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Specifications
- Antibody type:Primary
- Antigen name:Nck1/NCK alpha
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 350
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Epitope:31-150/377
- Form:Liquid
- Gene ID:4690
- Antigen synonyms:NCK1|NCKalpha|Melanoma Nck protein|Non catalytic region of tyrosine kinase|NCK adaptor protein 2|SH2/SH3 adaptor protein NCK alpha.|NCK 1|Nck adaptor protein 1|NCK tyrosine kinase|Cytoplasmic protein NCK1|MGC12668|SH2/SH3 adaptor protein NCK alpha
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:25 kDa
- Storage temperature:Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human Nck2
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
Nck is a highly conserved, oncogenic protein. It is a common target for the action of different surface receptors, encoding one SH2 and three SH3 domains, the Src homology motifs found in nonreceptor tyrosine kinases, Ras GTPase activating protein, phosphatidylinositol 3 kinase, and phospholipase Cg. Nck is widely expressed in various tissues and in cell lines from human, murine, and rat origins. Nck is phosphorylated on tyrosine, serine, and threonine residues in response to stimulation of EGF and PDGF in A431 and NIH 3T3 cells respectively. Like other SH2 containing proteins, Nck is associated with tyrosine autophosphorylated EGF or PDGF receptors via its SH2 domain. Overexpression of Nck leads to transformation of NIH 3T3 cells.
Type: Primary
Antigen: Nck1/NCK alpha
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 350
Public Immunogen Range: 31-150/377
Host: Rabbit
Isotype: IgG
Reactivity: