Human recombinant Amphiregulin (from E. coli)

Supplier: Shenandoah Biotechnology

Certificates

Supplier: Shenandoah Biotechnology

About this item

Amphiregulin (AR) is a member of the epidermal growth factor (EGF) family.

Produced from genetically modified E. coli
Monomeric protein, containing 87 amino acids
Promotes ductal outgrowth and mammary branching
Up-regulated at puberty
Functions as a mitogen and prevents hepatocyte apoptosis in liver

AR is an autocrine growth factor and functions to regulate cell proliferation and survival through binding the EGF receptor (EGFR). In a cancer, AR protects against human adenocarcinoma apoptosis, promotes tumor cell growth, and functions as an oncogenic factor in the hippo pathway. AR levels are increased in the brain following stress events, such as inflammation, ischemia, and hypoxia. It also promotes the proliferation of neural stem cells and epithelial cells, including keratinocytes and mammary epithelium.

Delivery: A certificate of analysis (COA) is supplied with each product shipped detailing purity, formulation, biological activity, endotoxin levels, reconstitution instructions and recommended storage conditions.

Caution: This product is for research use only and is not for use in humans.

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Specifications

Conjugation:
Unconjugated
Protein function:
Cytokine
Protein/peptide type:
Recombinant
Source:
E. coli
Species:
Human
Storage conditions:
–20 °C
Endotoxin content:
Endotoxin LAL (EU/µg) ≤0,1
Biological activity:
Bioactivity assay: 3T3 Cell Proliferation , ED50 ≤20 ng/ml, Bioactivity ≥5,0×10⁴ units/mg
Gene ID:
P15514
Reconstitution instructions:
Sterile water at 0.1 mg/ml
Endotoxin-free:
N
Carrier-free:
Y
Protease-free:
N
Animal-free:
N
Protein synonyms:
AR|Colorectum cell-derived growth factor|CRDGF|AREG
Protein/peptide name:
Amphiregulin
Purity:
≥95%
Molecular weight:
10,1 kDa
Sequence:
SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER CGEKSMK
Endotoxin level:
Low
Formulation:
10 mM sodium phosphate, pH 7,5
Nuclease-free:
N
Grade:
RUO
Shipping temperature:
RT
Tested applications:
Bioassay