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Specifications
- Antibody type:Primary
- Antigen name:Aurora A+B+C
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 680
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human
- Western blot:Yes
- Epitope:51-150/344
- Form:Liquid
- Gene ID:6790
- Antigen synonyms:IPL1|BTAK|IPL1 Related Kinase|AURKB|Aurora Related Kinase 1|Aurora and Ipl1 like midbody associated protein 1|AurB|STK5|IPL1 Aurora Related Kinase 1|AURA|AURKC|Aurora related kinase 2|MGC34538.
AIK2|STK12|Aurora/IPL1 Like Kinase|Serine threonine protein kinase 13|AIE2|Breast Tumor Amplied Kinase|AURKA_HUMAN|Aurora Family Kinase 1|STK13|ARK1|Aurora A|EC 2.7.11.1|Aurora/IPL1 Related Kinase 1|Aurora 1|IPL-1|Serine/threonine protein kinase 12|BRAK|AIM1|Aurora 2|AURORA2|hARK1|ARK2|Aurora-B|Aurora/Ipl1/Eg2 protein 2|Serine/theronine kinase 12|AURKA|Aurora/IPL1 related kinase 2|Aurora/Ipl1 related kinase 3|AurC|Aurora C|STK1|Aurora kinase B|AYK1|aurora kinase A|IAK|AIK3|AIK - Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:46 kDa
- Storage temperature:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human Aurora A/B/C
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colourectal. Aurora A is viewed as a potential target for anticancer drug treatment.Aurora B is a mitotic protein kinase that phosphorylates histone H3 (probably on Serine 10), behaves as a chromosomal passenger protein, and may regulate several stages of mitosis such as centrosome separation, chromosome segregation and cytokinesis. It localises to the inner centromere region from prophase to anaphase. The Aurora kinases, members of the Ser/Thr protein kinase family, associate with microtubules during chromosome movement and segregation. Aurora kinase C may play a part in organising microtubules in relation to the function of the centrosome/spindle pole during mitosis. This protein is localised to centrosome from anaphase to cytokinesis. Expression is limited to testis in normal cells. Elevated expression levels are seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Aurora-C expression is maximum at M phase.
Type: Primary
Antigen: Aurora A+B+C
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 51-150/344
Host: Rabbit
Isotype: IgG
Reactivity: Human