Human recombinant CD40-ligand (from E. coli)

CD40 ligand (CD40L) or CD154 is a membrane glycoprotein and differentiation antigen that is expressed on the surface of T cells, monocytes, basophils, eosinophils, platelets, dendritic cells, and endothelial cells.

Produced from genetically modified E. coli
Monomeric protein, containing 149 amino acids
Activates CD40 receptor on antigen-presenting cells

These proteins are stimulating B cell proliferation, immunoglobulin class switching, and antibody secretion. In peripheral blood monocytes, these are helps to induces cytokine production and tumoricidal activity in peripheral blood monocytes. These CD40L are also act as a co-stimulator for the activation of T cell proliferation and inflammatory protein production.

: A certificate of analysis (COA) is supplied with each product shipped detailing purity, formulation, biological activity, endotoxin levels, reconstitution instructions and recommended storage conditions.

: This product is for research use only and is not for use in humans.

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Conjugation:
Unconjugated
Protein function:
Cytokine
Protein/peptide type:
Recombinant
Source:
E. coli
Species:
Human
Storage conditions:
–20 °C
Endotoxin content:
Endotoxin LAL (EU/µg) ≤0,1
Biological activity:
Bioactivity assay: Activity of HEK-blue™ CD40L cells, ED50 ≤50 ng/ml, Bioactivity ≥2,0×10⁴ units/mg
Gene ID:
P29965
Reconstitution instructions:
Sterile water at 0.1 mg/ml
Endotoxin-free:
N
Carrier-free:
Y
Protease-free:
N
Animal-free:
N
Protein synonyms:
TRAP|gp39|CD154|T-BAM|TNFSF5
Protein/peptide name:
CD40-Ligand
Purity:
≥95%
Molecular weight:
16,3 kDa
Sequence:
MQKGDQNPQI AAHVISEASS KTTSVLQWAE KGYYTMSNNL VTLENGKQLT VKRQGLYYIY AQVTFCSNRE ASSQAPFIAS LWLKSPGRFE RILLRAANTH SSAKPCGQQS IHLGGVFELQ PGASVFVNVT DPSQVSHGTG FTSFGLLKL
Endotoxin level:
Low
Formulation:
10 mM sodium phosphate, pH 7,5
Nuclease-free:
N
Grade:
RUO
Shipping temperature:
RT
Tested applications:
Bioassay