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Specifications
- Antibody type:Primary
- Antigen name:DNA (cytosine-5)-methyltransferase 3-like
- Antigen symbol:DNMT3L
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- ImmunoChemistry:Yes
- Reactivity:Human
- Western blot:Yes
- Epitope:Amino Acid Range = 357-388
- Form:Liquid
- Gene ID:Q9UJW3
- Antigen synonyms:DNMT3L
- Modification:None
- Storage buffer:Supplied in PBS with 0,09% (W/V) sodium azide
- Molecular weight:44 kDa
- Storage temperature:Store at 4 °C for three months and –20 °C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Concentration:2 mg/ml
- Shipping temperature:4 °C
- Immunogen:This Dnmt3L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 357-388 amino acids from the C-terminal region of human Dnmt3L.
- Purification:This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
- Size:400 µl
- Pk:400 µl
Specifications
About this item
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases. This protein is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, this protein does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and it is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternative splicing results in two transcript variants. An additional splice variant has been described but its biological validity has not been determined.
For WB starting dilution is: 1:1000. For IHC-P starting dilution is: 1:50~100.
Type: Primary
Antigen: DNMT3L
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: Rabbit Ig
Reactivity: Human