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Specifications
- Antibody type:Primary
- Antigen name:WDFY1 + WDFY2
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 750
- Flow cytometry:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Rat
- Epitope:21-120/410
- Form:Liquid
- Gene ID:57590, 115825
- Antigen synonyms:WDF1|Phosphoinositide binding protein SR1|Phosphoinositide binding protein 1|Zinc finger FYVE domain containing protein 17|WD repeat and FYVE domain containing 1|FENS1|WDFY2|ZFYVE17|FENS-1|Phosphoinositide-binding protein 1|WD40 and FYVE domain containing protein 1|WD repeat and FYVE domain-containing protein 1|WD repeat and FYVE domain-containing protein 2|WDFY1|KIAA1435|ZFYVE22|WD40- and FYVE domain-containing protein 2|FENS 1|Zinc finger FYVE domain-containing protein 17|WDF2|Zinc finger FYVE domain-containing protein 22|Propeller-FYVE protein|WD40- and FYVE domain-containing protein 1|WDFY1_HUMAN
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:46 kDa
- Storage temperature:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human WDFY1
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
WD-repeats are motifs that are found in a variety of proteins and are characterised by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. WDFY1 positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. WDFY1 Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines. WDFY2 acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2. WDFY2 positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1.
Type: Primary
Antigen: WDFY1 + WDFY2
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 21-120/410
Host: Rabbit
Isotype: IgG
Reactivity: Rat