Some Products May Appear Restricted
To ensure a smooth and speedy checkout, please log in to your account. Some items may show as restricted simply because you're not logged in.
If you do not have an account, you can register using our registration webform (https://www.avantorsciences.com/us/en/login/register)
If you're still seeing restrictions after logging in, certain products—like chemicals or medical devices—require additional account verification steps to be able to place an order. Some items may additionally require a specific license or customer documentation; additional documentation will be requested for these items prior to shipment.
- Antibody type:Primary
- Antigen name:Osteopontin
- Antigen symbol:OPN
- Clonality:Monoclonal
- ELISA:Yes
- Host:Mouse
- ImmunoChemistry:Yes
- Isotype:IgG2a
- Reactivity:Human
- Western blot:Yes
- Seq:02
- Form:Liquid. In PBS containing 0,1% sodium azide.
- Antigen synonyms:early T-lymphocyte activation 1|bone sialoprotein I|osteopontin|SPP-1|nephropontin|secreted phosphoprotein 1 (osteopontin|bone sialoprotein 1|secreted phosphoprotein-1 (osteopontin|bone sialoprotein)|urinary stone protein|uropontin|SPP1/CALPHA1 fusion|osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein|early T-lymphocyte activation 1)
- Purification:Protein G affinity purified
- Pk:100 µG
Osteopontin (OPN) is an acidic extracellular matrix cell adhesion protein that is relatively abundant not only in bone matrix, plasma, urine, and milk, but is also found in malignant and atherogenic tissues. Phosphorylation, glycosylation and calcium modifications allow intact and fragmented Osteopontin to direct a variety of diverse responses including tissue remodeling, inflammation and cell survival. Plasma Osteopontin has been shown to provide prognostic information in breast, prostate, colon, and lung cancers as well as metastatic carcinomas. The notable presence of Osteopontin in a variety of tumors is strongly correlated to pathological stage, suggesting its critical role in tumor invasiveness, progression and metastasis. In addition, Osteopontin inhibits inducible nitric oxide synthase activity, thereby protecting tumor cells from NO-mediated macrophage cytotoxic attack. Osteopontin is found in atherosclerotic plaques and may drive a number of diabetic vascular pathologies.
Type: Primary
Antigen: OPN
Clonality: Monoclonal
Clone: 53
Conjugation:
Epitope:
Host: Mouse
Isotype: IgG2a
Reactivity: Human