv CHROMANORM® for LC-MS, suitable for UPLC/UHPLC instruments

  #: 83640.320

Supplier: VWR Chemicals

VWR® Facial Tissues

  #: 115-0600

Supplier: VWR Collection

Nitrile gloves, Kimtech™ Purple Nitrile™

  #: 112-4847

Supplier: Ansell

Acetonitrile ≥99.9%, LiChrosolv® Reag. Ph. Eur., gradient grade for liquid chromatography, Supelco®

  #: 1.00030.2500

Supplier: Merck

pH indicator strips, MQuant®, Supelco®

  #: 1.09535.0001

Supplier: Merck

Sealing film for manual application, Parafilm® M

  #: 291-0057

Supplier: HEATHROW

VWR® NITRILE LIGHT, Nitrile Gloves

  #: 112-2754

Supplier: VWR Collection

Water, HiPerSolv CHROMANORM® for HPLC

  #: 23595.328

Supplier: VWR Chemicals

Sodium hydroxide 0.1 mol/l (0.1 N) in aqueous solution, AVS TITRINORM Reag. Ph. Eur. volumetric solution

  #: 31770.294

Supplier: VWR Chemicals

VWR® AVS TITRINORM Buffer Solutions, 20 °C

  #: 32096.291

Supplier: VWR Chemicals

Water, HiPerSolv CHROMANORM® for LC-MS, suitable for UPLC/UHPLC instruments

  #: 83645.320

Supplier: VWR Chemicals

Buffer solutions, ready to use, referenced at 20 °C, Certipur®, Supelco®

  #: 1.09439.1000

Supplier: Merck

VWR® Nitrile Extra Light, Nitrile Gloves

  #: 112-4195

Supplier: VWR Collection

epT.I.P.S.® Bulk - Pipette Tips

  #: 613-3508

Supplier: EPPENDORF