Some Products May Appear Restricted
To ensure a smooth and speedy checkout, please log in to your account. Some items may show as restricted simply because you're not logged in.
If you do not have an account, you can register using our registration webform (https://www.avantorsciences.com/us/en/login/register)
If you're still seeing restrictions after logging in, certain products—like chemicals or medical devices—require additional account verification steps to be able to place an order. Some items may additionally require a specific license or customer documentation; additional documentation will be requested for these items prior to shipment.
Specifications
- Antibody type:Primary
- Antigen name:VHL/HRCA1
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 750
- Flow cytometry:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human
- Epitope:101-213/213
- Form:Liquid
- Gene ID:7428
- Antigen synonyms:Von Hippel-Lindau disease tumor suppressor.|von Hippel-Lindau syndrome protein homolog|von Hippel Lindau syndrome|Hippel-Lindau disease tumor suppressor VHL|VHL 1|Protein G7|VHL|VHLH|RCA1|G7 protein|von Hippel-Lindau disease tumor suppressor isoform 2|Elongin binding protein|pVHL|Von Hippel Lindau|VHL1|Von Hippel Lindau disease tumor suppressor|von Hippel-Lindau tumor suppressor isoform 1|von Hippel Lindau tumor suppressor|VHL_HUMAN|HRCA1
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:24 kDa
- Storage temperature:Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human VHL
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Type: Primary
Antigen: VHL/HRCA1
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 101-213/213
Host: Rabbit
Isotype: IgG
Reactivity: Human