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Specifications
- Antibody type:Primary
- Antigen name:HSP 40-4/HDJ2/DNAJA1
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 680
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Mouse
- Western blot:Yes
- Epitope:21-110/397
- Form:Liquid
- Antigen synonyms:OTTHUMP00000021193|HDJ-2|DJ 2|DNAJ2|Heat shock 40 kDa protein 4|heat shock protein DNAJ like 2|HSJ-2|Heat shock protein J2|DnaJ Hsp40 homolog, subfamily A, member 1|HSPF4|DNJA1_HUMAN|DjA1|HDJ2|Neural precursor cell expressed developmentally down regulated 7|DJ2|HSDJ|NEDD7|HSJ2|hDJ 2|DnaJ protein homolog 2|Human DnaJ protein 2|DnaJ homolog subfamily A member 1|Dnaja1
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:45 kDa
- Storage temperature:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human HSP 40-4
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
DnaJ-like proteins interact with HSP 70 molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen Signalling.
Type: Primary
Antigen: HSP 40-4/HDJ2/DNAJA1
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 21-110/397
Host: Rabbit
Isotype: IgG
Reactivity: Mouse