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Specifications
- Antibody type:Primary
- Antigen name:Alpha B Crystallin Ser19
- Clonality:Polyclonal
- Conjugation:FITC (Fluorescein Isothiocyanate)
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Mouse
- Western blot:Yes
- Form:Liquid
- Gene ID:1410
- Antigen synonyms:HSPB5|Heat shock 20 kD like protein|NY REN 27 antigen|alpha crystallin B chain|CRYA2|alpha B crystallin|alpha-crystallin B chain|Renal carcinoma antigen NY REN 27|Heat shock protein beta-5|alphaB crystallin|CRYAB_HUMAN|crystallin alpha B|alphaB-crystallin|Rosenthal fiber component|p-alpha B crystallin Ser19|CTPP2|p-alpha B crystallin S19|CTPP 2|crystallin alpha polypeptide 2|Renal carcinoma antigen NY-REN-27|AACRYA|Heat shock protein beta 5|CRYAB|alpha B crystallin phospho S19|alpha B crystallin phospho Ser19
- Modification:Phosphorylation (Ser19)
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:20 kDa
- Storage temperature:Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic phosphopeptide derived from human alpha B Crystallin around the phosphorylation site of Ser19
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Zince lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30 to 40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy.
Type: Primary
Antigen: alpha B Crystallin Ser19
Clonality: Polyclonal
Clone:
Conjugation: FITC
Public Immunogen Range:
Host: Rabbit
Isotype: IgG
Reactivity: Mouse