Specifications
- Pack type:Vial
- Pk:25 µG
- Conjugation:Unconjugated
- Protein/peptide type:Recombinant
- Source:HEK293 cells
- Species:Human
- Storage conditions:Lyophilised protein should be stored at −20 °C or lower for long term storage. Upon reconstitution, working aliquots should be stored at −20 or −70 °C. Avoid repeated freeze-thaw cycles.
- Gene ID:2064
- Protein synonyms:NEU|MLN19|TKR1|ERBB2|CD340|HER2|HER-2/neu|NGL
- Protein/peptide name:Her2
- Purity:>95% as determined by SDS-PAGE. Endotoxin level is less than 1,0 EU per µg by the LAL method.
- Molecular weight:74,5 kDa
- Sequence:Thr 23 - Ile 450
- Formulation:Lyophilised. Tris with glycine, arginine and NaCl, pH 7,5.
- Shipping temperature:RT
- Tested applications:This recombinant protein can be used for western blot
Specifications
About this item
Human Epidermal growth factor Receptor 2 (HER2), also called ERBB2, HER-2, HER-2/neu, NEU, NGL,TKR1 and c-erb B2,and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family.
HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product.
Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer,communication at the neuromuscular junction andregulation of cell growth and differentiation.