Human Recombinant IL-10 (CTGrade GMP) (from E. coli)

Supplier: Shenandoah Biotechnology

New Product

Certificates

Supplier: Shenandoah Biotechnology

New Product

About this item

IL-10 is an anti-inflammatory cytokine produced by macrophages and type 2 T helper (Th2) cells.

High quality
Low endotoxin
Lot-to-lot consistency
Animal free
Manufactured following GMP guidelines

Inhibits the production of pro-inflammatory cytokines such as interferon gamma (IFNγ), tumor necrosis factor alpha (TNFα), interleukin 2 (IL-2), interleukin 3 (IL-3), interleukin 4 (IL-4), and granulocyte-macrophage colony-stimulating factor (GM-CSF), made by macrophages and regulatory T cells
Suppresses antigen presentation on antigen presenting cells, and enhances the survival, proliferation, and antibody production of B cells
The biological activity of CTGrade GMP interleukins and growth factors is standardised, where applicable, to WHO International standards, providing cell and gene therapy developers consistent, lot-to-lot biological activity and performance

Host Cell Protein: ≤30 ng/ml
Host Cell DNA: ≤0,01 ng/ml
Sterility testing: No Growth
Mycoplasma: Negative

Caution: For research use or further manufacturing only.

Some Products May Appear Restricted

To ensure a smooth and speedy checkout, please log in to your account. Some items may show as restricted simply because you're not logged in.

If you do not have an account, you can register using our registration webform (https://www.avantorsciences.com/us/en/login/register)

If you're still seeing restrictions after logging in, certain products—like chemicals or medical devices—require additional account verification steps to be able to place an order. Some items may additionally require a specific license or customer documentation; additional documentation will be requested for these items prior to shipment.

Specifications

Conjugation:
Unconjugated
Protein function:
Cytokine
Protein/peptide type:
Recombinant
Source:
E. coli
Species:
Human
Storage conditions:
At or below –20 °C
Endotoxin content:
Endotoxin LAL (EU/µg) ≤0,05
Biological activity:
Bioactivity Assay: Proliferation of MC/9, ED₅₀ ≤5 ng/ml, Bioactivity ≥5,0×10³ IU/µg
Gene ID:
P22301
Reconstitution instructions:
Sterile water at 0,1 - 0,5 mg/ml
Endotoxin-free:
N
Carrier-free:
Y
Protease-free:
N
Animal-free:
Y
Protein synonyms:
B-TCGF|TGIF|CSIF
Protein/peptide name:
CTGrade GMP IL-10
Purity:
≥97%
Molecular weight:
18,8 kDa
Sequence:
MSPGQGTQSE NSCTHFPGNL PNMLRDLRDA FSRVKTFFQM KDQLDNLLLK ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPDIKA HVNSLGENLK TLRLRLRRCH RFLPCENKSK AVEQVKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTMKIR N
Endotoxin level:
Low
Formulation:
10 mM Sodium phosphate, pH 7,5
Nuclease-free:
N
Grade:
GMP
Shipping temperature:
Ambient
Tested applications:
Bioassay