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Specifications
- Antibody type:Primary
- Antigen name:integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
- Antigen symbol:ITGB2
- Clonality:Monoclonal
- Clone:68-5A5
- Conjugation:Unconjugated
- Flow cytometry:Yes
- Host:Mouse
- ImmunoFluorescence:Yes
- Isotype:IgG2a kappa
- Reactivity:Human
- Western blot:Yes
- Neutralisation:Yes
- Format:Purified Antibody
- Form:Liquid
- Gene ID:P05107
- Antigen synonyms:ITGB2
- Storage buffer:PBS with 0,1 mg/ml BSA and 0,05% sodium azide
- Storage temperature:Aliquot and Store at 2…8 °C. Avoid freez-thaw cycles.
- Concentration:0,2 mg/ml
- Shipping temperature:4 °C
- Immunogen:Stimulated human leukocytes were used as the immunogen for the CD18 antibody.
- Tested applications:Functional
- Purification:Protein G affinity chromatography
- Size:100 µg
- Pk:100 µG
Specifications
About this item
It recognises a transmembrane glycoprotein of 95 kDa, identified as CD18 or integrin -2 (Workshop III). It complexes non-covalently with either L, M, or X integrin (CD11a, b, or c) to form the heterodimers, LFA-1, Mac-1, and p150,95, respectively. LFA-1 is the receptor for three members of the Ig supergene family of proteins, ICAM-1 (CD54), ICAM-2 (CD102), and Mac-1 and p150,95 bind to ICAM-1, fibrinogen, and iC3b. ICAM-3 (CD50). CD18/CD11 heterodimeric molecules are involved with cell/cell and cell/extracellular adhesion in immune and inflammatory responses. This mAb blocks these cellular interactions.
Functional Activity (Order SAF formulation) Flow Cytometry: 0,5-1 µg/million cells in 0,1 ml Immunofluorescence: 0,5 - 1 µg/ml Optimal dilution of the CD18 antibody should be determined by the researcher.
Type: Primary
Antigen: ITGB2
Clonality: Monoclonal
Clone: 68-5A5
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2a, kappa
Reactivity: Human