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Specifications
- Antibody type:Primary
- Antigen name:MAP1A/MAP1B LC3 A/B
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 750
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Rabbit,Human,Rat,Mouse
- Western blot:Yes
- Epitope:21-121/121
- Form:Liquid
- Gene ID:81631, 84557
- Antigen synonyms:MAP1A/1BLC3|Autophagy related ubiquitin like modier LC3 B|MAP1 light chain 3 like protein 1|MAP LC3 beta|MAP1LC3B|Autophagy related protein LC3 B|Microtubule associated proteins 1A/1B light chain 3A|MAP1BLC3|Autophagy related ubiquitin like modier LC3 A|Microtubule associated protein 1 light chain 3 beta|MAP1ALC3|Microtubule associated proteins 1A/1B light chain 3B.microtubule-associated proteins 1A/1B light chain 3 beta 2|MAP1A/MAP1B LC3 B|Microtubule associated protein 1 light chain 3 alpha|MAP1LC3A|MAP1A/1B light chain 3 B|LC3|MAP1 light chain 3 like protein 2|Microtubule associated proteins 1A/1B light chain 3|MAP1A/MAP1B LC3 A|Autophagy related protein LC3 A|MAP1A/1B light chain 3 A
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:13 kDa
- Storage temperature:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human MAP1A/MAP1B LC3 B
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
A major contributor to cellular homeostasis is the ability of the cell to strike a balance between the formation and degradation/removal of its cellular components. This process of internal cellular turn-over is called autophagy (self-eating), and is facilitated by a pathway of around 16 interacting proteins in the human. LC3, a ubiquitin-like modifier protein, is the human homolog of yeast Apg8 and is involved in the formation of autophagosomal vacuoles, called autophagosomes. LC3 is expressed as 3 splice variants (LC3A, LC3B and LC3C), which exhibit different tissue distributions and are processed into cytosolic and autophagosomal membrane-bound forms, termed LC3-I and LC3-II, respectively. A disruption to the autophagic process is now associated with the progression of several cancers, neurodegenerative disorders and cardiac pathologies, where LC3 is widely employed as a marker for autophagy.
Type: Primary
Antigen: MAP1A/MAP1B LC3 A/B
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 21-121/121
Host: Rabbit
Isotype: IgG
Reactivity: Human; Mouse; Rat; Rabbit