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Specifications
- Antigen name:CD80 molecule
- Antigen symbol:CD80
- Clone:16-10A1
- Flow cytometry:Yes
- Host:Armenian hamster
- ImmunoChemistry:Yes
- ImmunoPrecipitation:Yes
- Isotype:IgG
- Reactivity:Mouse
- Gene ID:12519
- Antigen synonyms:TSA1|B71|Ly-53|MIC17|Cluster of Differentiation 80|Cd28l|Ly53
- Storage temperature:Store undiluted at 2-8 °C, protect from light, do not freeze.
- Tested applications:Functional Assay, Immunofluorescence Microscopy
- Pk:100 µG
Specifications
About this item
The 16-10A1 antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.
Type:
Antigen: CD80
Clonality:
Clone: 16-10A1
Conjugation:
Epitope:
Host: Armenian Hamster
Isotype: IgG
Reactivity: