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Specifications
- Antibody type:Primary
- Antigen name:TWIST1 and TWIST2
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 750
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Western blot:Yes
- Epitope:71-170/202
- Form:Liquid
- Gene ID:7291; 117581
- Antigen synonyms:Twist related bHLH protein Dermo1|Twist homolog 2|Twist 2|TWIST1|Twist2|Dermis expressed protein 1|Class A basic helix-loop-helix protein 38|DERMO1|bHLHa38|bHLHa39|TWST2_HUMAN|Dermis-expressed protein 1|TWIST|H-twist|DERMO 1|Twist-related protein 1|Twist homolog 2 Drosophila|Dermo-1|Twist related protein 2|MGC117334|Twist-related protein 2|Class A basic helix-loop-helix protein 39
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:23 kDa
- Storage temperature:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human TWIST1
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
TWIST1 and TWIST2 are basic helix-loop-helix transcriptional repressors that bind to E boxes in gene promoters, acting as master regulators in a variety of biological processes, including organogenesis, osteogenesis, cancer progression and hematopoietic cell development. Both TWIST1 and TWIST2 are found to act as Homodimers or Heterodimers with another bHLH protein. TWIST1 Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. TWIST1 also represses expression of proinflammatory cytokines such as TNFA and IL1B. TWIST2 inhibits transcriptional activation by MYOD1, MYOG, MEF2A, and MEF2C. Twist2 inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis.
Type: Primary
Antigen: TWIST1 and TWIST2
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 71-170/202
Host: Rabbit
Isotype: IgG
Reactivity: Human; Mouse; Rat